化合物一覧

Coformycin

Coformycin_1

Producing organism:

Nocardia interforma

Activity:

Inhibitor of adenosine deaminase

Clinical use:

-

Class no:

8 Reference(s)

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Title Author Journal Year Volume Page
Mode of inhibition of coformycin on adenosine deaminase. T. Sawa; Y. Fukagawa; I. Homma; T. Takeuchi; H. Umezawa J. Antibiotics 1967 20 227-231
Synthesis of coformycin. M. Ohno; N. Yagisawa; S. Shibahara; S. Kondo; K. Maeda; H. Umezawa J. Am. Chem. Soc. 1974 96 4326
Structure of coformycin, an unusual nucleoside of microbial origin. M. Ohno; N. Yagisawa; S. Kondo; K. Maeda; H. Umezawa; H. Nakamura J. Am. Chem. Soc. 1974 96 4327-4328
The crystal and molecular structure of coformycin. H. Nakamura; G. Koyama; H. Umezawa; Y. Iitaka Acta Crystallographica 1976 B32 1206
Synthesis of isocoformycin, an adenosine deaminase inhibitor of synthetic origin. M. Shimazaki; S. Kondo; K. Maeda; M. Ohno; H. Umezawa J. Antibiotics 1979 32 537-538
Studies on inhibition of adenosine deaminase by isocoformycin in vitro and in vivo. M. Shimazaki; Y.Kumada; T. Takeuchi; H. Umezawa; K. Watanabe J. Antibiotics 1979 32 654-658
Effects of a new adenosine deaminase inhibitor, isocoformycin, on toxicity, antitumor activity and tissue distribution of formycin A and 9-β-D-arabinofuranosyladenine. T. Hidaka; K. katayama; K. Yamashita; T. Yamashita; K. Watanabe; M. Shimazaki; M. Ohno; T. Takeuchi; H. Umezawa J. Antibiotics 1980 33 303-309