Chemistry DivisionLaboratory of Synthetic Organic Chemistry

Publications

Laboratory HP

In2Q2: a new entry of 16-membered tetraazamacrocycle concatenating indole and quinoline units.
K. Kihara, T. Kobayashi, W. Xu, and N. Kumagai
Chem. Eur. J., 2024, 30, doi.org/10.1002/chem.202304176

Thiazoplanomicin, a new thiazolyl peptide antibiotic from the leaf-litter actinomycete Actinoplanes sp. MM794L-181F6.
Y. Takehana, H. Muramatsu, M. Hatano, Y. Ishizaki, M. Umekita, Y.Shibuya, C. Hayashi, T. Kimura, T. Takeuchi, K. Shimuta, R. Sawa, and M. Igarashi
J. Antibiot., 2024. doi: 10.1038/s41429-024-00783-7.

Direct catalytic asymmetric conjugate addition of benzofuran-3(2H)-ones to α,β-unsaturated thioamides: stereodivergent synthesis of rocaglaol.
S. Samanta, H. Noda,T. Watanabe, J. Cui, and M. Shibasaki
Angewandte Chemie International Edition, 2024, e202415805. doi: 10.1002/anie.202415805.

Enhanced anticancer activity of 7MeERT over Ertredin: a comparative study on cancer cell proliferation and NDUFA12 binding.
S. Atsumi, C. Nosaka, T. Onodera, H. Adachi, T. Watanabe, M. Kawada, M. Shibuya, S. I. Park, and H. J. Kwon
Biomolecules, 2024, 14, 1197. https://doi.org/10.3390/biom14091197

Copper-catalyzed direct asymmetric aldol reaction of glycine Schiff bases to access syn-β-hydroxy-α-amino esters.
T. Takeuchi and M. Shibasaki
Org. Lett., 2024, 26, 7981-7986. https://doi.org/10.1021/acs.orglett.4c03085

Catalytic asymmetric Mannich-type reaction of α‑haloacetonitriles.
A. Saito and M. Shibasaki
Org. Lett., 2024, 26, 7546-7550. https://doi.org/10.1021/acs.orglett.4c02505

Inhibition of kynurenine production by N, O-substituted hydroxylamine derivatives.
M. Iijima, Y. Otsuka, S. Ohba, and I. Momose
Bioorg. Med. Chem. Lett. 2024, 106, 129731

Direct catalytic enantioselective conjugate addition of α‑substituted benzyl nitriles to alkyl acrylates.
S. Samanta, J. Cui, Y. Otsuka, T. Watanabe, and M. Shibasaki
Org. Lett. 2024, https://doi.org/10.1021/acs.orglett.4c00427

Catalytic asymmetric vinylogous conjugate addition of butenolide to 2‑ester-substituted chromones: access to chiral chromanone lactones via trapping of a copper(I) enolate by trimethyl borate.
J. Cui, R. Oriez, S. Samanta, H. Noda, T. Watanabe, and M. Shibasaki
Organic Letters, 2023, https://doi.org/10.1021/acs.orglett.3c03503

Examining the effects of additives and precursors on the reactivity of rhodium alkyl nitrenes generated from substituted hydroxylamines.
H. Noda, Y. Asada, and M. Shibasaki
Front. Chem., 2023, 11, 1271896. (DOI: 10.3389/fchem.2023.1271896)

anti-selective synthesis of substituted β-homoprolines by rhodium alkyl nitrene C–H Insertion.
X. Tang, H. Noda, and M. Shibasaki
Synlett, 2023, DOI: 10.1055/a-2201-7267

Locking the conformation of a paddlewheel rhodium complex: design, synthesis, and applications in catalytic nitrene transfers.
X.Tang, H. Noda, and M. Shibasaki
Angewandte Chemie International Edition, 2023, e202311027, https://doi.org/10.1002/anie.202311027

Brønsted base-catalyzed direct 1,6-conjugate addition of butenolide to p-quinone methides.
J. Cui, S. Samanta, T. Watanabe, and M. Shibasaki
Asian Journal of Organic Chemistry, 2023, https://doi.org/10.1002/ajoc.202300176

Azo-tagged C4N4 fluorophores: unusual overcrowded structures and their application to fluorescent imaging.
M. Kohei, N. Takizawa, R. Tsutsumi, W. Xu, and N. Kumagai
Org. Biomol. Chem. 2023, 21, 2889-2893

Aprosamine derivatives active against multidrug-resistant gram-negative bacteria.
Y. Otsuka, E. Umemura, Y. Takamiya, T. Ishibashi, C. Hayashi, K. Yamada, M. Igarashi, M. Shibasaki, and Y. Takahashi
ACS Infectious Diseases, 2023, 9, 886-898

Less is more: N(BOH)2 configuration exhibits higher reactivity than the B3NO2 heterocycle in catalytic dehydrative amide formation.
C. R. Opie, H. Noda, M. Shibasaki, and N. Kumagai
2023. https://pubs.acs.org/doi/10.1021/acs.orglett.2c04382

Asymmetric syn-selective vinylogous addition of butenolides to chromones via Al-Li-BINOL catalysis.
S. Samanta, J. Cui, H. Noda, T. Watanabe, and M. Shibasaki
J. Org. Chem. 2023, 88, 1177-1184. https://doi.org/10.1021/acs.joc.2c02731

A missing link in multisubstituted pyrrolidines: remote stereocontrol forged by rhodium-alkyl nitrene.
X. Tang, R. K. Tak, H. Noda, and M. Shibasaki
Angew. Chem. Int. Ed. 2022, 61, doi: 10.1002/anie.202212421

Targeting the ATG5-ATG16L1 protein-protein interaction with a hydrocarbon-stapled peptide derived from ATG16L1 for autophagy inhibition.
J. Cui, Y. Ogasawara, I. Kurata, K. Matoba, Y. Fujioka, N. N. Noda, M. Shibasaki, and T. Watanabe
J. Am. Chem. Soc., 2022. 144. doi: 10.1021/jacs.2c07648

Diastereoselective direct catalytic asymmetric Mannich-type reactions of alkylnitriles with a Ni(II)-carbene complex.
S. Adachi, A. Saito, and M. Shibasaki
Org. Lett., 2022, 24, 3901-3906. doi.org/10.1021/acs.orglett.2c01624

Concise and stereodivergent approach to chromanone lactones through copper-catalyzed asymmetric vinylogous addition of siloxyfurans to 2-ester-substituted chromones.
J. Cui, R. Oriez, H. Noda, T. Watanabe and M. Shibasaki
Angew. Chem. Int. Ed., 61, 2022, e202203128 (doi: 0.1002/anie. 202203128)

Rediscovery of 4-trehalosamine as a biologically stable, mass-producible, and chemically modifiable trehalose analog.
S. Wada, H. Arimura, M. Nagayoshi, R. Sawa, Y. Kubota, K. Matoba, C. Hayashi, Y. Shibuya, M. Hatano, Y. Takehana, S. Ohba, Y. Kobayashi, T. Watanabe, M. Shibasaki, and M. Igarashi
Advanced Biology 2022, 6, 2101309, https://doi.org/10.1002/adbi. 202101309

Imbuing an old heterocycle with the power of modern catalysis: an isoxazolidin-5-one story.
H. Noda
Chem. Pharm. Bull. 2021, 69, 1160-1169

Synthesis and structure-activity relationship study of intervenolin, an antitumor and anti-helicobacter pylori quinolone natural product.
T. Watanabe
Heterocycles. 2021, 102, 1894-1937.

Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment
J. Yoshida, T. Ohishi, H. Abe, S. Ohba, H. Inoue, I. Usami, M. Amemiya, R. Oriez, C. Sakashita, S. Dan, M. Sugawara, T. Kawaguchi, J. Ueno, Y. Asano, A. Ikeda, M. Takamatsu, G. Amori, Y. Kondoh, K. Honda, H. Osada, T. Noda, T. Watanabe, T. Shimizu, M. Shibasaki, and M. Kawada.
iScience, 2021, 24, 103497 doi.org/10.1016/ j.isci.2021.103497

Generation and application of Cu-bound alkyl nitrene for the catalyst-controlled synthesis of cyclic β-amino acids.
R. J. Tak, F. Amemiya, H. Noda and M. Shibasaki
Chemical Science., 2021, 12, 7809-7817.

Strategic synthesis of asymmetrically substituted C4N4 fluorophores.
W. Xu, M. Kohei, M. Shibasaki and N. Kumagai.
Synthesis, 2021, 53, 3355-3360.

Ligand-enabled, copper-catalyzed electrophilic amination for the asymmetric synthesis of β-amino acids
R. K. Tak, H. Noda,and M. Shibasaki.
Org. Lett. 2021, 23, 8617–8621.

