有機合成研究部

研究業績

Catalytic asymmetric synthesis of CF3-substituted tertiary propargylic alcohols via direct aldol reaction of α-N3 amide.
H. Noda, F. Amemiya, K. Weidner, N. Kumagai, and M. Shibasaki
Chem. Sci. 2017, in press
Uique physicochemical and catalytic properties dictated by the B3NO2 ring system.
H. Noda, M. Furutachi, Y. Asada, M. Shibasaki and N. Kumagai
Nat. Chem. 2017, doi: 10.1038/nchem.2708
Asymmetric flow catalysis: mix-and-go solid-phase Nd/Na catalyst for expeditious enantioselective access to a key intermediate of AZD7594.
A. Nonoyama, N. Kumagai and M. Shibasaki
Tetrahedron 2017, 73, 1517-1521
Reversible stereoselective folding/unfolding fueled by the interplay of photoisomerism and hydrogen bonding.
C. R. Opie, N. Kumagai and M. Shibasaki
Angew. Chem. Int. Ed. 2017, in press
Direct catalytic asymmetric aldol reaction of α-alkylamides.
Z. Liu, T. Takeuchi, R. Pluta, F. Arteaga, N. Kumagai and M. Shibasaki
Org. Lett. 2017, 19, 710-713
Catalytic asymmetric synthesis of 2,3,3,3,-tetrafluoro-2-methyl-1-arylpropan-1-amines as useful building blocks for SAR-studies.
L. Brewitz, N. Kumagai and M. Shibasaki.
J. Fluor. Chem. 2017, 194, 1-7.
Strategic immobilization of molecular catalysts onto carbon nanotubes via noncovalent interaction for catalytic organic transformations.
N. Kumagai and M. Shibasaki.
Isr. J. Chem. 2016, in press
Enantioselective synthesis of α,α-disubstituted α-amino acids via direct catalytic asymmetric addition of acetonitrile to α-iminoesters.
S. Lin, N. Kumagai and M. Shibasaki.
Org. Biomol. Chem. 2016. 14, 9725-9730.
Pyramidalization/twisting of the amide functionality via remote steric congestion triggered by metal coordination.
S. Adachi, N. Kumagai and M. Shibasaki.
Chem. Sci. 2017, 8, 85-90.
Catalytic asymmetric synthesis of the C1-C15 segment of spirastrellolide A.
Y. Sahara, J. Cui, M. Furutachi, J. Chen, T. Watanabe and M. Shibasaki.
Synthesis. 2017, 49, 69-75.
Nucleophilic and electrophilic activation of non-heteroaromatic amides in atom economical asymmetric catalysis.
N. Kumagai and M. Shibasaki.
Chem. Eur. J. 2016, 22, 15192-15200.
A career in catalysis: Masakatsu Shibasaki
N. Kumagai, M. Kanai and H. Sasai
ACS Catal. 2016, 6, 4699-4709.
Catalytic asymmetric synthesis of CPZEN-45.
T. Takeuchi, H. Abe, T. Watanabe and M. Shibasaki.
Tetrahedron Lett. 2016, 57, 2901-2904.
Direct catalytic asymmetric mannich-type reaction of alkylamides.
F. Arteaga, Z. Liu, L. Brewitz, J. Chen, B. Sun, N. Kumagai and M. Shibasaki.
Org. Lett. 2016, 18, 2391-2394.
Synthesis of androprostamine A and resormycin.
H. Abe, Y. Yamazaki, C. Sakashita, I. Momose, T. Watanabe and M. Shibasaki.
Chem. Pharm. Bull. 2016, 64, 982-987.
キラリティーを制御して炭素をつなげる -天然物の触媒的不斉全合成
柴﨑正勝、渡辺 匠
化学 2016, 71, 23-26.
Preparation of Nd/Na heterogeneous catalyst from bench-stable and inexpensive Nd salt for an anti-selective catalytic asymmetric nitroaldol reaction.
A. Nonoyama, K. Hashimoto, A. Saito, N. Kumagai and M. Shibasaki.
Tetrahedron Lett. 2016,57,1815-1819.
Electrophilic activation of α,β-unsaturated amides; catalytic asymmetric vinylogous conjugate addition of unsaturated γ-butyrolactones
M. Zhang, N. Kumagai and M. Shibasaki.
Chem. Eur. J. 2016, 22, 5525-5529.
Direct catalytic asymmetric mannich-type reaction of α,β-unsaturated γ-butyrolactam to ketimines.
S. Lin, N. Kumagai and M. Shibasaki.
Chem. Eur. J. 2016, 22, 3296-3299.
Catalytic asymmetric synthesis of key intermediate for scytophycin C
J. Cui, T. Watanabe and M. Shibasaki.
Tetrahedron Lett. 2016, 57, 446-448.
Coccoquinones A and B, new anthraquinone derivatives produced by Staphylotrichum coccosporum PF1460
D. Tatsuda, M. Amemiya, R. Sawa, K. Sumiyoshi, T. Watanabe, I. Momose, M. Kawada, A. Nomoto and M. Shibasaki.
J Antibiot. 2016, 69, 176-178.
Direct catalytic asymmetric mannich-type reaction of α-and β-fluorinated amides.
L. Brewitz, F. Arteaga, L. Yin, K. Alagiri, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2015, 137, 15929-15939.
Direct catalytic asymmetric mannich-type reaction of α-N3 amide.
Z. Sun, K. Widener, N. Kumagai and M. Shibasaki
Chem. Eur. J. 2015, 21, 17574-17577.
Stereoselective total synthesis of KAE609 via directcatalytic asymmetric alkynylation to ketimine.
