Compounds

Dephostatin

Dephostatin_1

Producing organism:

Streptomyces sp. MJ742-NF5

Activity:

Tyrosine phosphatase inhibitorAntibacterial,Cytotoxic

Clinical use:

-

Class no:

5 Reference(s)

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Title	Author	Journal	Year	Volume	Page
Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy, isolation, and characterization.	M. Imoto; H. Kakeya; T. Sawa; C. Hayashi; M. Hamada; T. Takeuchi; K. Umezawa	J. Antibiotics	1993	46	1342-1346
Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination.	H. Kakeuya; M. Imoto; Y. Takahashi; H. Naganawa; T. Takeuchi; K. Umezawa	J. Antibiotics	1993	46	1716-1719
Total synthesis of dephostatin, a novel protein tyrosine phosphatase inhibitor.	T. Watanabe; T. Takeuchi; M. Otsuka; K. Umezawa	J. Chem. Soc., Chem. Commun.	1994	4	437-438
Synthesis and protein tyrosine phosphatase inhibitory activity of dephostatin analogs.	T. Watanabe; T. Takeuchi; M. Otsuka; S. Tanaka; K. Umezawa	J. Antibiotics	1995	48	1460-1466
Enhancement or induction of neurite formation by a protein tyrosine phosphatase inhibitor, 3,4-dephostatin, in growth factor-treated PC12h cells.	S. Fujiwara; T. Watanabe; T. Nagatsu; J. Gohda; M. Imoto; K. Umezawa	Biochem. Biophys. Res. Commun.	1997	238	213-217