化合物一覧

Arbekacin

Arbekacin_1

Producing organism:

-

Activity:

-

Clinical use:

-

Class no:

55 Reference(s)

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Title Author Journal Year Volume Page
Studies on inactivation of kanamycin and resistances of E. coli. M. Okanishi; S. Kondo; Y. Suzuki; S. Okamoto; H. Umezawa J. Antibiotics 1967 20 132-135
Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli. H. Umezawa; M. Okanishi; R. Utahara; K. Maeda; S. Kondo J. Antibiotics 1967 20 136-141
Phosphorylative inactivation of aminoglycosidic antibiotics by Escherichia coli carrying R factor. H. Umezawa; M. Okanishi; S. Kondo; K. Maeda; R. Utahara; S. Mitsuhashi Science 1967 157 1559-1561
Miscoding activities of biologically inactivated kanamycins. M. Hori; H. Umezawa J. Antibiotics 1967 20 386-387
Inactivation of kanamycin by E. coli carrying R factor and structures of the inactivated forms. H. Umezawa; M. Okanishi; S. Kondo 5th International Congress of Chemotherapy, Vienna 1967
Isolation of kanamycin and paromamine inactivated by E. coli carrying R factor. S. Kondo; M. Okanishi; R. Utahara; K. Maeda; H. Umezawa J. Antibiotics 1968 21 22-29
Progess in the fundamental studies on kanamycin. (Japanese) H. Umezawa Nippon Ishikai Zasshi 1967 58 1329-1341
The crystal structure of kanamycin. G. Koyama Tetrahedron Letters 1968 1875-1879
Progress of fundamental studies on kanamycin. I. The structure and the biosynthesis; II. Structure-activity relationship and mechanism of the resistance. H. Umezawa Asian Medical Journal 1968 11 69-77
Inactivation of kanamycin, neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginosa. O. Doi; M. Ogura; N. Tanaka; H. Umezawa Appl. Environ. Microbiol. 1968 1276-1281
Inactivation and phosphorylation of kanamycin by drug-resistant Staphylococcus aureus. O. Doi; M. Miyamoto; N. Tanaka; H. Umezawa Appl. Microbiology 1968 16 1282-1284
Phosphorylation and inactivation of kanamycin by Pseudomonas aeruginosa. H. Umezawa; O. Doi; M. Ogura; S. Kondo; N. Tanaka J. Antibiotics 1968 21 154-155
Studies on the biosynthesis of kanamycins. I. Incorporation of 14C-glucose or 14C-glucosamine into kanamycins and kanamycin-related compounds. M. Kojima; Y. Yamada; H. Umezawa Agric. Biol. Chem. 1968 32 467-473
Studies on the biosynthesis of kanamycins. II. Incorporation of the radioactive degradation products of kanamycin A or related metabolites into kanamycin A. M. Kojima; Y. Yamada; H. Umezawa Agric. Biol. Chem. 1969 33 1181-1185
Purification and properties of kanamycin phosphorylating enzyme from Pseudomonas aeruginosa. O. Doi; S. Kondo; N. Tanaka; H. Umezawa J. Antibiotics 1969 22 273-282
Effects of kanamycin on protein synthesis: Inhibition of peptide chains. J. Suzuki; T. Kunimoto; M. Hori J. Antibiotics 1970 23 99-101
Studies on kanamycin related compounds produced during fermentation by mutants of Streptomyces kanamyceticus. M. Murase; T. Ito; S. Fukatsu; H. Umezawa Progress in Antimicrobial and Anticancer Chemotherapy 1970 11 1098
Adenylyl dideoxykanamyci B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor. M. Yagisawa; H. Naganawa; S. Kondo; M. Hamada; T. Takeuchi; H. Umezawa J. Antibiotics 1971 24 911-912
Kanamycin derivatives effective against resistant organisms. H. Umezawa; T. Takeuchi; T. Tsuchiya; S. Umezawa Proceedings of the VIIth International Congress of Chemotherapy, Prague 1971
Kanamycin phosphotransferase I: Mechanism of cross resistance between kanamycin and lividomycin. H. Umezawa; H. Yamamoto; M. Yagisawa; S. Kondo; T. Takeuchi; Y. A. Chabbert J. Antibiotics 1973 26 407-411
Syntheses of isoseryl derivatives of kanamycins and their antibacterial activities. S. Kondo; K. Iinuma; M. Hamada; K. Maeda; H. Umezawa J. Antibiotics 1974 27 90-93
Elimination of the ability of a kanamycin-producing strain to biosynthesize deoxystreptamine moiety by acriflavine. K. Hotta; Y. Okami; H. Umezawa J. Antibiotics 1977 30 1146-1149
Syntheses and properties of kanamycin C derivatives active against resistant bacteria. S. Kondo; T. Miyasaka; K. Yoshida; K. Iinuma; H. Umezawa J. Antibiotics 1977 30 1150-1152
Discoveries of kanamycin and bleomycin -Chemistry of Antibiotics- (Japanese) H. Umezawa Kagaku Kyoiku 1978 26 434-442
Syntheses and properties of the 6"-deoxy or 4",6"-dideoxy derivatives of the kanamycin antibiotics. T. Miyasaka; D. Ikeda; S. Kondo; H. Umezawa J. Antibiotics 1980 33 527-532
Stereospecific transformation of D-sugar to L-sugar in complex aminoglycoside. Synthesis of a kanamycin B analog having 2,6-diamino-2,4,6-trideoxy-L-arabino-hexopyranose. Y. Nishimura; H. Umezawa; S. Umezawa Tetrahedron Letters 1981 22 77-80
Combimicins, new kanamycin derivatives bioconverted by some Micromonosporas. Y. Oka; H. Ishida; M. Morioka; Y. Numasaki; T. Yamafuji; T. Osono; H. Umezawa J. Antibiotics 1981 34 777-781
Resistance mechanisms of kanamycin-, neomycin-, and streptomycin-producing streptomycetes to aminoglycoside antibiotics. K. Hotta; H. Yamamoto; Y. Okami; H. Umezawa J. Antibiotics 1981 34 1175-1182
Regiospecific introduction of a branched-chain to kanamycin B and stereospecific transformation of the 2,6-diamino-2,6-dideoxy-D-glucopyranosyl moiety into 2,6-diamino-2,6-tetradeoxy-3-C-methyl-L-arabino or lyxo-hexopyranosyl, or 2-amino-2,3,4,6-tetradeoxy-5- C-methyl-L-threohexopyranosyl. Y. Nishimura; S. Umezawa Tetrahedron Letters 1982 23 81-84
A novel deaminative cyclization of aminoglycoside. Synthesis of a kanamycin B variant having 2-oxa-5-azabicyclo[2,2,2]oct-1,5-diene ring. Y. Nishimura; S. Umezawa Tetrahedron Letters 1982 23 85-86
A predominant role of amino groups in the antibacterial action of aminoglycosides: Synthesis of hexa- and heptadeoxykanamycin derivatives. H. Umezawa; H. Iwasawa; D. Ikeda; S. Kondo J. Antibiotics 1983 36 1087-1091
Synthesis of 1-N-(2-aminoethanesulfonyl)kanamycins and related aminoglycoside antibiotics. E. Akita; Y. Horiuchi; T. Miyazawa; H. Umezawa J. Antibiotics 1983 36 745-748