H. Takada, N. Kumagai and M. Shibasaki.
Org. Lett. 2015, 17, 4762-4765
Synthesis and determination of absolute configuration of lentztrehalose A
M. Zhang, S. Wada, F. Amemiya, T. Watanabe and M. Shibasaki
Chem. Pharm. Bull. 2015, 63, 961-966.
医薬品の効率的不斉合成を志向した協奏機能型不斉触媒の開発
熊谷直哉、柴崎正勝
化学工業 2015, 66, 31-41
Managing the retro-pathway in direct catalytic asymmetric aldol reactions of thioamides.
Y. Bao, N. Kumagai and M. Shibasaki.
Chem. Sci. 2015, 6, 6124-6132
Direct catalytic asymmetric conjugate addition of saturated and unsaturated thioamides.
N. Majumdar, A. Saito, L. Yin, N. Kumagai and M. Shibasaki.
Org. Lett. 2015, 17, 3362-3365
Synthesis and structure-activity relationship study of NBRI16716B, an antitumor natural product.
H. Abe, C. Sakashita, M. Kawada, A. Nomoto, T. Watanabe and M. Shibasaki.
Chem. Pharm. Bull. 2015, 63, 463-468
Synthesis of caprazamycin B
H. Abe, P. Gopinath, G. Ravi, L. Wang, T. Watanabe and M. Shibasaki.
Tetrahedron Lett. 2015, 78, 3782-3785
Direct catalytic asymmetric mannich-type reaction of benzylisocyanide: stereoselective synthesis of 1,2-diarylethylenediamines.
K. Tamura, N. Kumagai and M. Shibasaki.
Eur J Org Chem. 2015, 3026-3031
Direct catalytic asymmetric aldol reaction of α-N3 amide.
K. Weidner, Z. Sun, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2015,54,6236-6240
Quinofuracins A-E, produced by the fungus staphylotrichum boninense PF1444, show p53-dependent growth suppression.
D. Tatsuda, I. Momose, T. Someno, R. Sawa, Y. Kubota, M. Iijima, T. Kunisada, T. Watanabe, M. Shibasaki and A. Nomoto.
J Nat Prod. 2015,78,188-195
Catalytic asymmetric Mannich-type reaction of N-alkylidene α-aminoacetonitrile to ketimines.
S. Lin, Y. Kawato, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2015, 54, 5183-5186
A carbon nanotube confinement strategy to implement homogeneous asymmetric catalysis in the solid phase.
K. Hashimoto, N. Kumagai and M. Shibasaki.
Chem. Eur. J. 2015, 21,4262-4266.
Catalytic generation of α-CF3 enolate: direct catalytic asymmetric mannich-type reaction of α-CF3 amide.
L. Yin , L. Brewitz, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2014, 136, 17958-17961.
Recent advances in catalytic asymmetric C-C bond-forming reactions to ketimines promoted by metal-based catalysts.
N. Kumagai and M. Shibasaki.
Bull. Chem. Soc. Jpn. 2015, 88, 503-517
Antitumor effects of tyropeptin-boronic acid derivatives: new proteasome inhibitors.
I. Momose, H. Abe, T. Watanabe, S. Ohba, K. Yamazaki, S. Dan, T. Yamori, T. Masuda and
A. Nomoto
Cancer Sci. 2014, 105, 1609-1615.
Chromatography-free synthesis of Corey's intermediate for tamiflu.
M. Furutachi, N. Kumagai, T. Watanabe and M. Shibasaki.
Tetrahedron 2014,  70, 9113-9117.
Iterative direct aldol strategy for polypropionates: enantioselective total synthesis of (-)-membrenone A and B.
K. Alagiri, N. Kumagai and M. Shibasaki.
Org. Lett. 2014, 16, 5301-5303.
Design and synthesis of a bis(hydroxyphenyl)diamide bearing a pendant thiazolium unit; application to the catalytic asymmetric intramolecular Stetter reaction.
Y. Bao, N. Kumagai and M. Shibasaki.
Tetrahedron: Asymmetry. 2014, 25, 1401-1408.
Direct catalytic addition of alkylnitriles to aldehydes by transition Metal/NHC complexes.
---selected as a cover picture---
D. Sureshkumar, V. Ganesh,  N. Kumagai and M. Shibasaki.
Chem-Eur.J.  2014, 20, 15723-15726.
Self-assembled asymmetric catalyst engaged in a continuous-flow platform: an anti-selective catalytic asymmetric nitroaldol reaction.
K. Hashimoto, N. Kumagai and M. Shibasaki.
Org. Lett.  2014,  16,  3496-3499.
Regiodivergent kinetic resolution of terminal and internal rac-aziridines with malonates under dinuclear Schiff base catalysis.
Y. Xu, K. Kaneko, M. Kanai, M. Shibasaki and S. Matsunaga.
J. Am. Chem. Soc.  136,  9190-9194.
Catalytic asymmetric total synthesis of (+)-caprazol.
P. Gopinath, L. Wang, H. Abe, G. Ravi, T. Masuda, T. Watanabe and M. Shibasaki.
Org. Lett.  2014,  16,  3364-3367.
A designed amide as an aldol donor in the direct catalytic asymmetric aldol reaction.
K. Weidner, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2014,  53,  6150-6154.
Concise enantioselective synthesis of δ,δ-disubstituted δ-valerolactones.
A. Saito, N. Kumagai and M. Shibasaki.
Tetrahedron Lett.  2014,  55,  3167-3171.
An enantioselective synthesis of the key intermediate for triazole antifungal agents;  application to the aatalytic asymmetric synthesis of efinaconazole (Jublia®).