Direct catalytic asymmetric addition of aklylnitriles to aldehydes with designed Ni-carbene complexes.
A. Saito, S. Adachi, N. Kumagai and M. Shibasaki
Angew. Chem. Int. Ed., 2021, 60(16), 8739-8743.

Catalyst-controlled chemoselective nitrene transfers
H. Noda, X. Tang and M. Shibasaki.
Helv. Chim. Acta 2021, 104, e2100140.

Highly enantio- and diastereoselective synthesis of 1,2,3-trisubstituted cyclopropanes from α,β-unsaturated amides and stabilized sulfur ylides catalyzed by a chiral copper(I) complex
S. K. Pagire, N. Kumagai and M. Shibasaki.
ACS Catal. 2021, 11, 11597-11606.

Androprostamine A: a unique antiprostate cancer agent.
Y. Yamazaki, H. Abe, C. Sakashita, SI. Ohba, T. Watanabe, I. Momose and M. Kawada
J. Antibiot., 2021, 74, 717-725.

Catalytic asymmetric total synthesis of leucinostatin A
T. Watanabe, H. Abe and M. Shibasaki
Chem. Rec., 2021, 21, 175-187.

Recent advances in the catalytic asymmetric synthesis of β2-and β2,2-amino acids.
H. Noda and M. Shibasaki
Eur. J. Org. Chem., 16, 2350-2361, 2020. https://doi.org/10.1002/ejoc.201901596

特異なB3NO2組成6員環を有する複核ホウ素ヘテロ環の設計、合成、およびアミド化触媒への展開
野田秀俊、柴﨑正勝、熊谷直哉
有機合成化学協会誌　2020, 78, 971-978.

Introduction of a 7-aza-6-MeO-indoline auxiliary in Lewis-acid/photoredox cooperative catalysis: highly enantioselective aminomethylation of α,β-unsaturated amides.
S. Kisan Pagire, N. Kumagai and M. Shibasaki
Chemical Science, 2020, 221, 766-774.

(2R,3S)-3,4,4,4-Tetrafluorovaline: a fluorinated bioisostere of isoleucine.
L. Brewitz, H. Noda, N. Kumagai and M. Shibasaki
Eur. J. Org., 2020, 2020, 1745-1752.

Z-enolate geometry in thioamide aldol reaction illuminated by 7-azaindoline auxiliary.
R. Pluta, Z. Li, N. Kumagai and M. Shibasaki
Org. Lett., 2020, 22, 791-794. https://doi.org/10.1021/acs.orglett.9b04120

Cyanomethylation of β-alkoxyaldehydes: Toward a short synthesis of atorvastatin.
R. Kumar, H. Noda, and M. Shibasaki
Asian J. Org. Chem., 2020, 9, 57-60. https://doi.org/10.1002/ajoc.201900595

Direct catalytic asymmetric and anti-selective vinylogous addition of butenolides to chromones.
J. Cui, N. Kumagai, T. Watanabe and M. Shibasaki
Chemical Science., 2020, 11, 7170-7176.

ボロン酸を利用したがん分子標的治療薬の開発
百瀬 功、渡辺 匠
ファルマシア, 2020, 56, 416-420.

The different faces of [Ru(bpy)3Cl2] and fac [Ir(ppy)3] photocatalysts: redox potential controlled synthesis of sulfonylated fluorenes and pyrroloindoles from unactivated olefins and sulfonyl chlorides.
S. K. Pagire, N. Kumagai and M. Shibasaki
Org. Lett., 2020, 22, 7853-7858.

O-Benzoylhydroxylamines as alkyl nitrene precursors: synthesis of saturated N-heterocycles from primary amines.
H. Noda, Y. Asada and M. Shibasaki
Org. Lett., 2020, 22, 8769-8773.

Direct catalytic asymmetric addition of α-fluoronitriles to aldehydes.
P. V. Balaji, Z. Li, A. Saito, N. Kumagai and M. Shibasaki
Chem. Eur. J., 2020, 26, 15524-15527.

Catalytic asymmetric 1,3-dipolar cycloaddition of α,β-unsaturated amide and azomethine imine.
Z. Li, N. Kumagai and M. Shibasaki
Chem. Pharm. Bull., 2020, 68, 552-554.

Inhibition of mitochondria ATP synthase suppresses prostate cancer growth through reduced insulin-like growth factor-1 secretion by prostate stromal cells.
T. Ohishi, H. Abe, C. Sakashita, U. Saqib, MS. Baig, SI. Ohba, H. Inoue, T. Watanabe, M. Shibasaki and M. Kawada.
Int J Cancer. 2020, 146, 3474-3484. doi: 10.1002/ijc.32959.

Solvent-dependent enantiodivergence in anti-selective catalytic asymmetric nitroaldol reactions.
T. Karasawa, A. Saito, N. Kumagai and M. Shibasaki
Org. Lett. 2019, 2019, 21, 3581-3583

All non‐carbon B3NO2 exotic heterocycles: synthesis, dynamics, and catalysis.
C. Opie, M. Noda, M. Shibasaki and N. Kumagai
Chem. Eur. J. 2019, 25, 4648-4653

A C4N4 diaminopyrimidine fluorophore.
H. Noda, Y. Asada, T. Maruyama, N. Takizawa, N. N. Noda, M. Shibasaki and N. Kumagai
Chem. Eur. J. 2019, 25, 4299-4304

Catalytic asymmetric synthesis of syn-aldols with methyl ketone functionality and anti-aldols with a thioamide group.
Y. Ota, Z. Li, N. Kumagai and M. Shibasaki.
Synlett 2019, 30, 620-624

Direct catalytic asymmetric aldol reaction of α-alkoxyamides to α-fluorinated ketones.
R. Pluta, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2019, 58, 2459-2463

Neighboring protonation univeils lewis acidity in the B3NO2 heterocycle.
H. Noda, Y. Asada, M. Shibasaki and N. Kumagai.
J. Am. Chem. Soc. 2019, 141, 1546-1554

7-Azaindoline auxiliary: a versatile attachment facilitating enantioselective C-C bond-forming catalysis.
N. Kumagai and M. Shibasaki
Synthesis 2019, 51, 185-193

A fluorogenic C4N4 probe for azide-based labelling.
H. Noda, Y. Asada, M. Shibasaki and N. Kumagai
Org. Biomol. Chem. 2019, 17, 1813-1816

Direct catalytic asymmetric mannich-type reaction of an α-Cf3 amide to isatin imines.
J. -S. Yu, H. Noda, N. Kumagai and M. Shibasaki
Synlett. 2019, 30, 488-492

Achiral trisubstituted thioureas as secondary ligands to Cu(I) catalysts: direct catalytic asymmetric addition of α-fluoronitriles to imines.
P. V. Balaji, L. Brewitz, N. Kumagai and M. Shibasaki
Angew. Chem. Int. Ed. 2019, 58, 2644-2648

Traceless electrophilic amination for the synthesis of unprotected cyclic β amino acids.
J.-S. Yu, M. Espinosa, H. Noda and M. Shibasaki
J. Am. Chem. Soc., 2019, 141, 10530-10537.

Chemical studies on bioactive natural products directed toward development of novel antiinfective and anticancer medicines.
T. Watanabe
Chem. Pharm. Bull., 2019, 67, 620-631.

Lewis base assisted lithium BrØnsted base catalysis: a new entry for catalytic asymmetric synthesis of β2,2-amino acids.
F. Amemiya, H. Noda and M. Shibasaki
Chem. Pharm. Bull., 2019, 67, 1046-1049.

Direct catalytic asymmetric addition of acetonitrile to aldimines.
A. Saito, N. Kumagai and M. Shibasaki
Org. Lett., 2019, 21, 8187-8190.

On the nitrogen inversion of isoxazoldin-5-ones.
H. Noda and M. Shibasaki
Chem. Pharm. Bull., 2019, 67, 1248-1249.

A thirst for enantioselectivity in catalytic addition of alkylnitriles.
N. Kumagai and M. Shibasaki
Chem. Lett., 2019, 48, 1322-1327.

TriQuinoline.
S. Adachi, M. Shibasaki and N. Kumagai
Nat. Commun., 2019, 10, Article number: 3820.

Synthesis of unprotected spinocyclic β-prolines and β-homoprolines by Rh catalyzed C-H insertion.
M. Espinosa, H. Noda and M. Shibasaki
Org. Lett., 2019, 21, 9286-9290.

