Substances discovered by the MCRF and launched

Substance (Brand name) Use Discovered Marketed
1. Kanamycin Antibacterial chemotherapeutic drug 1957 1958
2. Bekanamycin
(Kanendomycin)
Antibacterial chemotherapeutic drug 1957 1969
3. Bleomycin
(Bleo)
Anticancer chemotherapeutic drug 1965 1969
4. Kasugamycin
(Kasumin)
Agrochemical for rice blast disease 1965 1970
5. Josamycin Antibacterial chemotherapeutic drug 1967 1970
6. Dibekacin
(Panimycin)
Antibacterial chemotherapeutic drug 1971 1975
7. Peplomycin
(Pepleo)
Anticancer chemotherapeutic drug 1977 1981
8. Aclarubicin
(Aclacinon)
Anticancer chemotherapeutic drug 1975 1982
9. Ubenimex
(Bestatin)
Anticancer chemotherapeutic drug 1976 1987
10. Prarubicin
(Pinorubin, Therarubicin)
Anticancer chemotherapeutic drug 1979 1988
11. Tylvalosin
(Aivlosin)
Antibacterial veterinary drug 1979 1989
12. Arbekacin
(Habekacin)
Antibacterial chemotherapeutic drug 1973 1990
13. Gusperimus
(Spanidin)
Immunosuppressive agent 1982 1994
14. Tildipirosin
(Zuprevo)
Antibacterial veterinary drug 2000 2011

Commercially available enzyme inhibitors used as reagents

Substance Enzyme inhibitor Discovered in
1. Leupeptin Serine/Cysteine proteinase 1969
2. Pepstatin Aspartic proteinase 1970
3. Chymostatin Serine/Cysteine proteinase 1970
4. Antipain Serine/Cysteine proteinase 1972
5. Phosphoramidon Metalloproteinase 1973
6. Elastatinal Serine proteinase 1973
7. Amastatin Aminopeptidase 1978
8. Ebelacton Esterase, Lipase, Aminopeptidase 1980
9. Arphamenines Aminopeptidase 1983
10. Diprotin A Dipeptidylaminopeptidase 1984
11. Actinonin Aminopeptidase 1985
12. Foroxymithine Dipeptidylaminopeptidase 1985
13. Leuhistin Aminopeptidase 1990
14. Cytostatin Protein phosphatase 2A 1994
15. Heliquinomycin DNA helicase 1996
16. Rubratoxin A Protein phosphatase 2A 2010 (Activity)
17. Heparastatin (SF4) Heparanase 1994