K. Tamura, N. Kumagai  and M. Shibasaki.
J. Org. Chem.  2014,  79,  3272-3278.
Direct catalytic asymmetric vinylogous conjugate addition of unsaturated butyrolactones to α,β-unsaturated thioamides.
L. Yin, H. Takada, S. Lin, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed.  2014,  53,  5327-5331.
硫黄含有物質を基質とするCooperative  Asymmetric  Catalysis
(2012年度有機合成化学協会 高砂香料国際賞「野依賞」受賞記念寄稿)
柴﨑正勝
The TAKASAGO Times  2013,  172,  26-31.
Recent advances in cooperative bimetallic asymmetric catalysis: dinuclear Schiff base complexes.
S. Matsunaga and M. Shibasaki.
Chem. Commun.  2014,  50,  1044-1057.
Direct aldol strategy in enantioselective total synthesis of thuggacin B.
A. Matsuzawa, C. R. Opie, N. Kumagai and M. Shibasaki.
Chem. Eur. J.  2014,  20,  67-71.
A modified preparation procedure for carbon  nanotube-confined
Nd/Na heterobimetallic catalyst for anti-selective catalytic asymmetric nitroaldol reactions.
D. Sureshkumar, K. Hashimoto, N. Kumagai and M. Shibasaki.
J. Org. Chem.  2013,  78,  11494-11500.
Direct catalytic asymmetric addition of acetonitrile to N-thiophosphinoylimines.
Y. Kawato, N. Kumagai and M. Shibasaki.
Chem. Commun.  2013,  49,  11227-11229.
An enantioselective synthesis of voriconazole.
K. Tamura, M. Furutachi, N. Kumagai and M. Shibasaki.
J. Org. Chem.  2013,  78,  11396-11403.
Identification of octenal-related dA and dC adducts formed by reactions with a hemin-ω-6-fat peroxidation model system.
K. Kawai, Y. Kawasaki, Y. Kubota, T. Kimura, R. Sawa, T. Matsuda and H. Kasai.
Chem. Res. Toxicol.  2013,  26,  1554-1560.
医薬品合成の革新的な不斉触媒反応
─リレンザの純化学合成と再利用可能な触媒の開発
熊谷直哉、柴﨑正勝
化学  2013,  68,  12-17.
Catalytic asymmetric hydrophosphonylation of ketimines.
L. Yin, Y. Bao, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc.  2013,  135, 10338-10341.
Synthesis of intervenolin, an antitumor natural quinolone with unusual substituents.
H. Abe, M. Kawada, H. Inoue, S. Ohba, A. Nomoto, T. Watanabe and M. Shibasaki.
Org. Lett.  2013,  15,  2124-2127.
Structure-activity relationship study of intervenolin derivatives:
synthesis, antitumor and anti-Helicobacter Pylori activities.
H. Abe, M. Kawada, H. Inoue, S. Ohba, T. Masuda, C. Hayashi, M. Igarashi,
A. Nomoto, T. Watanabe and M. Shibasaki.
Tetrahedron  2013,  69,  7608-7617.
Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2.
M. Kawada, H. Inoue, S. Ohba, M. Hatano, M. Amemiya, C. Hayashi, I. Usami, H. Abe, T. Watanabe, N. Kinoshita, M. Igarashi, T. Masuda, D. Ikeda and A. Nomoto.
J. Antibiot.  2013,  66,  543-548.
Direct catalytic asymmetric Mannich-type reaction of α-sulfanyl lactones.
S. Takechi, N. Kumagai and M. Shibasaki.
Org. Lett.  2013,  15,  2632-2635.
Direct catalytic asymmetric vinylogous Mannich-type reaction of
γ-butenolides with ketimines.
L. Yin, H. Takada, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed.  2013,  52, 7310-7313.
Self-assembling neodymium/sodium heterobimetallic asymmetric catalyst confined in
carbon nanotube network.
T. Ogawa, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed.  2013,  52,  6196-6201.
In situ manipulation of catalyst performance via photocontrolled
aggregation/dissociation state of the catalyst.
A. Nojiri, N. Kumagai and M. Shibasaki.
Chem. Commun.  2013,  49,  4628-4630.
Two approaches toward the formal total synthesis of oseltamivir
phosphate (Tamiflu): catalytic enantioselective three-component
reaction strategy and L-glutamic acid strategy.
K. Alagiri, M. Furutachi, K. Yamatsugu, N. Kumagai, T. Watanabe and M. Shibasaki.
J. Org. Chem.  2013,  78,  4019-4026.
Streamlined catalytic asymmetric synthesis of atorvastatin.
---selected as very important paper (VIP)---
Y. Kawato, S. Chaudhary, N. Kumagai and M. Shibasaki.
Chem. Eur. J.  2013,  19,  3802-3806.
Direct catalytic asymmetric alkynylation of ketoimines.
L. Yin, Y. Otsuka, H. Takada, S. Mouri, R. Yazaki, N. Kumagai and M. Shibasaki
Org. Lett.  2013,  15,  698-701.
Multimetallic Schiff base complexes as cooperative asymmetric catalysts.
S. Matsunaga and M. Shibasaki.
Synthesis  2013,  45,  421-437.
Amycolamicin: a novel broad-spectrum antibiotic inhibiting bacterial topoisomerase.
R. Sawa, Y. Takahashi, H. Hashizume, K. Sasaki, Y. Ishizaki, M.Umekita, M. Hatano,
H. Abe, T. Watanabe, N. Kinoshita, Y. Homma, C. Hayashi, K. Inoue, S. Ohba,
T. Masuda,  M. Arakawa, Y. Kobayashi, M. Hamada, M. Igarashi, H. Adachi,
Y. Nishimura and Y. Akamatsu.
Chem. Eur. J.  2012,  18,  15772-15781.