Intervenolin suppresses gastric cancer cell growth through the induction of TSP-1 secretion from fibroblast-like stromal cells.
J. Yoshida, H. Abe,T. Watanabe and M. Kawada
Oncol. Lett. 2018, 16, 6777-6785

anti-Selective catalytic asymmetric nitroaldol reaction of α-keto esters; Intriguing solvent effect, flow reaction, and synthesis of APIs
T. Karasawa, R. Oriez, N. Kumagai and M. Shibasaki
J. Am. Chem. Soc. 2018, 140, 12290-12295

Exploiting β‐Amino acid enolates in direct catalytic diastereo‐ and enantioselective C‐C bond forming reactions.
J.-S. Yu, H. Noda and M. Shibasaki
Chem. Eur. J. 2018, 24, 15796-15800

Structure-activity relationship study of Leucinostatin A, a modulator of tumor-stroma interaction.
H. Abe, M. Kawada, C. Sakashita, T. Watanabe and M. Shibasaki
Tetrahedoron 2018, 74, 5129-5137

Anti-influenza virus activity of a salcomine derivative mediated by inhibition of viral RNA synthesis.
N. Takizawa, T. Kimura, T. Watanabe and M. Shibasaki
Arch. Virol. 2018, 163, 1607-1614

New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and lycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells.
S. Atsumi, C. Nosaka, H. Adachi, T. Kimura, Y. Kobayashi, H. Takada, T. Watanabe, S. Ohba, H. Inoue, M. Kawada, M. Shibasaki, M. Shibuya.
BMC Cancer. 2016, 19, doi: 10.1186/s12885-016-2521-9

Direct catalytic asymmetric 1,6-conjugate addition of amides to p-quinone methides.
Z. Sun, B. Sun, N. Kumagai and M. Shibasaki
Org. Lett. 2018, 20, 3070-3073

Direct enolization chemistry of 7-azaindoline amides: A case study of bis(tetrahydrophosphole)-type ligands.
Z. Li, H. Noda, N. Kumagai and M. Shibasaki
Tetrahedron, 2018, 74, 3301-3305

Direct catalytic asymmetric aldol reaction of α-vinyl acetamide.
T. Takeuchi, N. Kumagai and M. Shibasaki
J. Org. Chem. 2018, 83, 5851-5858

Monotherapy with a novel intervenolin derivative, AS-1934, is an effective treatment for Helicobacter pylori infection.
T. Ohishi, T. Masuda, H. Abe, C. Hayashi, H. Adachi, S. Ohba, M. Igarashi, T. Watanabe, H. Mimuro, E. Amalia, DK. Inaoka, K. Mochizuki, K. Kita, M. Shibasaki and M. Kawada
Helicobacter 2018, 23, e12470

Catalytic asymmetric synthesis of α-trifluoromethylated carbinols: A case study of tertiary propargylic alcohols.
H. Noda, N. Kumagai and M.Shibasaki
Asian J. Org. Chem. 2018, 7, 599-612

Conquering amide planarity: structural distortion and its hidden reactivity.
S. Adachi, N. Kumagai and M.Shibasaki
Tetrahedron Lett. 2018, 59, 1147-1158

Catalytic oligopeptide synthesis.
Z. Liu, H. Noda, M. Shibasaki and N. Kumagai
Org. Lett. 2018, 20, 612-615

Direct catalytic asymmetric mannich-type reaction en route to α-hydroxy-β-amino acid derivatives.
B. Sun, R. Pluta, N. Kumagai and M. Shibasaki
Org. Lett. 2018, 20, 526-529

Heterogeneous heterobimetallic catalysis enabling expeditious access to CF3 containing vic-amino alcohols.
T. Karasawa, N. Kumagai and M. Shibasaki
Org. Lett. 2018, 20, 308-311

Direct catalytic asymmetric aldol reaction of thioamide with an α-vinyl appendage.
J. Cui, A. Ohtsuki, T. Watanabe, N. Kumagai and M. Shibasaki
Chem. Eur. J. 2018, 24, 2598-2601

Phenazine carboxylic acid and its derivative induce osteoblast differentiation in preosteoblastic MC3T3-E1 cells but adipocyte differentiation in pluripotent mesenchymal C3H10T1/2 cells.
S. Sakamoto, T. Watanabe, Y. Kohda, M. Iijima, R. Sawa, M. Okada, H. Adachi, Y. Nishimura, M. Kawada
J. Antibiot. 2017, 70, 1146-1149

Quaternary β2,2 -amino acids: Catalytic asymmetric synthesis and incorporation into peptides via Fmoc-SPPS.
J.-S. Yu, H. Noda and M. Shibasaki
Angew. Chem. Int. Ed. 2018, 57, 818-822

Catalytic enantioselective addition of diethyl phosphite to N-thiophosphinoyl ketimines: preparation of (R)-diethyl(1-amino-1-phenylethyl)phosphonate.
S. Lin, Y. Otsuka, L. Yin, N. Kumagai and M. Shibasaki
Org. Synth. 2017, 94, 313-331

Thieme chemistry journals awardees – Where are they now?
Bis(2-pyridyl)amides as readily cleavable amides under catalytic, neutral, and room-temperature conditions.
S. Adachi, N. Kumagai and M. Shibasaki
Synlett 2018, 29, 301-305

Structural and computational investigation of intramolecular N−H interactions in α- and β-fluorinated 7-azaindoline amides.
L. Brewitz, H. Noda, N. Kumagai and M. Shibasaki
Eur. J. Org. Chem. 2018, 2018, 714-722

Synthetic studies of viridiofungins, broad-spectrum antifungal agents and serine palmitoyl transferase inhibitors.
N. Kumagai and M. Shibasaki
J. Antibiot. 2018, 71, 53-59

Synthesis of caprazamycins and related natural products.
T. Watanabe
Heterocycles 2017, 95, 662-693

ATP Depletion Assay Led to the Isolation of New 36-Membered Polyol Macrolides Deplelides A and B from Streptomyces sp. MM581-NF15.
T. Takeuchi, M. Hatano, M. Umekita, C. Hayashi, S. Wada, M. Nagayoshi, R. Sawa, Y. Kubota, M. Kawada, M. Igarashi and M. Shibasaki
Org. Lett. 2017, 19, 4207-4210

Catalytic asymmetric total synthesis and stereochemical revision of leucinostatin A, a modulator of tumor-stroma interaction.
H. Abe, H. Ouchi, C. Sakashita, M. Kawada, T. Watanabe and M. Shibasaki
Chem. Eur. J. 2017,23, 11792-11796

Direct catalytic asymmetric aldol addition an α-CF3 amide to arylglyoxal hydrates.
A. Matsuzawa, H. Noda, N. Kumagai and M. Shibasaki
J. Org. Chem. 2017, 82, 8304-8308

Photocatalytic α-acylation of ethers.
Z. Sun, N. Kumagai and M. Shibasaki
Org. Lett. 2017, 19, 3727-3730

α,β-Unsaturated amides as dipolarophiles: catalytic asymmetric exo-selective 1,3-dipolar cycloaddition with nitrones.
M. Zhang, N. Kumagai and M. Shibasaki
Chem. Eur. J. 2017, 23, 12450-12455

Direct N-acylation of sulfoximines with carboxylic acids catalyzed by the B3NO2 heterocycle.
H. Noda, Y. Asada, M. Shibasaki and N. Kumagai
Chem. Comm. 2017, 54, 7447-7450

α-Halo amides as competent latent enolates: direct catalytic asymmetric Mannich-type reaction.
B. Sun, P. Balaji, N. Kumagai and M. Shibasaki
J. Am. Chem. Soc. 2017, 139, 8295-8301.

Leptolyngbyolides, cytotoxic macrolides from the marine cyanobacterium leptolyngbya sp.:isolation, biological activity, and catalytic asymmetric total synthesis.
J. Cui, M. Morita, O. Ohno, T. Kimura, T. Teruya, T. Watanabe, K. Suenaga and M. Shibasaki
Chem. Eur. J. 2017, 23, 8500-8509.

Cu/Pd Synergistic dual catalysis: asymmetric α-allylation of α-CF3 amide.
A. Saito, N. Kumagai and M. Shibasaki
Angew. Chem. Int. Ed. 2017, 56, 5551-5555.

Tyropeptins, proteasome inhibitors produced by Kitasatospora sp. MK993-dF2.
I. Momose and T. Watanabe
J. Antibiot. 2017, 70, 542-550.

Catalytic asymmetric synthesis of CF3-substituted tertiary propargylic alcohols via direct aldol reaction of α-N3 amide.
H. Noda, F. Amemiya, K. Weidner, N. Kumagai, and M. Shibasaki
Chem. Sci. 2017, 8, 3260-3269

Uique physicochemical and catalytic properties dictated by the B3NO2 ring system.
H. Noda, M. Furutachi, Y. Asada, M. Shibasaki and N. Kumagai
Nat. Chem. 2017, 9, 571-577

Asymmetric flow catalysis: mix-and-go solid-phase Nd/Na catalyst for expeditious enantioselective access to a key intermediate of AZD7594.
A. Nonoyama, N. Kumagai and M. Shibasaki
Tetrahedron 2017, 73, 1517-1521

Reversible stereoselective folding/unfolding fueled by the interplay of photoisomerism and hydrogen bonding.
C. R. Opie, N. Kumagai and M. Shibasaki
Angew. Chem. Int. Ed. 2017, 56, 3349-3353

Direct catalytic asymmetric aldol reaction of α-alkylamides.
Z. Liu, T. Takeuchi, R. Pluta, F. Arteaga, N. Kumagai and M. Shibasaki
Org. Lett. 2017, 19, 710-713

Catalytic asymmetric synthesis of 2,3,3,3,-tetrafluoro-2-methyl-1-arylpropan-1-amines as useful building blocks for SAR-studies.
L. Brewitz, N. Kumagai and M. Shibasaki.
J. Fluor. Chem. 2017, 194, 1-7.

