化合物一覧
Hydroxypepstatin
Producing organism:
Streptomyces testaceusStreptomyces parvisporogen strain MD494-A1
Activity:
Pepsin (aspartic proteinase) inhibitor
Clinical use:
-
Class no:
19 Reference(s)
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| Title | Author | Journal | Year | Volume | Page |
|---|---|---|---|---|---|
| The structure of pepstatin. | H. Morishima; T. Takita; T. Aoyagi; T. Takeuchi; H. Umezawa | J. Antibiotics | 1970 | 23 | 263-265 |
| Pepstatin, a new pepsin inhibitor produced by Actinomycetes. | H. Umezawa; T. Aoyagi; H. Morishima; M. Matsuzaki; M. Hamada; T. Takeuchi | J. Antibiotics | 1970 | 23 | 259-262 |
| Effect of pepstatin on acid proteases. | T. Aoyagi; S. Kunimoto; H. Morishima; T. Takeuchi; H. Umezawa | J. Antibiotics | 1971 | 24 | 687-694 |
| Mechansim of inhibition of pepsin by pepstatin. | S. Kunimoto; T. Aoyagi; H. Morishima; T. Takeuchi; H. Umezawa | J. Antibiotics | 1972 | 25 | 251-255 |
| New pepstatins, pepstatins B and C and pepstanone A, produced by Streptomyces. | T. Miyano; M. Tomiyasu; H. Iizuka; S. Tomisaka; T. Takita; T. Aoyagi; H. Umezawa | J. Antibiotics | 1972 | 25 | 489-491 |
| The chemical synthesis of pepstatin A. | H. Morishima; T. Takita; H. Umezawa | J. Antibiotics | 1972 | 25 | 551-552 |
| Biological activity of pepstatins, pepstanone A and partial peptides on pepsin, cathepsin D and renin. | T. Aoyagi; H. Morishima; R. Nishizawa; S. Kunimoto; T. Takeuchi; H. Umezawa; H. Ikezawa | J. Antibiotics | 1972 | 25 | 689-694 |
| X-ray structure determination of 4-amino-3-hydroxy-6-methylheptanoic acid, an amine component of pepstatin. | H. Nakamura; H.Morishima; T. Takita; H. Umezawa; Y. Iitaka | J. Antibiotics | 1973 | 26 | 255-256 |
| Synthesis of 4-amino-3-hydroxy-6-methylheptanoic acid, an amine component of pepstatin. | H. Morishima; T. Takita; H. Umezawa | J. Antibiotics | 1973 | 26 | 115-116 |
| Inhibitory activity of pepstatin against acid protease and an estimation method of acid protease in gastric juice. (Japanese) | T. Aoyagi; S. Kunimoto; T. Takeuchi; H. Umezawa | Jap. J. Antibiotics | 1973 | 26 | 109-114 |
| New pepstatins, pepstatins BU, PR and AC produced by Streptomyces. | T. Aoyagi; Y. Yagisawa; M. Kumagai; M. Hamada; H. Morishima; T. Takeuchi; H. Umezawa | J. Antibiotics | 1973 | 26 | 539-541 |
| Hydroxypepstatin, a new pepstatin produced by Streptomyces. | H. Umezawa; T. Miyano; T. Murakami; T. Takita; T. Aoyagi; T. Takeuchi; H. Naganawa; H. Morishima | J. Antibiotics | 1973 | 26 | 615-617 |
| Fundamental studies on Pepstatin (Nos.1-4). | Matsuzaki et al. | Yakubutu Ryoho | |||
| Biosynthetic studies on pepstatin. Biosynthesis of (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid moiety. | H. Morishima; T. Sawa; T. Takita; T. Aoyagi; T. Takeuchi; H. Umezawa | J. Antibiotics | 1974 | 27 | 267-273 |
| Mechanism of inhibition of pepsin by pepstatin. II. | S. Kunimoto; T. Aoyagi; R. Nishizawa; T. Komai; T. Takeuchi; H. Umezawa | J. Antibiotics | 1974 | 27 | 413-418 |
| Enzymatic degradation of pepstatin A to a new tetrapeptide. | H. Tone; N. Shibamoto; Y. Matsushita; T. Inui; A. Takamatsu; T. aoyagi; T. Takeuchi; H. Umezawa | J. Antibiotics | 1975 | 28 | 1009-1011 |
| Purification and properties of pepstatin hydrolase from Bacillus sphaericus. | H. Tone; Y. Matsushita; Y. Yagi; A. Takamatsu; T. Aoyagi; T. Takeuchi; H. Umezawa | J. Antibiotics | 1975 | 28 | 1012-1015 |
| N-Acylated derivatives of a peptide obtianed by enzymatic degradation of pepstatins. | Y. Matsushita; H. Tone; S. Hori; Y. Yagi; A. Takamatsu; H. Morishima; T. Aoyagi; T. Takeuchi; H.Umezawa | J. Antibiotics | 1975 | 28 | 1016-1018 |
| The effects of lactoyl-pepstatin and the pspsin inhibitor peptide on pig cathepsin D. | J. Kay; E.-G. Afting; T. Aoyagi; B-M. Dunn | Biochemical Journal | 1982 | 203 | 795-797 |