Direct catalytic asymmetric addition of allylic cyanides to aldehydes
for expeditious access to enantioenriched unsaturated
delta-valerolactones.
Y. Otsuka, H. Takada, S. Yasuda, N. Kumagai and M. Shibasaki.
Chem. Asian J.  2013,  8,  354-358.
原子効率と触媒的不斉合成
柴﨑正勝
有機合成化学会誌 2012,  70,  1073-1075.
Studies on catalytic enantioselective total synthesis of caprazamycin B:
construction of the western zone.
P. Gopinath, T. Watanabe and M. Shibasaki.
J. Org. Chem.  2012,  77, 9260-9267.
Asymmetric catalysis with bis(hydroxyphenyl)diamides/rare earth metal complexes.
N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed.  2013, 52, 223-234.
Synthesis and assignment of the absolute configuration of an indenotryptoline bisindole alkaloid, BE-54017.
T. Kimura, S. Kanagaki, Y. Matsui, M. Imoto, T. Watanabe and M. Shibasaki.
Org. Lett.  2012,  14, 4418-4421.
Direct asymmetric α-allylation of ketones with allylic alcohols via Pd/enamine cooperative function.
S. Yasuda, N. Kumagai and M. Shibasaki.
Heterocycles  2012, 86(1), 747-757.
Catalytic chemical transformations with conformationally dynamic catalytic systems.
N. Kumagai and M. Shibasaki.
Catal. Sci. Technol.  2013,  3,  41-57.
Isolation and characterization of signamycine B, an antibiotic that targets the dimerization domain of histidine kinase WalK.
T. Watanabe, M. Igarashi, T. Okajima, E. Ishii, H. Kino, M. Hatano, R.Sawa,
M. Umekita, T. Kimura, S. Okamoto,Y. Eguchi, Y. Akamatsu and R. Utsumi.
Antimicrob. Agents Chemother.  2012,  56,  3657-3663.
Catalytic asymmetric conjugate addition of thiols to α,β-unsaturated thioamides: expeditious access to enantioenriched 1,5-benzothiazepines.
T. Ogawa, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed.  2012,  51,  8551-8554.
anti-Selective direct catalytic asymmetric aldol reaction of thiolactams.
D. Sureshkumar, Y. Kawato, M. Iwata, N. Kumagai and M. Shibasaki.
Org. Lett.  2012,  14,  3108-3111.
Catalytic asymmetric synthesis of spirooxindoles via Mannich-type reaction of isothiocyanato oxindoles.
S. Kato, T. Yoshino, M. Shibasaki, M. Kanai and S. Matsunaga.
Angew. Chem. Int. Ed.  2012,  51,  7007-7010.
Catalytic asymmetric total synthesis of chimonanthine, folicanthine, and calycanthine through double Michael reaction of bisoxindole.
H. Mitsunuma, M. Shibasaki, M. Kanai and S. Matsunaga.
Angew. Chem. Int. Ed.  2012,  51,  5217-5221.
Concise enantioselective synthesis of duloxetine via direct catalytic asymmetric aldol reaction of thioamide.         
Y. Suzuki, M. Iwata, R. Yazaki, N. Kumagai and M. Shibasaki.
J. Org. Chem.  2012,  77,  4496-4450.    
Cooperative asymmetric catalysis using thioamides toward truly practical organic syntheses.
N. Kumagai and M. Shibasaki.
Isr. J. Chem.  2012,  57,  604-612.
Catalytic enantioselective desymmetrization of meso-glutaric anhydrides using a stable Ni2-Schiff base catalyst.
P. Gopinath, T. Watanabe and M. Shibasaki.
Org. Lett.  2012,  14,  1358-1361. 
Catalytic asymmetric amination of oxindoles under dinuclear Ni2-Schiff base catalysis.
S. Mouri, Z. H. Chen, S. Matsunaga and M. Shibasaki.
Heterocycles  2012,  84,  879-892. 
Direct catalytic asymmetric aldol reaction of α-sulfanyl lactones: efficient synthesis of SPT inhibitors.
S. Takechi, S. Yasuda, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed.  2012,  51,  4218-4222. 
Asymmetric synthesis of dihydropyranones from ynones by sequential copper(I)-catalyzed direct aldol and silver(I)-catalyzed oxy-Michael reactions.
S. L. Shi, M. Kanai and M. Shibasaki.
Angew. Chem. Int. Ed.  2012,  51,  3932-3935.
Inhibitors of human 2,3-oxidosqualene cyclase (OSC) discovered by virtual screening.
T. Watanabe, I. Kurata, Y. Umezawa, Y. Takahashi and Y. Akamatsu.
Bioorg. Med. Chem. Lett.  2012,  22,  231-234.
Reversible heterochiral aggregation/dissociation of bis(2-hydroxyphenyl)diamides driven by UV/Vis irradiation.
A. Nojiri, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed.  2012,  51,  2137-2141.
Catalytic asymmetric anti-selective nitroaldol reaction en route to zanamivir.
---selected as Hot Paper---
T. Nitabaru, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed.  2012,  51,  1644-1647.
Intermediate as catalyst: catalytic asymmetric conjugate addition of nitroalkanes to
α,β-unsaturated thioamides.
T. Ogawa, S. Mouri, R. Yazaki, N. Kumagai and M. Shibasaki.
Org. Lett.  2012,  14,  110-113.
A simplified catalytic system for direct catalytic asymmetric aldol reaction of thioamides; application to an enantioselective synthesis of atorvastatin.