Strategic immobilization of molecular catalysts onto carbon nanotubes via noncovalent interaction for catalytic organic transformations.
N. Kumagai and M. Shibasaki.
Isr. J. Chem. 2017, 57, 270-278.

Enantioselective synthesis of α,α-disubstituted α-amino acids via direct catalytic asymmetric addition of acetonitrile to α-iminoesters.
S. Lin, N. Kumagai and M. Shibasaki.
Org. Biomol. Chem. 2016. 14, 9725-9730.

Pyramidalization/twisting of the amide functionality via remote steric congestion triggered by metal coordination.
S. Adachi, N. Kumagai and M. Shibasaki.
Chem. Sci. 2017, 8, 85-90.

Catalytic asymmetric synthesis of the C1-C15 segment of spirastrellolide A.
Y. Sahara, J. Cui, M. Furutachi, J. Chen, T. Watanabe and M. Shibasaki.
Synthesis. 2017, 49, 69-75.

Nucleophilic and electrophilic activation of non-heteroaromatic amides in atom economical asymmetric catalysis.
N. Kumagai and M. Shibasaki.
Chem. Eur. J. 2016, 22, 15192-15200.

A career in catalysis: Masakatsu Shibasaki
N. Kumagai, M. Kanai and H. Sasai
ACS Catal. 2016, 6, 4699-4709.

Catalytic asymmetric synthesis of CPZEN-45.
T. Takeuchi, H. Abe, T. Watanabe and M. Shibasaki.
Tetrahedron Lett. 2016, 57, 2901-2904.

Direct catalytic asymmetric mannich-type reaction of alkylamides.
F. Arteaga, Z. Liu, L. Brewitz, J. Chen, B. Sun, N. Kumagai and M. Shibasaki.
Org. Lett. 2016, 18, 2391-2394.

Synthesis of androprostamine A and resormycin.
H. Abe, Y. Yamazaki, C. Sakashita, I. Momose, T. Watanabe and M. Shibasaki.
Chem. Pharm. Bull. 2016, 64, 982-987.

キラリティーを制御して炭素をつなげる －天然物の触媒的不斉全合成
柴﨑正勝、渡辺 匠
化学 2016, 71, 23-26.

Preparation of Nd/Na heterogeneous catalyst from bench-stable and inexpensive Nd salt for an anti-selective catalytic asymmetric nitroaldol reaction.
A. Nonoyama, K. Hashimoto, A. Saito, N. Kumagai and M. Shibasaki.
Tetrahedron Lett. 2016, 57, 1815-1819.

Electrophilic activation of α,β-unsaturated amides; catalytic asymmetric vinylogous conjugate addition of unsaturated γ-butyrolactones
M. Zhang, N. Kumagai and M. Shibasaki.
Chem. Eur. J. 2016, 22, 5525-5529.

Direct catalytic asymmetric mannich-type reaction of α,β-unsaturated γ-butyrolactam to ketimines.
S. Lin, N. Kumagai and M. Shibasaki.
Chem. Eur. J. 2016, 22, 3296-3299.

Catalytic asymmetric synthesis of key intermediate for scytophycin C
J. Cui, T. Watanabe and M. Shibasaki.
Tetrahedron Lett. 2016, 57, 446-448.

Coccoquinones A and B, new anthraquinone derivatives produced by Staphylotrichum coccosporum PF1460
D. Tatsuda, M. Amemiya, R. Sawa, K. Sumiyoshi, T. Watanabe, I. Momose, M. Kawada, A. Nomoto and M. Shibasaki.
J. Antibiot. 2016, 69, 176-178.

BNew anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells.
S. Atsumi, C. Nosaka, H. Adachi, T. Kimura, Y. Kobayashi, H. Takada, T. Watanabe, S. Ohba, H. Inoue, M. Kawada, M. Shibasaki, M. Shibuya.
BMC Cancer., 19, 496, 2016.

Direct catalytic asymmetric mannich-type reaction of α-and β-fluorinated amides.
L. Brewitz, F. Arteaga, L. Yin, K. Alagiri, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2015, 137, 15929-15939.

Direct catalytic asymmetric mannich-type reaction of α-N3 amide.
Z. Sun, K. Widener, N. Kumagai and M. Shibasaki
Chem. Eur. J. 2015, 21, 17574-17577.

Stereoselective total synthesis of KAE609 via directcatalytic asymmetric alkynylation to ketimine.
H. Takada, N. Kumagai and M. Shibasaki.
Org. Lett. 2015, 17, 4762-4765

Synthesis and determination of absolute configuration of lentztrehalose A
M. Zhang, S. Wada, F. Amemiya, T. Watanabe and M. Shibasaki
Chem. Pharm. Bull. 2015, 63, 961-966.

医薬品の効率的不斉合成を志向した協奏機能型不斉触媒の開発
熊谷直哉、柴崎正勝
化学工業 2015, 66, 31-41

Managing the retro-pathway in direct catalytic asymmetric aldol reactions of thioamides.
Y. Bao, N. Kumagai and M. Shibasaki.
Chem. Sci. 2015, 6, 6124-6132

Direct catalytic asymmetric conjugate addition of saturated and unsaturated thioamides.
N. Majumdar, A. Saito, L. Yin, N. Kumagai and M. Shibasaki.
Org. Lett. 2015, 17, 3362-3365

Synthesis and structure-activity relationship study of NBRI16716B, an antitumor natural product.
H. Abe, C. Sakashita, M. Kawada, A. Nomoto, T. Watanabe and M. Shibasaki.
Chem. Pharm. Bull. 2015, 63, 463-468

Synthesis of caprazamycin B
H. Abe, P. Gopinath, G. Ravi, L. Wang, T. Watanabe and M. Shibasaki.
Tetrahedron Lett. 2015, 78, 3782-3785

Direct catalytic asymmetric mannich-type reaction of benzylisocyanide: stereoselective synthesis of 1,2-diarylethylenediamines.
K. Tamura, N. Kumagai and M. Shibasaki.
Eur J Org Chem. 2015, 3026-3031

Direct catalytic asymmetric aldol reaction of α-N₃ amide.
K. Weidner, Z. Sun, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2015，54，6236-6240

Quinofuracins A-E, produced by the fungus staphylotrichum boninense PF1444, show p53-dependent growth suppression.
D. Tatsuda, I. Momose, T. Someno, R. Sawa, Y. Kubota, M. Iijima, T. Kunisada, T. Watanabe, M. Shibasaki and A. Nomoto.
J. Nat. Prod. 2015,78，188-195

Catalytic asymmetric Mannich-type reaction of N-alkylidene α-aminoacetonitrile to ketimines.
S. Lin, Y. Kawato, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2015, 54, 5183-5186

A carbon nanotube confinement strategy to implement homogeneous asymmetric catalysis in the solid phase.
K. Hashimoto, N. Kumagai and M. Shibasaki.
Chem. Eur. J. 2015, 21,4262-4266.

Catalytic generation of α-CF₃ enolate: direct catalytic asymmetric mannich-type reaction of α-CF₃ amide.
L. Yin , L. Brewitz, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2014, 136, 17958-17961.

Recent advances in catalytic asymmetric C-C bond-forming reactions to ketimines promoted by metal-based catalysts.
N. Kumagai and M. Shibasaki.
Bull. Chem. Soc. Jpn. 2015, 88, 503-517

Antitumor effects of tyropeptin-boronic acid derivatives: new proteasome inhibitors.
I. Momose, H. Abe, T. Watanabe, S. Ohba, K. Yamazaki, S. Dan, T. Yamori, T. Masuda and
A. Nomoto
Cancer Sci. 2014, 105, 1609-1615.

Chromatography-free synthesis of Corey's intermediate for tamiflu.
M. Furutachi, N. Kumagai, T. Watanabe and M. Shibasaki.
Tetrahedron 2014, 70, 9113-9117.

Iterative direct aldol strategy for polypropionates: enantioselective total synthesis of (-)-membrenone A and B.
K. Alagiri, N. Kumagai and M. Shibasaki.
Org. Lett. 2014, 16, 5301-5303.

