化合物一覧

Aclacinomycin

Aclacinomycin_1 Aclacinomycin_2 Aclacinomycin_3

Producing organism:

Streptomyces galilaeus

Activity:

Antitumor

Clinical use:

Antineoplastic

Class no:

15 Reference(s)

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Title Author Journal Year Volume Page
New antitumor antibiotics, aclacinomycins A and B. T. Oki; Y. Matsuzawa; A. Yoshimoto; K. Numata; I. Kitamura; S. Hori; A. Takamatsu; H. Umezawa; M. Ishizuka; H. Naganawa; H. Suda; M. Hamada; T. Takeuchi J. Antibiotics 1975 28 830-834
Antitumor activity of new anthracycline antibiotics, aclacinomycin-A and its analogs, and their toxicity. S. Hori; M. Shirai; S. Harano; T. Oki; T. Inui; S. Tsukagoshi; M. Ishizuka; T. Takeuchi; H. Umezawa Gann 1977 68 685-690
Enzymatic conversion of aclacinomycin A to Y by a specific oxidoreductase in Streptomyces. A. Yoshimoto; T. Ogasawara; I. Kitamura; T. Oki; T. Inui; T. Takeuchi; H. Umezawa J. Antibiotics 1979 32 472-481
Mechanism of action of aclacinomycin A. I. The effect on macromolecular syntheses. H. Yamaki; H. Suzuki; T. Nishimura; N. Tanaka J. Antibiotics 1978 31 1149-1154
Antitumor anthracycline antibiotics, aclacinomycin A and analogues. II. Structural determination. T. Oki; I. Kitamura; Y. Matsuzawa; N. Shibamoto; T. Ogasawara; A. Yoshimoto; T. Inui; H. Naganawa; T. Takeuchi; H. Umezawa J. Antibiotics 1979 32 801-819
Reduction of cinerulose in aclacinomycin-A by soluble and microsomal cinerulose reductases. T. Komiyama; T. Oki; T. Inui; T. Takeuchi; H. Umezawa Gann 1979 70 395-401
Antitumor anthracycline antibiotics, aclacinomycin A and analogues. I. Taxonomy, production, isolation and physicochemical properties. T. Oki; I. Kitamura; A. Yoshimoto; Y. Matsuzawa; N. Shibamoto; T. Oogasawara; T. Inui; A. Takamatsu; T. Takeuchi; T. Masuda; M. Hamada; H. Suda; M. Ishizuka; T. Sawa; H. Umezawa J. Antibiotics 1979 32 791-800
Biosynthesis of anthracycline antibiotics by Streptomyces galilaeus. I. Glycosidation of various anthracyclinones by an aclacinomycin-negative mutant and biosynthesis of aclacinomycins from aklavinone. T. Oki; A. Yoshimoto; Y. Matsuzawa; T. Takeuchi; H. Umezawa J. Antibiotics 1980 33 1331-1340
Current status of Japanese studies with the new anthracycline antibiotic aclacinomycin A. T. Oki; T. Takeuchi; S. Oka; H. Umezawa Recent Results in Cancer Research 1980 74 207-216
Enhancement of immune responses and possible inhibition of suppressor cells by aclacinomycin A. M. Ishizuka; T. Takeuchi; T. Masuda; S. Fukasawa; H. Umezawa J. Antibiotics 1981 34 331-340
New anthracycline antibiotic aclacinomycin A: Experimental studies and correlations with clinical trials. T. Oki; T. Takeuchi; S. Oka; H. Umezawa Recent Results in Cancer Research 1981 76 21-39
Experimental studies of new anthracyclines: Aclacinomycin, THP-adriamycin and ditrisarubicins. K. Umezawa; S. Kunimoto; T. Takeuchi Biomedicine & Pharmacotherapy 1987 41 206-213
Anthracycline antibiotic 2-hydroxyaclacinomycins. 1. 2-hydroxyacclacinomycin-producing recombinant obtianed from aclacinomycin-blocked mutants of Streptomyces galilaeus by a technique of protoplast fusion. A. Yoshimoto; O. Johdo; T. Ishikura; T. Takeuchi Jap. J. Antibiotics 1991 44 269-276
Microbial glycosidation of some anthracycline antibiotics by an antibiotic-negatie mutant of aclarubicin producer. O. Johdo; H. Tone; R. Okamoto; A. Yoshimoto; H. Naganawa; T. Sawa; T. Takeuchi J. Antibiotics 1993 46 1219-1231
New betaclamycin and aclarubicin analogs obtained by prolonged microbial conversion with an aclarubicin-negative mutant. O. Johdo; T. Yoshioka; H.Naganawa; T. Takeuchi; A. Yoshimoto J. Antibiotics 1996 49 669-675