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Title Authors Journal Year Vol Pages
A fluorogenic C4N4 probe for azide-based labelling. H. Noda, Y. Asada, M. Shibasaki, N. Kumagai Org. Biomol. Chem. 2018 in press
Direct catalytic asymmetric mannich-type reaction of an α-Cf3 amide to isatin imines.
H. Noda, J. -S. Yu, N. Kumagai, M. Shibasaki
Synlett. 2018 in press
7-Azaindoline auxiliary: a versatile attachment facilitating enantioselective­ C–C bond-forming catalysis.
N. Kumagai, M. Shibasaki
Synthesis 2018 in press doi: 10.1055/s-0037-1610412
Achiral trisubstituted thioureas as secondary ligands to Cu(I) catalysts: direct catalytic asymmetric addition of α-fluoronitriles to imines. P. V. Balaji, L. Brewitz, N. Kumagai and M. Shibasaki
Angew. Chem. Int. Ed. 2018 in press doi:10.1002/anie.201812673
Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with vacuole membrane protein. X.-M. Liu, A. Yamasaki, X.-M. Du, V. C. Coffman, Y. Ohsumi, H. Nakatogawa, J.-Q. Wu, N. N. Noda and L.-L. Du eLife
2018 7 e41237
Endosomal Rab cycles regulate Parkin-mediated mitophagy. K. Yamano, C. Wang, S. A. Sarraf, C. Münch, R. Kikuchi, N. N. Noda, Y. Hizukuri, M. T. Kanemaki, W. Harper, K. Tanaka, N. Matsuda and R. J. Youle eLife 2018 7 e31326
MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs K. Okamoto, T. Ohishi, M. Kuroiwa, S. Iemura, T. Natsume and H. Seimiya Oncotarget 2018 9 35844-35855
Systematic and stereoselective total synthesis of mannosylerythritol lipids and evaluation of their antibacterial activity.
J. Nashida, N. Nishi, Y. Takahashi, C. Hayashi, M. Igarashi, D. Takahashi and K. Toshima J. Org. Chem. 2018 83 7281-7289
Intervenolin suppresses gastric cancer cell growth through the induction of TSP‑1 secretion from fibroblast‑like stromal cells.
J. Yoshida, H. Abe,T. Watanabe and M. Kawada Oncol. Lett. 2018 2018 6777-6785
anti-Selective catalytic asymmetric nitroaldol reaction of α-keto esters; Intriguing solvent effect, flow reaction, and synthesis of APIs
T. Karasawa, R. Oriez, N. Kumagai and M. Shibasaki
J. Am. Chem. Soc. 2018 140 12290-12295
Exploiting β‐Amino acid enolates in direct catalytic diastereo‐ and enantioselective C‐C bond forming reactions. J.-S. Yu, H. Noda and M. Shibasaki
Chem. Eur. J. 2018 24 15796-15800
Instability of the 16S rRNA methyltransferase-encoding npmA gene: why have bacterial cells possessing npmA not spread despite their high and broad resistance to aminoglycosides?
Y. Ishizaki, Y. Shibuya, C. Hayashi, K. Inoue, T. Kirikae, T. Tada, T. Miyoshi-Akiyama and M. Igarashi
J. Antibiot. 2018 71 798-807
A new biomarker candidate for spinal muscular atrophy : Identification of a peripheral blood cell population capable of monitoring the level of survival motor neuron protein. N. Otsuki, R. Arakawa, K. Kaneko, R. Aoki, M. Arakawa and K. Saito
PLoS One 2018 13(8) e0201764
Podocalyxin is crucial for the growth of oral squamous cell carcinoma cell line HSC-2. S. Itai, S. Yamada, M. Kaneko, M. Sano, T. Nakamura, M. Yanaka, S. Handa, K. Hisamatsu, Y. Nakamura, Y. Furusawa, M. Fukui, T. Ohishi, M. Kawada, H. Harada and Y. Kato
Biochem Biophys Rep. 2018 15 93-96
Translation of Hepatitis A virus IRES is upregulated by a hepatic cell-specific factor. A. Sadahiro, A. Fukao, M. Kosaka, Y. Funakami, N. Takizawa, O. Takeuchi, K.E. Duncan and T. Fujiwara Front. Genet. 2018 doi: 10.3389/fgene.2018.00307
Beneficial effects of green tea catechins on neurodegenerative diseases. M. Pervin, K. Unno, T. Ohishi, H. Tanabe, N. Miyoshi and Y. Nakamura
Molecules 2018 23 1297
Anti-podocalyxin antibody exerts antitumor effects via antibody-dependent cellular cytotoxicity in mouse xenograft models of oral squamous cell carcinoma.
S. Itai, T. Ohishi, MK. Kaneko, S. Yamada, S. Abe, T. Nakamura, M. Yanaka, YW. Chang, SI. Ohba, Y. Nishioka, M. Kawada, H. Harada and Y. Kato Oncotarget 2018 9 22480-22497
Structure-activity relationship study of Leucinostatin A, a modulator of tumor-stroma interaction. H. Abe, M. Kawada, C. Sakashita, T. Watanabe and M. Shibasaki Tetrahedoron 2018 74 5129-5137
Direct catalytic asymmetric 1,6-conjugate addition of amides to p-quinone methides. Z. Sun, B. Sun, N. Kumagai and M. Shibasaki Org. Lett. 2018 20 3070-3073
Direct enolization chemistry of 7-azaindoline amides: A case study of bis(tetrahydrophosphole)-type ligands. Z. Li, H. Noda, N. Kumagai and M. Shibasaki
Tetrahedron 2018 74 3301-3305
Direct catalytic asymmetric aldol reaction of α-vinyl acetamide. T. Takeuchi, N. Kumagai and M. Shibasaki