Design and synthesis of a bis(hydroxyphenyl)diamide bearing a pendant thiazolium unit; application to the catalytic asymmetric intramolecular Stetter reaction.
Y. Bao, N. Kumagai and M. Shibasaki.
Tetrahedron: Asymmetry. 2014, 25, 1401-1408.

Direct catalytic addition of alkylnitriles to aldehydes by transition Metal/NHC complexes.
---selected as a cover picture---
D. Sureshkumar, V. Ganesh, N. Kumagai and M. Shibasaki.
Chem-Eur.J. 2014, 20, 15723-15726.

Self-assembled asymmetric catalyst engaged in a continuous-flow platform: an anti-selective catalytic asymmetric nitroaldol reaction.
K. Hashimoto, N. Kumagai and M. Shibasaki.
Org. Lett. 2014, 16, 3496-3499.

Regiodivergent kinetic resolution of terminal and internal rac-aziridines with malonates under dinuclear Schiff base catalysis.
Y. Xu, K. Kaneko, M. Kanai, M. Shibasaki and S. Matsunaga.
J. Am. Chem. Soc. 136, 9190-9194.

Catalytic asymmetric total synthesis of (+)-caprazol.
P. Gopinath, L. Wang, H. Abe, G. Ravi, T. Masuda, T. Watanabe and M. Shibasaki.
Org. Lett. 2014, 16, 3364-3367.

A designed amide as an aldol donor in the direct catalytic asymmetric aldol reaction.
K. Weidner, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2014, 53, 6150-6154.

Concise enantioselective synthesis of δ,δ-disubstituted δ-valerolactones.
A. Saito, N. Kumagai and M. Shibasaki.
Tetrahedron Lett. 2014, 55, 3167-3171.

An enantioselective synthesis of the key intermediate for triazole antifungal agents; application to the aatalytic asymmetric synthesis of efinaconazole (Jublia®).
K. Tamura, N. Kumagai and M. Shibasaki.
J. Org. Chem. 2014, 79, 3272-3278.

Direct catalytic asymmetric vinylogous conjugate addition of unsaturated butyrolactones to α,β-unsaturated thioamides.
L. Yin, H. Takada, S. Lin, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2014, 53, 5327-5331.

硫黄含有物質を基質とするCooperative Asymmetric Catalysis
（2012年度有機合成化学協会 高砂香料国際賞「野依賞」受賞記念寄稿）
柴﨑正勝
The TAKASAGO Times 2013, 172, 26-31.

Recent advances in cooperative bimetallic asymmetric catalysis: dinuclear Schiff base complexes.
S. Matsunaga and M. Shibasaki.
Chem. Commun. 2014, 50, 1044-1057.

Direct aldol strategy in enantioselective total synthesis of thuggacin B.
A. Matsuzawa, C. R. Opie, N. Kumagai and M. Shibasaki.
Chem. Eur. J. 2014, 20, 67-71.

A modified preparation procedure for carbon nanotube-confined
Nd/Na heterobimetallic catalyst for anti-selective catalytic asymmetric nitroaldol reactions.
D. Sureshkumar, K. Hashimoto, N. Kumagai and M. Shibasaki.
J. Org. Chem. 2013, 78, 11494-11500.

Direct catalytic asymmetric addition of acetonitrile to N-thiophosphinoylimines.
Y. Kawato, N. Kumagai and M. Shibasaki.
Chem. Commun. 2013, 49, 11227-11229.

An enantioselective synthesis of voriconazole.
K. Tamura, M. Furutachi, N. Kumagai and M. Shibasaki.
J. Org. Chem. 2013, 78, 11396-11403.

Identification of octenal-related dA and dC adducts formed by reactions with a hemin-ω-6-fat peroxidation model system.
K. Kawai, Y. Kawasaki, Y. Kubota, T. Kimura, R. Sawa, T. Matsuda and H. Kasai.
Chem. Res. Toxicol. 2013, 26, 1554-1560.

医薬品合成の革新的な不斉触媒反応
─リレンザの純化学合成と再利用可能な触媒の開発
熊谷直哉、柴﨑正勝
化学 2013, 68, 12-17.

Catalytic asymmetric hydrophosphonylation of ketimines.
L. Yin, Y. Bao, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2013, 135, 10338-10341.

Synthesis of intervenolin, an antitumor natural quinolone with unusual substituents.
H. Abe, M. Kawada, H. Inoue, S. Ohba, A. Nomoto, T. Watanabe and M. Shibasaki.
Org. Lett. 2013, 15, 2124-2127.

Structure-activity relationship study of intervenolin derivatives:
synthesis, antitumor and anti-Helicobacter Pylori activities.
H. Abe, M. Kawada, H. Inoue, S. Ohba, T. Masuda, C. Hayashi, M. Igarashi,
A. Nomoto, T. Watanabe and M. Shibasaki.
Tetrahedron 2013, 69, 7608-7617.

Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2.
M. Kawada, H. Inoue, S. Ohba, M. Hatano, M. Amemiya, C. Hayashi, I. Usami, H. Abe, T. Watanabe, N. Kinoshita, M. Igarashi, T. Masuda, D. Ikeda and A. Nomoto.
J. Antibiot. 2013, 66, 543-548.

Direct catalytic asymmetric Mannich-type reaction of α-sulfanyl lactones.
S. Takechi, N. Kumagai and M. Shibasaki.
Org. Lett. 2013, 15, 2632-2635.

Direct catalytic asymmetric vinylogous Mannich-type reaction of
γ-butenolides with ketimines.
L. Yin, H. Takada, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2013, 52, 7310-7313.

Self-assembling neodymium/sodium heterobimetallic asymmetric catalyst confined in
carbon nanotube network.
T. Ogawa, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2013, 52, 6196-6201.

In situ manipulation of catalyst performance via photocontrolled
aggregation/dissociation state of the catalyst.
A. Nojiri, N. Kumagai and M. Shibasaki.
Chem. Commun. 2013, 49, 4628-4630.

Two approaches toward the formal total synthesis of oseltamivir
phosphate (Tamiflu): catalytic enantioselective three-component
reaction strategy and L-glutamic acid strategy.
K. Alagiri, M. Furutachi, K. Yamatsugu, N. Kumagai, T. Watanabe and M. Shibasaki.
J. Org. Chem. 2013, 78, 4019-4026.

Streamlined catalytic asymmetric synthesis of atorvastatin.
---selected as very important paper (VIP)---
Y. Kawato, S. Chaudhary, N. Kumagai and M. Shibasaki.
Chem. Eur. J. 2013, 19, 3802-3806.

Direct catalytic asymmetric alkynylation of ketoimines.
L. Yin, Y. Otsuka, H. Takada, S. Mouri, R. Yazaki, N. Kumagai and M. Shibasaki
Org. Lett. 2013, 15, 698-701.

Multimetallic Schiff base complexes as cooperative asymmetric catalysts.
S. Matsunaga and M. Shibasaki.
Synthesis 2013, 45, 421-437.

Amycolamicin: a novel broad-spectrum antibiotic inhibiting bacterial topoisomerase.
R. Sawa, Y. Takahashi, H. Hashizume,　K. Sasaki,　Y. Ishizaki,　M.Umekita,　M. Hatano,
H. Abe,　T. Watanabe,　N. Kinoshita,　Y. Homma, C. Hayashi,　K. Inoue,　S. Ohba,
T. Masuda,　 M. Arakawa,　Y. Kobayashi,　M. Hamada,　M. Igarashi,　H. Adachi,
Y. Nishimura and Y. Akamatsu.
Chem. Eur. J. 2012, 18, 15772-15781.

Direct catalytic asymmetric addition of allylic cyanides to aldehydes
for expeditious access to enantioenriched unsaturated
delta-valerolactones.
Y. Otsuka, H. Takada, S. Yasuda, N. Kumagai and M. Shibasaki.
Chem. Asian J. 2013, 8, 354-358.

原子効率と触媒的不斉合成
柴﨑正勝
有機合成化学会誌 2012, 70, 1073-1075.

Studies on catalytic enantioselective total synthesis of caprazamycin B:
construction of the western zone.
P. Gopinath, T. Watanabe and M. Shibasaki.
J. Org. Chem. 2012, 77, 9260-9267.

Asymmetric catalysis with bis(hydroxyphenyl)diamides/rare earth metal complexes.
N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2013, 52, 223-234.

Synthesis and assignment of the absolute configuration of an indenotryptoline bisindole alkaloid, BE-54017.
T. Kimura, S. Kanagaki, Y. Matsui, M. Imoto, T. Watanabe and M. Shibasaki.
Org. Lett. 2012, 14, 4418-4421.

Direct asymmetric α-allylation of ketones with allylic alcohols via Pd/enamine cooperative function.
S. Yasuda, N. Kumagai and M. Shibasaki.
Heterocycles 2012, 86(1), 747-757.