Y. Kawato, M. Iwata, R. Yazaki, N. Kumagai and M. Shibasaki.
Tetrahedron  2011,  67,  6539-6546.
Asymmetric synthesis of isothiazoles through Cu catalysis: direct catalytic asymmetric conjugate addition of allyl cyanide to α,β-unsaturated thioamides.
Y. Yanagida, R. Yazaki, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed.  2011,  50,  7910-7914.
La/Ag heterobimetallic cooperative catalysis: a catalytic asymmetric Conia-ene reaction.
A. Matsuzawa, T. Mashiko, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed.  2011,  50,  7616-7619.
Recent advances in direct catalytic asymmetric transformations under proton-transfer conditions.
N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed.  2011,  50,  4760-4772.
Stereodivergent direct catalytic asymmetric Mannich-type reactions of α-isothiocyanato ester with ketimines.
G. Lu, T. Yoshino, H. Morimoto, S. Matsunaga and M. Shibasaki.
Angew. Chem. Int. Ed.  2011,  50,  4382-4385.
Recent development in synthetic strategies for oseltamivir phosphate.
M. Shibasaki, M. Kanai and K. Yamatsugu.
Isr. J. Chem.  2011,  51,  316-328.
Direct catalytic asymmetric intramolecular conjugate addition of thioamide to α,β-unsaturated esters.
Y. Suzuki, R. Yazaki, N. Kumagai and M. Shibasaki.
Chem. Eur. J.  2011,  17,  11998-12001.
Catalytic asymmetric hydroxylation of α-alkoxycarbonyl amides with a Pr(OiPr)3/amide-based ligand catalyst.
S. Takechi, N. Kumagai and M. Shibasaki.
Tetrahedron Lett.  2011,  52,  2140-2143.
Catalytic asymmetric ring-opening of meso-aziridines with malonates under heterodinuclear rare earth metal Schiff base catalysis.
Y. J. Xu, L. Q. Lin, M. Kanai, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc.  2011,  133,  5791-5793.
Direct catalytic enantio- and diastereoselective aldol reaction of thioamides.
M. Iwata, R. Yazaki, I. H. Chen, D. Sureshkumar, N. Kumagai and M. Shibasaki. 
J. Am. Chem. Soc.  2011,  133,  5554-5560.
Cooperative activation of alkyne and thioamide functionalities; direct catalytic asymmetric conjugate addition of terminal alkynes to α,β-unsaturated thioamides.
R. Yazaki, N. Kumagai and M. Shibasaki.
Chem. Asian J.  2011,  6,  1778-1790.
Catalytic asymmetric amination of N-nonsubstituted α-alkoxycarbonyl amides: concise enantioselective synthesis of mycestericin F and G.
F. Berhal, S. Takechi, N. Kumagai and M. Shibasaki.
Chem. Eur. J.  2011,  17,  1915-1921.
Development of atom-economical catalytic asymmetric reactions under proton transfer conditions: construction of tetrasubstituted stereogenic centers and their application to therapeutics.
N. Kumagai.
Chem. Pharm. Bull.  2011,  59,  1-22. 
Enantioselective synthesis of a GPR40 agonist AMG 837 via catalytic asymmetric conjugate addition of terminal alkyne to α,β-unsaturated thioamide.
R. Yazaki, N. Kumagai and M. Shibasaki.
Org. Lett.  2011,  13,  952-955. 
A heterobimetallic Ni/La-salan complex for catalytic asymmetric decarboxylative
1,4-addition of malonic acid half-thioester.
M. Furutachi, S. Mouri, S. Matsunaga and M. Shibasaki.
Chem. Asian J.  2010,  5,  2351-2354.
The synthesis of paleic acid, an antimicrobial agent effective against Mannheimia and
Pasteurella, and its structurally related derivatives.
T. Watanabe, I. Kurata, C. Hayashi, M. Igarashi, R. Sawa, Y. Takahashi and
Y. Akamatsu.
Bioorg. Med. Chem. Lett.  2010,  20,  5843-5846.
Copper(I)-secondary diamine complex-catalyzed enantioselective conjugate boration of
linear β,β-disubstituted enones.
I. H. Chen, M. Kanai and M. Shibasaki.
Org. Lett.  2010,  12,  4098-4101.
Catalytic asymmetric aza-Morita-Baylis-Hillman reaction of methyl acrylate: role of a
bifunctional La(OiPr)3/linked-BINOL complex.
T. Yukawa, B. Seelig, Y. Xu, H. Morimoto, S. Matsunaga, A. Berkessel and M. Shibasaki.
J. Am. Chem. Soc.  2010,  132,  11988-11992.
Direct catalytic asymmetric conjugate addition of terminal alkynes to α,β-unsaturated
thioamides.
R. Yazaki, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc.  2010,  132,  10275-10277.
Identification of modular chiral bisphosphines effective for Cu(I)-catalyzed asymmetric
allylation and propargylation of ketones.
S. L. Shi, L. W. Xu, K. Oisaki, M. Kanai and M. Shibasaki.
J. Am. Chem. Soc.  2010,  132,  6638-6639.
Solvent-dependent self-discrimination of bis(2-hydroxyphenyl)diamides.
A. Matsuzawa, A. Nojiri, N. Kumagai and M. Shibasaki.
Chemistry  2010,  16,  5036-5042.
Direct catalytic asymmetric addition of allyl cyanide to ketones via soft Lewis acid/hard
Brønsted base/hard Lewis base catalysis.
R. Yazaki, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc.  2010,  132,  5522-5531.
Catalytic asymmetric nitro-Mannich reactions with a Yb/K heterobimetallic catalyst.