J. Org. Chem.
2018 83 5851-5858
Monotherapy with a novel intervenolin derivative, AS-1934, is an effective treatment for Helicobacter pylori infection. T. Ohishi, T. Masuda, H. Abe, C. Hayashi, H. Adachi, S. Ohba, M. Igarashi, T. Watanabe, H. Mimuro, E. Amalia, DK. Inaoka, K. Mochizuki, K. Kita, M. Shibasaki and M. Kawada Helicobacter 2018 23 e12470
Anti-influenza virus activity of a salcomine derivative mediated by inhibition of viral RNA synthesis. N. Takizawa, T. Kimura, T. Watanabe and M. Shibasaki
Arch. Virol. 2018 163 1607-1614
Quadoctomycin, a 48-membered macrolide antibiotic from Streptomyces sp.MM168-141F8. R. Sawa, Y. Kubota, M. Umekita, M. Hatano, C. Hayashi, M. Igarashi.
J Antibiot. 2018 71 91-96
Current landscape and future prospects of antiviral drugs derived from microbial products. N. Takizawa and M. Yamasaki J. Antibiot. 2018 71 45-52
A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2. M. Iijima, Yuji Kubota, R. Sawa, Yumiko Kubota, M. Hatano, M. Igarashi, M. Kawada, I. Momose, M. Takekawa and M. Shibasaki J. Antibiot. 2018 71 135-138
Catalytic asymmetric synthesis of α-trifluoromethylated carbinols: A case study of tertiary propargylic alcohols. H. Noda, N. Kumagai and M.Shibasaki
Asian J. Org. Chem. 2018 7 599-612
Dihydroorotate dehydrogenase as a target for the development of novel Helicobacter pylori-specific antimicrobials.
T. Ohishi, DK. Inaoka, K. Kita and M. Kawada Chem. Pharm. Bull. 2018 66 239-242
Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology. H. Adachi, K. Nakae, S. Sakamoto, C. Nosaka, S. Atsumi, M. Shibuya, N. Higashi, M. Nakajima, T. Irimura and Y. Nishimura
J. Antibiot. 2018 71 60-71
Conquering amide planarity: structural distortion and its hidden reactivity.
S. Adachi, N. Kumagai and M.Shibasaki Tetrahedron Lett. 2018 59 1147-1158
Novel approaches for identification of anti-tumor drugs and new bioactive compounds. M. Kawada, S. Atsumi, S. Wada and S. Sakamoto
J. Antibiot. 2018 71 39-44
Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp. ML1-hF4. H. Hashizume, K. Iijima, K. Yamashita, T. Kimura, S. Wada, R. Sawa and M. Igarashi J.Antibiot. 2018 71 129-134
Catalytic oligopeptide synthesis. Z. Liu, H. Noda, M. Shibasaki and N. Kumagai
Org. Lett. 2018 20 612-615
Direct catalytic asymmetric mannich-type reaction en route to α-hydroxy-β-amino acid derivatives. B. Sun, R. Pluta, N. Kumagai and M. Shibasaki
Org. Lett. 2018 20 526-529
Heterogeneous heterobimetallic catalysis enabling expeditious access to CF3 containing vic-amino alcohols. T. Karasawa, N. Kumagai and M. Shibasaki Org. Lett. 2018 20 308-311
Direct catalytic asymmetric aldol reaction of thioamide with an α-vinyl appendage. J. Cui, A. Ohtsuki, T. Watanabe, N. Kumagai and M. Shibasaki Chem. Eur. J. 2018 24 2598–2601
Atg7 activates an autophagy-essential ubiquitin-like protein Atg8 through multi-step recognition. M. Yamaguchi, K. Satoo, H. Suzuki, Y. Fujioka, Y. Ohsumi, F. Inagaki and N. N. Noda,
J. Mol. Biol. 2018 430 249-257
Biophysical characterization of Atg11, a scaffold protein essential for selective autophagy in yeast. H. Suzuki, H and N. N. Noda FEBS Open Bio. 2018 8 110-116
Autophagy-regulating protease Atg4: structure, function, regulation and inhibition. T. Maruyama and N. N. Noda J. Antibiot. 2018 71 72-78
Quaternary β2,2 -amino acids: Catalytic asymmetric synthesis and incorporation into peptides via Fmoc-SPPS. J.-S. Yu, H. Noda and M. Shibasaki
Angew. Chem. Int. Ed. 2018 57 818-822
Thieme chemistry journals awardees – Where are they now?
Bis(2-pyridyl)amides as readily cleavable amides under catalytic, neutral, and room-temperature conditions.
S. Adachi, N. Kumagai and M. Shibasaki Synlett 2018 29 301-305
Synthetic studies of viridiofungins, broad-spectrum antifungal agents and serine palmitoyl transferase inhibitors. N. Kumagai and M. Shibasaki J. Antibiot. 2018 71 53-59
In vivo efficacy of β-lactam/tripropeptin C in a mouse septicemia model and the mechanism of reverse β-lactam resistance in methicillin-resistant Staphylococcus aureus mediated by tripropeptin C. H. Hashizume1, Y. Takahashi, T. Masuda, S. Ohba, T. Ohishi, M. Kawada and M. Igarashi J Antibiot. 2018 71 79-85