Catalytic chemical transformations with conformationally dynamic catalytic systems.
N. Kumagai and M. Shibasaki.
Catal. Sci. Technol. 2013, 3, 41-57.

Isolation and characterization of signamycine B, an antibiotic that targets the dimerization domain of histidine kinase WalK.
T. Watanabe, M. Igarashi, T. Okajima, E. Ishii, H. Kino, M. Hatano, R.Sawa,
M. Umekita, T. Kimura, S. Okamoto,Y. Eguchi, Y. Akamatsu and R. Utsumi.
Antimicrob. Agents Chemother. 2012, 56, 3657-3663.

Catalytic asymmetric conjugate addition of thiols to α,β-unsaturated thioamides: expeditious access to enantioenriched 1,5-benzothiazepines.
T. Ogawa, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2012, 51, 8551-8554.

anti-Selective direct catalytic asymmetric aldol reaction of thiolactams.
D. Sureshkumar, Y. Kawato, M. Iwata, N. Kumagai and M. Shibasaki.
Org. Lett. 2012, 14, 3108-3111.

Catalytic asymmetric synthesis of spirooxindoles via Mannich-type reaction of isothiocyanato oxindoles.
S. Kato, T. Yoshino, M. Shibasaki, M. Kanai and S. Matsunaga.
Angew. Chem. Int. Ed. 2012, 51, 7007-7010.

Catalytic asymmetric total synthesis of chimonanthine, folicanthine, and calycanthine through double Michael reaction of bisoxindole.
H. Mitsunuma, M. Shibasaki, M. Kanai and S. Matsunaga.
Angew. Chem. Int. Ed. 2012, 51, 5217-5221.

Concise enantioselective synthesis of duloxetine via direct catalytic asymmetric aldol reaction of thioamide.
Y. Suzuki, M. Iwata, R. Yazaki, N. Kumagai and M. Shibasaki.
J. Org. Chem. 2012, 77, 4496-4450.

Cooperative asymmetric catalysis using thioamides toward truly practical organic syntheses.
N. Kumagai and M. Shibasaki.
Isr. J. Chem. 2012, 57, 604-612.

Catalytic enantioselective desymmetrization of meso-glutaric anhydrides using a stable Ni₂-Schiff base catalyst.
P. Gopinath, T. Watanabe and M. Shibasaki.
Org. Lett. 2012, 14, 1358-1361.　

Catalytic asymmetric amination of oxindoles under dinuclear Ni₂-Schiff base catalysis.
S. Mouri, Z. H. Chen, S. Matsunaga and M. Shibasaki.
Heterocycles 2012, 84, 879-892.　

Direct catalytic asymmetric aldol reaction of α-sulfanyl lactones: efficient synthesis of SPT inhibitors.
S. Takechi, S. Yasuda, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2012, 51, 4218-4222.　

Asymmetric synthesis of dihydropyranones from ynones by sequential copper(I)-catalyzed direct aldol and silver(I)-catalyzed oxy-Michael reactions.
S. L. Shi, M. Kanai and M. Shibasaki.
Angew. Chem. Int. Ed. 2012, 51, 3932-3935.

Inhibitors of human 2,3-oxidosqualene cyclase (OSC) discovered by virtual screening.
T. Watanabe, I. Kurata, Y. Umezawa, Y. Takahashi and Y. Akamatsu.
Bioorg. Med. Chem. Lett. 2012, 22, 231-234.

Reversible heterochiral aggregation/dissociation of bis(2-hydroxyphenyl)diamides driven by UV/Vis irradiation.
A. Nojiri, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2012, 51, 2137-2141.

Catalytic asymmetric anti-selective nitroaldol reaction en route to zanamivir.
---selected as Hot Paper---
T. Nitabaru, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2012, 51, 1644-1647.

Intermediate as catalyst: catalytic asymmetric conjugate addition of nitroalkanes to
α,β-unsaturated thioamides.
T. Ogawa, S. Mouri, R. Yazaki, N. Kumagai and M. Shibasaki.
Org. Lett. 2012, 14, 110-113.

A simplified catalytic system for direct catalytic asymmetric aldol reaction of thioamides; application to an enantioselective synthesis of atorvastatin.
Y. Kawato, M. Iwata, R. Yazaki, N. Kumagai and M. Shibasaki.
Tetrahedron 2011, 67, 6539-6546.

Asymmetric synthesis of isothiazoles through Cu catalysis: direct catalytic asymmetric conjugate addition of allyl cyanide to α,β-unsaturated thioamides.
Y. Yanagida, R. Yazaki, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2011, 50, 7910-7914.

La/Ag heterobimetallic cooperative catalysis: a catalytic asymmetric Conia-ene reaction.
A. Matsuzawa, T. Mashiko, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2011, 50, 7616-7619.

Recent advances in direct catalytic asymmetric transformations under proton-transfer conditions.
N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2011, 50, 4760-4772.

Stereodivergent direct catalytic asymmetric Mannich-type reactions of α-isothiocyanato ester with ketimines.
G. Lu, T. Yoshino, H. Morimoto, S. Matsunaga and M. Shibasaki.
Angew. Chem. Int. Ed. 2011, 50, 4382-4385.

Recent development in synthetic strategies for oseltamivir phosphate.
M. Shibasaki, M. Kanai and K. Yamatsugu.
Isr. J. Chem. 2011, 51, 316-328.

Direct catalytic asymmetric intramolecular conjugate addition of thioamide to α,β-unsaturated esters.
Y. Suzuki, R. Yazaki, N. Kumagai and M. Shibasaki.
Chem. Eur. J. 2011, 17, 11998-12001.

Catalytic asymmetric hydroxylation of α-alkoxycarbonyl amides with a Pr(OⁱPr)₃/amide-based ligand catalyst.
S. Takechi, N. Kumagai and M. Shibasaki.
Tetrahedron Lett. 2011, 52, 2140-2143.

Catalytic asymmetric ring-opening of meso-aziridines with malonates under heterodinuclear rare earth metal Schiff base catalysis.
Y. J. Xu, L. Q. Lin, M. Kanai, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc. 2011, 133, 5791-5793.

Direct catalytic enantio- and diastereoselective aldol reaction of thioamides.
M. Iwata, R. Yazaki, I. H. Chen, D. Sureshkumar, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2011, 133, 5554-5560.

Cooperative activation of alkyne and thioamide functionalities; direct catalytic asymmetric conjugate addition of terminal alkynes to α,β-unsaturated thioamides.
R. Yazaki, N. Kumagai and M. Shibasaki.
Chem. Asian J. 2011, 6, 1778-1790.

Catalytic asymmetric amination of N-nonsubstituted α-alkoxycarbonyl amides: concise enantioselective synthesis of mycestericin F and G.
F. Berhal, S. Takechi, N. Kumagai and M. Shibasaki.
Chem. Eur. J. 2011, 17, 1915-1921.

Development of atom-economical catalytic asymmetric reactions under proton transfer conditions: construction of tetrasubstituted stereogenic centers and their application to therapeutics.
N. Kumagai.
Chem. Pharm. Bull. 2011, 59, 1-22.

Enantioselective synthesis of a GPR40 agonist AMG 837 via catalytic asymmetric conjugate addition of terminal alkyne to α,β-unsaturated thioamide.
R. Yazaki, N. Kumagai and M. Shibasaki.
Org. Lett. 2011, 13, 952-955.　

A heterobimetallic Ni/La-salan complex for catalytic asymmetric decarboxylative
1,4-addition of malonic acid half-thioester.
M. Furutachi, S. Mouri, S. Matsunaga and M. Shibasaki.
Chem. Asian J. 2010, 5, 2351-2354.

The synthesis of paleic acid, an antimicrobial agent effective against Mannheimia and
Pasteurella, and its structurally related derivatives.
T. Watanabe, I. Kurata, C. Hayashi, M. Igarashi, R. Sawa, Y. Takahashi and
Y. Akamatsu.
Bioorg. Med. Chem. Lett. 2010, 20, 5843-5846.

Copper(I)-secondary diamine complex-catalyzed enantioselective conjugate boration of
linear β,β-disubstituted enones.
I. H. Chen, M. Kanai and M. Shibasaki.
Org. Lett. 2010, 12, 4098-4101.

Catalytic asymmetric aza-Morita-Baylis-Hillman reaction of methyl acrylate: role of a
bifunctional La(OⁱPr)₃/linked-BINOL complex.
T. Yukawa, B. Seelig, Y. Xu, H. Morimoto, S. Matsunaga, A. Berkessel and M. Shibasaki.
J. Am. Chem. Soc. 2010, 132, 11988-11992.

Direct catalytic asymmetric conjugate addition of terminal alkynes to α,β-unsaturated
thioamides.
R. Yazaki, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2010, 132, 10275-10277.