T. Nitabaru, N. Kumagai and M. Shibasaki.
Molecules  2010,  15,  1280-1290.
Heterobimetallic transition metal/rare earth metal bifunctional catalysis: a Cu/Sm/Schiff base complex for syn-selective catalytic asymmetric nitro-Mannich reaction.
S. Handa, V. Gnanadesikan, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc.  2010,  132,  4925-4934.
Catalytic asymmetric conjugate addition of α-cyanoketones for the construction of a
quaternary stereogenic center.
Y. Kawato, N. Takahashi, N. Kumagai and M. Shibasaki.
Org. Lett.  2010,  12,  1484-1487.
Direct catalytic asymmetric vinylogous Mannich-type and Michael reactions of an
α,β-unsaturated γ-butyrolactam under dinuclear nickel catalysis.
N. E. Shepherd, H. Tanabe, Y. Xu, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc.  2010,  132,  3666-3667.
Catalytic asymmetric 1,4-additions of β-keto esters to nitroalkenes promoted by a
bifunctional homobimetallic Co2-Schiff base complex.
M. Furutachi, Z. Chen, S. Matsunaga and M. Shibasaki.
Molecules  2010,  15,  532-544.
Catalytic asymmetric total synthesis of ent-hyperforin.
Y. Shimizu, S. L. Shi, H. Usuda, M. Kanai and M. Shibasaki.
Angew. Chem. Int. Ed.  2010,  49,  1103-1106.
Catalytic asymmetric synthesis of 3-aminooxindoles: enantiofacial selectivity switch in
bimetallic vs monometallic Schiff base catalysis.
S. Mouri, Z. Chen, H. Mitsunuma, M. Furutachi, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc.  2010,  132,  1255-1257.
Direct catalytic asymmetric aldol reaction of thioamides: a concise asymmetric synthesis
of (R)-fluoxetine.
M. Iwata, R. Yazaki, M. Kumagai and M. Shibasaki.
Tetrahedron: Asymmetry.  2010,  21,  1688-1694.
syn-Selective catalytic asymmetric 1,4-addition of α-ketoanilides to nitroalkenes under
dinuclear nickel catalysis.  
Y. Xu, S. Matsunaga and M. Shibasaki. 
Org. Lett.  2010,  12,  3246-3249.
The first catalytic asymmetric total synthesis of ent-hyperforin.      
Y. Shimizu, S. Shi, H. Usuda, M. Kanai and M. Shibasaki.
Tetrahedorn  2010,  66,  6569-6584.
Direct catalytic asymmetric aldol reactions of thioamides: toward a stereocontrolled
synthesis of 1,3-polyols.
M. Iwata, R. Yazaki, Y. Suzuki, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc.  2009,  131,  18244-18245.
Construction of contiguous tetrasubstituted chiral carbon stereocenters via direct
catalytic asymmetric aldol reaction of α-isothiocyanato esters with ketones.
T. Yoshino, H. Morimoto, G. Lu, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc.  2009,  131,  17082.
Inventing and understanding catalytic, enantioselective reactions.
M. Shibasaki, N. Kumagai and T. Mashiko.
Curr. Opin. Drug Discov. Devel.  2009,  12,  862-875.
Managing highly coordinative substrates in asymmetric catalysis: a catalytic asymmetric amination with a lanthanum-based ternary catalyst.
T. Mashiko, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc.  2009,  131,  14990-14999.
anti-Selective catalytic asymmetric nitroaldol reaction via a heterobimetallic heterogeneous catalyst.
T. Nitabaru, A. Nojiri, M. Kobayashi, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc.  2009,  131,  13860-13869.
Recent progress in asymmetric bifunctional catalysis using multimetallic systems.
M. Shibasaki, M. Kanai, S. Matsunaga and N. Kumagai.
Accounts of Chemical Research  2009,  42,  1117-1127.
Catalytic asymmetric synthesis of α-alkylidene-β-hydroxy esters via dynamic kinetic
asymmetric transformation involving Ba-catalyzed direct aldol reaction.
A. Yamaguchi, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc.  2009,  131,  10842.
An alternative synthesis of Tamiflu (R): a synthetic challenge and the identification of a
ruthenium-catalyzed dihydroxylation route.
K. Yamatsugu, M. Kanai and M. Shibasaki.
Tetrahedron  2009,  65,  6017-6024.
Nucleophile generation via decarboxylation: asymmetric construction of contiguous
trisubstituted and quaternary stereocenters through a Cu(I)-catalyzed decarboxylative
Mannich-type reaction.
L. Yin, M. Kanai and M. Shibasaki.
J. Am. Chem. Soc.  2009,  131,  9610-9611.
A homodinuclear Mn(III)2-Schiff base complex for catalytic asymmetric 1,4-additions of
oxindoles to nitroalkenes.
Y. Kato, M. Furutachi, Z. H. Chen, H. Mitsunuma, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc.  2009,  131,  9168.
Design and synthesis of immobilized Tamiflu analog on resin for affinity chromatography.
Y. Kimura, K. Yamatsugu, M. Kanai, N. Echigo, T. Kuzuhara and M. Shibasaki.
Tetrahedron Lett.  2009,  50,  3205-3208.
Mixed La-Li heterobimetallic complexes for tertiary nitroaldol resolution.
K. Hara, S. Y. Tosaki, V. Gnanadesikan, H. Morimoto, S. Harada, M. Sugita,
N. Yamagiwa, S.Matsunaga and M. Shibasaki.
Tetrahedron  2009,  65,  5030-5036.
A heterobimetallic Ga/Yb-Schiff base complex for catalytic asymmetric α-addition of
isocyanides to aldehydes.
