Laboratory of Molecular Structure Analysis

Research Outline

At the Laboratory of Molecular Structure Analysis, we use analytical apparatus such as nuclear magnetic resonance (NMR), mass spectrometry (MS), and X-ray crystal structure analysis for the structural analysis of a wide range of biologically active substances found in assay systems and also derivatives of these substances and synthetic compounds.

Theme outline

1. Metabolome analysis of microbial secondary metabolites

Microbial secondary metabolites have diverse chemical structures and biological activities. On the other hand, the discovery of new bioactive substances has become very difficult because of the numerous types of materials that have been found by intensive screening over a long period of time. We have carried out the very small amount dereplication system and an effective search of new bioactive substance has been conducted by the targetnon target screening analysis using high resolution high accuracy apparatus of LTQ Orbitrap LC-MS.

Fig.1 JEOL ECZ600R
Fig.1 JEOL ECZ600R
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Fig.2 Bruker AVANCE III HD 400
Fig.2 Bruker AVANCE III HD 400
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Thermo Fig.3 Bruker AVANCE III 500
Fig.3 Bruker AVANCE III 500
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Fig.4 Thermo Fisher Scientific LTQ Orbitrap
Thermo Fisher Scientific LTQ Orbitrap
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Fig.5 Shimadzu AXIMA TOF2
Fig.5 Shimadzu AXIMA TOF2
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