Identification of modular chiral bisphosphines effective for Cu(I)-catalyzed asymmetric
allylation and propargylation of ketones.
S. L. Shi, L. W. Xu, K. Oisaki, M. Kanai and M. Shibasaki.
J. Am. Chem. Soc. 2010, 132, 6638-6639.

Solvent-dependent self-discrimination of bis(2-hydroxyphenyl)diamides.
A. Matsuzawa, A. Nojiri, N. Kumagai and M. Shibasaki.
Chemistry 2010, 16, 5036-5042.

Direct catalytic asymmetric addition of allyl cyanide to ketones via soft Lewis acid/hard
Brønsted base/hard Lewis base catalysis.
R. Yazaki, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2010, 132, 5522-5531.

Catalytic asymmetric nitro-Mannich reactions with a Yb/K heterobimetallic catalyst.
T. Nitabaru, N. Kumagai and M. Shibasaki.
Molecules 2010, 15, 1280-1290.

Heterobimetallic transition metal/rare earth metal bifunctional catalysis: a Cu/Sm/Schiff base complex for syn-selective catalytic asymmetric nitro-Mannich reaction.
S. Handa, V. Gnanadesikan, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc. 2010, 132, 4925-4934.

Catalytic asymmetric conjugate addition of α-cyanoketones for the construction of a
quaternary stereogenic center.
Y. Kawato, N. Takahashi, N. Kumagai and M. Shibasaki.
Org. Lett. 2010, 12, 1484-1487.

Direct catalytic asymmetric vinylogous Mannich-type and Michael reactions of an
α,β-unsaturated γ-butyrolactam under dinuclear nickel catalysis.
N. E. Shepherd, H. Tanabe, Y. Xu, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc. 2010, 132, 3666-3667.

Catalytic asymmetric 1,4-additions of β-keto esters to nitroalkenes promoted by a
bifunctional homobimetallic Co₂-Schiff base complex.
M. Furutachi, Z. Chen, S. Matsunaga and M. Shibasaki.
Molecules 2010, 15, 532-544.

Catalytic asymmetric total synthesis of ent-hyperforin.
Y. Shimizu, S. L. Shi, H. Usuda, M. Kanai and M. Shibasaki.
Angew. Chem. Int. Ed. 2010, 49, 1103-1106.

Catalytic asymmetric synthesis of 3-aminooxindoles: enantiofacial selectivity switch in
bimetallic vs monometallic Schiff base catalysis.
S. Mouri, Z. Chen, H. Mitsunuma, M. Furutachi, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc. 2010, 132, 1255-1257.

Direct catalytic asymmetric aldol reaction of thioamides: a concise asymmetric synthesis
of (R)-fluoxetine.
M. Iwata, R. Yazaki, M. Kumagai and M. Shibasaki.
Tetrahedron: Asymmetry. 2010, 21, 1688-1694.

syn-Selective catalytic asymmetric 1,4-addition of α-ketoanilides to nitroalkenes under
dinuclear nickel catalysis.
Y. Xu, S. Matsunaga and M. Shibasaki.
Org. Lett. 2010, 12, 3246-3249.

The first catalytic asymmetric total synthesis of ent-hyperforin.
Y. Shimizu, S. Shi, H. Usuda, M. Kanai and M. Shibasaki.
Tetrahedorn 2010, 66, 6569-6584.

Direct catalytic asymmetric aldol reactions of thioamides: toward a stereocontrolled
synthesis of 1,3-polyols.
M. Iwata, R. Yazaki, Y. Suzuki, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2009, 131, 18244-18245.

Construction of contiguous tetrasubstituted chiral carbon stereocenters via direct
catalytic asymmetric aldol reaction of α-isothiocyanato esters with ketones.
T. Yoshino, H. Morimoto, G. Lu, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc. 2009, 131, 17082.

Inventing and understanding catalytic, enantioselective reactions.
M. Shibasaki, N. Kumagai and T. Mashiko.
Curr. Opin. Drug Discov. Devel. 2009, 12, 862-875.

Managing highly coordinative substrates in asymmetric catalysis: a catalytic asymmetric amination with a lanthanum-based ternary catalyst.
T. Mashiko, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2009, 131, 14990-14999.

anti-Selective catalytic asymmetric nitroaldol reaction via a heterobimetallic heterogeneous catalyst.
T. Nitabaru, A. Nojiri, M. Kobayashi, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2009, 131, 13860-13869.

Recent progress in asymmetric bifunctional catalysis using multimetallic systems.
M. Shibasaki, M. Kanai, S. Matsunaga and N. Kumagai.
Accounts of Chemical Research 2009, 42, 1117-1127.

Catalytic asymmetric synthesis of α-alkylidene-β-hydroxy esters via dynamic kinetic
asymmetric transformation involving Ba-catalyzed direct aldol reaction.
A. Yamaguchi, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc. 2009, 131, 10842.

An alternative synthesis of Tamiflu (R): a synthetic challenge and the identification of a
ruthenium-catalyzed dihydroxylation route.
K. Yamatsugu, M. Kanai and M. Shibasaki.
Tetrahedron 2009, 65, 6017-6024.

Nucleophile generation via decarboxylation: asymmetric construction of contiguous
trisubstituted and quaternary stereocenters through a Cu(I)-catalyzed decarboxylative
Mannich-type reaction.
L. Yin, M. Kanai and M. Shibasaki.
J. Am. Chem. Soc. 2009, 131, 9610-9611.

A homodinuclear Mn(III)₂-Schiff base complex for catalytic asymmetric 1,4-additions of
oxindoles to nitroalkenes.
Y. Kato, M. Furutachi, Z. H. Chen, H. Mitsunuma, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc. 2009, 131, 9168.

Design and synthesis of immobilized Tamiflu analog on resin for affinity chromatography.
Y. Kimura, K. Yamatsugu, M. Kanai, N. Echigo, T. Kuzuhara and M. Shibasaki.
Tetrahedron Lett. 2009, 50, 3205-3208.

Mixed La-Li heterobimetallic complexes for tertiary nitroaldol resolution.
K. Hara, S. Y. Tosaki, V. Gnanadesikan, H. Morimoto, S. Harada, M. Sugita,
N. Yamagiwa, S.Matsunaga and M. Shibasaki.
Tetrahedron 2009, 65, 5030-5036.

A heterobimetallic Ga/Yb-Schiff base complex for catalytic asymmetric α-addition of
isocyanides to aldehydes.
H. Mihara, Y. J. Xu, N. E. Shepherd, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc. 2009, 131, 8384.

Catalytic asymmetric synthesis of nitrogen-containing gem-bisphosphonates using a
dinuclear Ni₂-Schiff base complex.
Y. Kato, Z. H. Chen, S. Matsunaga and M. Shibasaki.
Synlett 2009, 1635-1638.

Direct catalytic asymmetric Mannich-type reaction of thioamides.
Y. Suzuki, R. Yazaki, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2009, 48, 5026-5029.

Enantioselective synthesis of SM-130686 based on the development of asymmetric Cu(I)F catalysis to access 2-oxindoles containing a tetrasubstituted carbon.
D. Tomita, K. Yamatsugu, M. Kanai and M. Shibasaki.
J. Am. Chem. Soc. 2009, 131, 6946.

Catalytic asymmetric synthesis of chiral tertiary organoboronic esters through conjugate boration of β-substituted cyclic enones.
I. H. Chen, L. Yin, W. Itano, M. Kanai and M. Shibasaki.
J. Am. Chem. Soc. 2009, 131, 11664.

Sequential regulation of DOCK2 dynamics by two phospholipids during deutrophil
chemotaxis.
A. Nishikimi, H. Fukuhara, W. J. Su, T. Hongu, S. Takasuga, H. Mihara, Q. H. Cao,
F. Sanematsu, M. Kanai, H. Hasegawa, Y. Tanaka, M. Shibasaki, Y. Kanaho, T. Sasaki,
M. A. Frohman and Y. Fukui.
Science 2009, 324, 384-387.

Two methods for catalytic generation of reactive enolates promoted by a chiral poly Gd
complex: application to catalytic enantioselective protonation reactions.
M. Morita, L. Drouin, R. Motoki, Y. Kimura, I. Fujimori, M. Kanai and M. Shibasaki.
J. Am. Chem. Soc. 2009, 131, 3858.

Linking structural dynamics and functional diversity in asymmetric catalysis.
A. Nojiri, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2009, 131, 3779-3784.

Direct catalytic asymmetric addition of allyl cyanide to ketones.
R. Yazaki, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2009, 131, 3195-3197.

A stable homodinuclear biscobalt(III)-Schiff base complex for catalytic asymmetric
1,4-addition reactions of β-keto esters to alkynones.
Z. Chen, M. Furutachi, Y. Kato, S. Matsunaga and M. Shibasaki.
Angew. Chem. Int. Ed. 2009, 48, 2218-2220.