H. Mihara, Y. J. Xu, N. E. Shepherd, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc.  2009,  131,  8384.
Catalytic asymmetric synthesis of nitrogen-containing gem-bisphosphonates using a
dinuclear Ni2-Schiff base complex.
Y. Kato, Z. H. Chen, S. Matsunaga and M. Shibasaki.
Synlett  2009,  1635-1638.
Direct catalytic asymmetric Mannich-type reaction of thioamides.
Y. Suzuki, R. Yazaki, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed.  2009,  48,  5026-5029.
Enantioselective synthesis of SM-130686 based on the development of asymmetric Cu(I)F catalysis to access 2-oxindoles containing a tetrasubstituted carbon.
D. Tomita, K. Yamatsugu, M. Kanai and M. Shibasaki.
J. Am. Chem. Soc.  2009,  131,  6946.
Catalytic asymmetric synthesis of chiral tertiary organoboronic esters through conjugate boration of β-substituted cyclic enones.
I. H. Chen, L. Yin, W. Itano, M. Kanai and M. Shibasaki.
J. Am. Chem. Soc.  2009,  131,  11664.
Sequential regulation of DOCK2 dynamics by two phospholipids during deutrophil
chemotaxis.
A. Nishikimi, H. Fukuhara, W. J. Su, T. Hongu, S. Takasuga, H. Mihara, Q. H. Cao,
F. Sanematsu, M. Kanai, H. Hasegawa, Y. Tanaka, M. Shibasaki, Y. Kanaho, T. Sasaki,
M. A. Frohman and Y. Fukui.
Science  2009,  324,  384-387.
Two methods for catalytic generation of reactive enolates promoted by a chiral poly Gd
complex: application to catalytic enantioselective protonation reactions.
M. Morita, L. Drouin, R. Motoki, Y. Kimura, I. Fujimori, M. Kanai and M. Shibasaki.
J. Am. Chem. Soc.  2009,  131,  3858.
Linking structural dynamics and functional diversity in asymmetric catalysis.
A. Nojiri, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc.  2009,  131,  3779-3784.
Direct catalytic asymmetric addition of allyl cyanide to ketones.
R. Yazaki, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc.  2009,  131,  3195-3197.
A stable homodinuclear biscobalt(III)-Schiff base complex for catalytic asymmetric
1,4-addition reactions of β-keto esters to alkynones.
Z. Chen, M. Furutachi, Y. Kato, S. Matsunaga and M. Shibasaki.
Angew. Chem. Int. Ed.  2009,  48,  2218-2220.
Direct catalytic asymmetric aldol reaction of β-keto esters with formaldehyde promoted by a dinuclear Ni2-Schiff base complex.
S. Mouri, Z. H. Chen, S. Matsunaga and M. Shibasaki.
Chemical Communications  2009,  5138-5140.
Catalytic asymmetric synthesis of 2,2-disubstituted oxetanes from ketones by using a
one-pot sequential addition of sulfur ylide.
T. Sone, G. Lu, S. Matsunaga and M. Shibasaki.
Angew. Chem. Int. Ed.  2009,  48,  1677-1680.
Direct anti-selective catalytic asymmetric Mannich-type reactions of α-ketoanilides for
the synthesis of γ-amino amides and azetidine-2-amides.
Y. J. Xu, G. Lu, S. Matsunaga and M. Shibasaki.
Angew. Chem. Int. Ed.  2009,  48,  3353-3356.
A synthesis of Tamiflu by using a barium-catalyzed asymmetric Diels-Alder-type
Reaction.
K. Yamatsugu, L. Yin, S. Kamijo, Y. Kimura, M. Kanai and M. Shibasaki.
Angew. Chem. Int. Ed.  2009,  48,  1070-1076.
Asymmetric reductive Mannich reaction to ketimines catalyzed by a Cu(I) complex.
Y. Du, L. W. Xu, Y. Shimizu, K. Oisaki, M. Kanai and M. Shibasaki.
J. Am. Chem. Soc.  2008,  130,  16146-16147.
Cu(I)-catalyzed hetero-Diels-Alder reaction between Danishefsky-type siloxy dienes and
ketones.
I. H. Chen, K. Oisaki, M. Kanai and M. Shibasaki.
Org. Lett.  2008,  10,  5151-5154.
Direct catalytic asymmetric addition of allylic cyanides to ketoimines.
R. Yazaki, T. Nitabaru, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc.  2008,  130,  14477.
Lewis base assisted Brønsted base catalysis: bidentate phosphine oxides as activators and modulators of Brønsted basic lanthanum-aryloxides.
H. Morimoto, T. Yoshino, T. Yukawa, G. Lu, S. Matsunaga and M. Shibasaki.
Angew. Chem. Int. Ed.  2008,  47,  9125-9129.
Catalytic conjugate addition of cyanide to enones: Cooperative catalysis of Ni(0) and
Gd(OTf)3.
Y. Tanaka, M. Kanai and M. Shibasaki.
Synlett  2008,  2295-2298.
Direct catalytic asymmetric Mannich-type reaction of β-keto phosphonate using a dinuclear
Ni2-Schiff base complex.
Z. Chen, K. Yakura, S. Matsunaga and M. Shibasaki.
Org. Lett.  2008,  10,  3239-3242.
Asymmetric synthesis of tertiary alcohols and α-tertiary amines via Cu-catalyzed C-C bond formation to ketones and ketimines.
M. Shibasaki and M. Kanai.
Chemical Reviews  2008,  108,  2853-2873.
An improved lanthanum catalyst system for asymmetric amination: toward a practical
asymmetric synthesis of AS-3201 (ranirestat).