Direct catalytic asymmetric aldol reaction of β-keto esters with formaldehyde promoted by a dinuclear Ni₂-Schiff base complex.
S. Mouri, Z. H. Chen, S. Matsunaga and M. Shibasaki.
Chemical Communications 2009, 5138-5140.

Catalytic asymmetric synthesis of 2,2-disubstituted oxetanes from ketones by using a
one-pot sequential addition of sulfur ylide.
T. Sone, G. Lu, S. Matsunaga and M. Shibasaki.
Angew. Chem. Int. Ed. 2009, 48, 1677-1680.

Direct anti-selective catalytic asymmetric Mannich-type reactions of α-ketoanilides for
the synthesis of γ-amino amides and azetidine-2-amides.
Y. J. Xu, G. Lu, S. Matsunaga and M. Shibasaki.
Angew. Chem. Int. Ed. 2009, 48, 3353-3356.

A synthesis of Tamiflu by using a barium-catalyzed asymmetric Diels-Alder-type
Reaction.
K. Yamatsugu, L. Yin, S. Kamijo, Y. Kimura, M. Kanai and M. Shibasaki.
Angew. Chem. Int. Ed. 2009, 48, 1070-1076.

Asymmetric reductive Mannich reaction to ketimines catalyzed by a Cu(I) complex.
Y. Du, L. W. Xu, Y. Shimizu, K. Oisaki, M. Kanai and M. Shibasaki.
J. Am. Chem. Soc. 2008, 130, 16146-16147.

Cu(I)-catalyzed hetero-Diels-Alder reaction between Danishefsky-type siloxy dienes and
ketones.
I. H. Chen, K. Oisaki, M. Kanai and M. Shibasaki.
Org. Lett. 2008, 10, 5151-5154.

Direct catalytic asymmetric addition of allylic cyanides to ketoimines.
R. Yazaki, T. Nitabaru, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2008, 130, 14477.

Lewis base assisted Brønsted base catalysis: bidentate phosphine oxides as activators and modulators of Brønsted basic lanthanum-aryloxides.
H. Morimoto, T. Yoshino, T. Yukawa, G. Lu, S. Matsunaga and M. Shibasaki.
Angew. Chem. Int. Ed. 2008, 47, 9125-9129.

Catalytic conjugate addition of cyanide to enones: Cooperative catalysis of Ni(0) and
Gd(OTf)₃.
Y. Tanaka, M. Kanai and M. Shibasaki.
Synlett 2008, 2295-2298.

Direct catalytic asymmetric Mannich-type reaction of β-keto phosphonate using a dinuclear
Ni₂-Schiff base complex.
Z. Chen, K. Yakura, S. Matsunaga and M. Shibasaki.
Org. Lett. 2008, 10, 3239-3242.

Asymmetric synthesis of tertiary alcohols and α-tertiary amines via Cu-catalyzed C-C bond formation to ketones and ketimines.
M. Shibasaki and M. Kanai.
Chemical Reviews 2008, 108, 2853-2873.

An improved lanthanum catalyst system for asymmetric amination: toward a practical
asymmetric synthesis of AS-3201 (ranirestat).
T. Mashiko, N. Kumagai and M. Shibasaki.
Org. Lett. 2008, 10, 2725-2728.

Strategies for constructing diverse chiral environments in multimetallic bifunctional
asymmetric catalysis.
M. Shibasaki, S. Matsunaga and N. Kumagai.
Synlett 2008, 1583-1602.

Stereodivergent catalytic doubly diastereoselective nitroaldol reactions using
heterobimetalic complexes.
Y. Sohtome, Y. Kato, S. Handa, N. Aoyama, K. Nagawa, S. Matsunaga and
M. Shibasaki.
Org. Lett. 2008, 10, 2231-2234.

Direct catalytic asymmetric Mannich-type reactions of γ-butenolides: effectiveness of
Brønsted acid in chiral metal catalysis.
A. Yamaguchi, S. Matsunaga and M. Shibasaki.
Org. Lett. 2008, 10, 2319-2322.

A catalytic enantioselective conjugate addition of cyanide to enones.
Y. Tanaka, M. Kanai and M. Shibasaki.
J. Am. Chem. Soc. 2008, 130, 6072.

Asymmetric catalysis via dynamic substrate/ligand/rare earth metal conglomerate.
A. Nojiri, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2008, 130, 5630.

Sc³⁺-catalyzed aldol-type additions of N-benzoylcyclopropanecarboxamides via
iodide-mediated ring-opening: stereoselective synthesis of γ-lactams.
S. H. Wiedemann, H. Noda, S. Harada, S. Matsunaga and M. Shibasaki.
Org. Lett. 2008, 10, 1661-1664.

Catalytic asymmetric synthesis of 2,2-disubstituted terminal epoxides via
dimethyloxosulfonium methylide addition to ketones.
T. Sone, A. Yamaguchi, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc. 2008, 130, 10078.

Synthetic strategies for oseltamivir phosphate.
M. Shibasaki and M. Kanai.
Eur. J. Org. Chem. 2008, 1839-1850.

Oseltamivir enhances hippocampal network synchronization.
A. Usami, T. Sasaki, N. Satoh, T. Akiba, S. Yokoshima, T. Fukuyama, K. Yamatsugu,
M. Kanai, M. Shibasaki, N. Matsuki and Y. Ikegaya.
J. Pharm. Sci. 2008, 106, 659-662.

A bench-stable homodinuclear Ni₂-Schiff base complex for catalytic asymmetric synthesis of
α-tetrasubstituted anti-α,β-diamino acid surrogates.
Z. H. Chen, H. Morimoto, S. Matsunaga and M. Shibasaki.
J. Am. Chem. Soc. 2008, 130, 2170.

P-glycoprotein restricts the penetration of oseltamivir across the blood-brain barrier.
A. Ose, H. Kusuhara, K. Yamatsugu, M. Kanai, M. Shibasaki, T. Fujita,
A. Yamamoto and Y. Sugiyama.
Drug Metabolism and Disposition 2008, 36, 427-434.

A method for the synthesis of an oseltamivir PET tracer.
M. Morita, T. Sone, K. Yamatsugu, Y. Solitome, S. Matsunaga, M. Kanaia,
W. B. Yasuyoshi and M. Shibasaki.
Bioorganic & Medicinal Chemistry Letters. 2008, 18, 600-602.

Multimetallic bifunctional asymmetric catalysis based on proximity effect control.
S. Matsunaga and M. Shibasaki.
Bulletin of the Chemical Society of Japan. 2008, 81, 60-75.

A catalytic asymmetric anti-selective nitroaldol reaction with a neodymium-sodium
heterobimetallic complex.
T. Nitabaru, N. Kumagai and M. Shibasaki.
Tetrahedron Lett. 2008, 49, 272-276.

A heterobimetallic Pd/La/Schiff base complex for anti-selective catalytic asymmetric
nitroaldol reactions and applications to short syntheses of β-adrenoceptor agonists.
S. Handa, K. Nagawa, Y. Sohtome, S. Matsunaga and M. Shibasaki.
Angew. Chem. Int. Ed. 2008, 47, 3230-3233.

Catalytic asymmetric epoxidation of α,β-unsaturated phosphane oxides with a
Y(OⁱPr)₃/biphenyldiol complex.
K. Hara, S. Y. Park, N. Yamagiwa, S. Matsunaga and M. Shibasaki.
Chem. Asian J. 2008, 3, 1500-1504.

Chiral γ-amino amide synthesis by heterobimetallic lanthanum/lithium/pybox-catalyzed direct asymmetric Mannich-type reactions of α-keto anilides.
G. Lu, H. Morimoto, S. Matsunaga and M. Shibasaki.
Angew. Chem. Int. Ed. 2008, 47, 6847-6850.

Chiral-catalyst-based convergent synthesis of HIV protease inhibitor GRL-06579A.
H. Mihara, Y. Sohtome, S. Matsunaga and M. Shibasaki.
Chem. Asian J. 2008, 3, 359-366.

A Dy₃-catalyzed Mannich-type reactions of 1-methylcyclopropanecarboxylate-type donors for the stereoselective synthesis of pyrrolidines with quarternary stereocenteres.
H. Noda, S.H. Widemann, S. Matsunaga and M. Shibasaki.
Chem. Lett. 2008, 37, 1180-1181.

Catalytic enantioselective addition of terminal alkynes to aldehydes: preparation of
(S)-(-)-1, 3-diphenyl-2-propyn-1-ol and (S)-(-)-4-methyl-1-phenyl-2-pentyn-1, 4-diol.
R. Takita, S. Harada, T. Ohsima, S. Matsunaga and M. Shibasaki.
Org. Synth. 2008, 85, 118-130.

※前所属での業績も含む
*The papers published in previous lab are included.