T. Mashiko, N. Kumagai and M. Shibasaki.
Org. Lett.  2008,  10,  2725-2728.
Strategies for constructing diverse chiral environments in multimetallic bifunctional
asymmetric catalysis.
M. Shibasaki, S. Matsunaga and N. Kumagai.
Synlett  2008,  1583-1602.
Stereodivergent catalytic doubly diastereoselective nitroaldol reactions using
heterobimetalic complexes.
Y. Sohtome, Y. Kato, S. Handa, N. Aoyama, K. Nagawa, S. Matsunaga and
M. Shibasaki.
Org. Lett.  2008,  10,  2231-2234.
Direct catalytic asymmetric Mannich-type reactions of γ-butenolides: effectiveness of
Brønsted acid in chiral metal catalysis.
A. Yamaguchi, S. Matsunaga and M. Shibasaki.
Org. Lett.  2008,  10,  2319-2322.
A catalytic enantioselective conjugate addition of cyanide to enones.
Y. Tanaka, M. Kanai and M. Shibasaki.
J. Am. Chem. Soc.  2008,  130,  6072.
Asymmetric catalysis via dynamic substrate/ligand/rare earth metal conglomerate.
A. Nojiri, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc.  2008,  130,  5630.
Sc3+-catalyzed aldol-type additions of N-benzoylcyclopropanecarboxamides via
iodide-mediated ring-opening: stereoselective synthesis of γ-lactams.
S. H. Wiedemann, H. Noda, S. Harada, S. Matsunaga and M. Shibasaki.
Org. Lett.  2008,  10,  1661-1664.
Catalytic asymmetric synthesis of 2,2-disubstituted terminal epoxides via
dimethyloxosulfonium methylide addition to ketones.
T. Sone, A. Yamaguchi, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc.  2008,  130,  10078.
Synthetic strategies for oseltamivir phosphate.
M. Shibasaki and M. Kanai.
Eur. J. Org. Chem.  2008,  1839-1850.
Oseltamivir enhances hippocampal network synchronization.
A. Usami, T. Sasaki, N. Satoh, T. Akiba, S. Yokoshima, T. Fukuyama, K. Yamatsugu,
M. Kanai, M. Shibasaki, N. Matsuki and Y. Ikegaya.
J. Pharm. Sci.  2008,  106,  659-662.
A bench-stable homodinuclear Ni2-Schiff base complex for catalytic asymmetric synthesis of
α-tetrasubstituted anti-α,β-diamino acid surrogates.
Z. H. Chen, H. Morimoto, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc.  2008,  130,  2170.
P-glycoprotein restricts the penetration of oseltamivir across the blood-brain barrier.
A. Ose, H. Kusuhara, K. Yamatsugu, M. Kanai, M. Shibasaki, T. Fujita,
A. Yamamoto and Y. Sugiyama.
Drug Metabolism and Disposition  2008,  36,  427-434.
A method for the synthesis of an oseltamivir PET tracer.
M. Morita, T. Sone, K. Yamatsugu, Y. Solitome, S. Matsunaga, M. Kanaia,
W. B. Yasuyoshi and M. Shibasaki.
Bioorganic & Medicinal Chemistry Letters.  2008,  18,  600-602.
Multimetallic bifunctional asymmetric catalysis based on proximity effect control.
S. Matsunaga and M. Shibasaki.
Bulletin of the Chemical Society of Japan.  2008,  81,  60-75.
A catalytic asymmetric anti-selective nitroaldol reaction with a neodymium-sodium
heterobimetallic complex.
T. Nitabaru, N. Kumagai and M. Shibasaki.
Tetrahedron Lett.  2008,  49,  272-276.
A heterobimetallic Pd/La/Schiff base complex for anti-selective catalytic asymmetric
nitroaldol reactions and applications to short syntheses of β-adrenoceptor agonists.
S. Handa, K. Nagawa, Y. Sohtome, S. Matsunaga and M. Shibasaki.
Angew. Chem. Int. Ed.  2008,  47,  3230-3233.
Catalytic asymmetric epoxidation of α,β-unsaturated phosphane oxides with a
Y(OiPr)3/biphenyldiol complex.
K. Hara, S. Y. Park, N. Yamagiwa, S. Matsunaga and M. Shibasaki.
Chem. Asian J.  2008,  3,  1500-1504.
Chiral γ-amino amide synthesis by heterobimetallic lanthanum/lithium/pybox-catalyzed direct asymmetric Mannich-type reactions of α-keto anilides.
G. Lu, H. Morimoto, S. Matsunaga and M. Shibasaki.
Angew. Chem. Int. Ed.  2008,  47,  6847-6850.
Chiral-catalyst-based convergent synthesis of HIV protease inhibitor GRL-06579A.
H. Mihara, Y. Sohtome, S. Matsunaga and M. Shibasaki.
Chem. Asian J.  2008,  3,  359-366.
A Dy3-catalyzed Mannich-type reactions of 1-methylcyclopropanecarboxylate-type donors for the stereoselective synthesis of pyrrolidines with quarternary stereocenteres.
H. Noda, S.H. Widemann, S. Matsunaga and M. Shibasaki.
Chem. Lett.  2008,  37,  1180-1181.
Catalytic enantioselective addition of terminal alkynes to aldehydes: preparation of
(S)-(-)-1, 3-diphenyl-2-propyn-1-ol and (S)-(-)-4-methyl-1-phenyl-2-pentyn-1, 4-diol.
R. Takita, S. Harada, T. Ohsima, S. Matsunaga and M. Shibasaki.
Org. Synth.  2008,  85,  118-130.
※前所属での業績も含む
*The papers published in previous lab are included.