Compounds
15-Deoxyspergualin
Producing organism:
Bacillus laterosporus
Activity:
AntitumorImmunomodulator
Clinical use:
Gusperimus (15-deoxyspergualin) Immunosuppressor
Class no:
64 Reference(s)
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| Title | Author | Journal | Year | Volume | Page |
|---|---|---|---|---|---|
| A new antitumor antibiotic, spergualin: Isolation and antitumor activity. | T. Takeuchi; H. Iinuma; S. Kunimoto; T. Masuda; M. Ishizuka; M. Takeuchi; M. Hamada; H. Naganawa; S. Kondo; H. Umezawa | J. Antibiotics | 1981 | 34 | 1619-1621 |
| Structure of an antitumor antibiotic, spergualin. | H. Umezawa; S. Kondo; H. Iinuma; S. Kunimoto; Y. Ikeda; H. Iwasawa; D. Ikeda; T. Takeuchi | J. Antibiotics | 1981 | 34 | 1622-1624 |
| The total synthesis of spergualin, an antitumor antibiotic. | S. Kondo; H. Iwasawa; D. Ikeda; Y. Umeda; Y. Ikeda; H. Iinuma; H. Umezawa | J. Antibiotics | 1981 | 34 | 1625-1627 |
| A new antitumor antibiotic spergualin. | S. Kondo; T. Takeuchi; H. Umezawa | Trends in Antibiotic Research | 1982 | 146-153 | |
| Synthesis of (-)-15-deoxyspergualin and (-)-spergualin-15-phosphate. | H. Iwasawa; S. Kondo; D. Ikeda; T. Takeuchi; H. Umezawa | J. Antibiotics | 1982 | 35 | 1665-1669 |
| Spergualin: a novel antitumor antibiotic produced by Bacillus laterosporus. (Japanese) | T. Takeuchi | Gan to Kagaku Ryoho | 1984 | 11 | 2633-2639 |
| Suppression of tissue graft rejection by spergualin. | H. Umezawa; M. Ishizuka; T. Takeuchi; F. Abe; K. Nemoto; K. Shibuya; T. Nakamura | J. Antibiotics | 1985 | 38 | 283-284 |
| Cytotoxicity of spergualin and amine oxidase activity in medium. | S. Kunimoto; K. Miura; H. Iinuma; T. Takeuchi; H. Umezawa | J. Antibiotics | 1985 | 38 | 899-903 |
| Synthesis and antitumor activity of spergualin analogues. I. Chemical modification of 7-guanidino-3-hydroxyacyl moiety. | Y. Umeda; M. Moriguchi; H. Kuroda; T. Nakamura; H. Iinuma; T. Takeuchi; H. Umezawa | J. Antibiotics | 1985 | 38 | 886-898 |
| Antitumor activity of spergualin, a novel antitumor antibiotic. | K. Nishikawa; C. Shibasaki; K. Takahashi; T. Nakamura; T. Takeuchi; H. Umezawa | J. Antibiotics | 1986 | 39 | 1461-1466 |
| Anti-leukemic activity of 15-deoxyspergualin against N-butyl-N-nitrosourea-induced autochthonous rat leukemia. | J. Ito; T. Yamashita; K. Takahashi; H. Horinishi; T. Nakamura; T. Takeuchi; H. Umezawa | J. Antibiotics | 1986 | 39 | 1488-1490 |
| Induction of antitumor resistance to mouse leukemia L1210 by spergualins. | M. Ishizuka; T. Masuda; S. Mizutani; M. Osono; H. Kumagai; T. Takeuchi; H. Umezawa | J. Antibiotics | 1986 | 39 | 1736-1743 |
| Spergualin, a new antitumor antibiotic. (Japanese) | T. Takeuchi | Gan to Kagaku Ryoho | 1987 | 14 | 845-849 |
| Immunosuppressive activities of 15-deoxyspergualin in animals. | K. Nemoto; M. Hayashi; F. Abe; T. Nakamura; M. Ishizuka; H. Umezawa | J. Antibiotics | 1987 | 40 | 561-562 |
| Blastogenic responses and the release of interleukins 1 and 2 by spleen cells obtained from rat skin allograft recipients administered with 15-deoxyspergualin. | K. Nemoto; F. Abe; T. Nakamura; M. Ishizuka; T. Takeuchi; H. Umezawa | J. Antibiotics | 1987 | 40 | 1062-1064 |
| Suppression of humoral immunity in dogs by 15-deoxysperhgualin. | K. Nemoto; J. Ito; F. Abe; T. Nakamura; T. Takeuchi; H. Umezawa | J. Antibiotics | 1987 | 40 | 1065-1066 |
| Involvement of cytotoxic T-lymphocytes in the antitumor activity of spergualin against L1210 cells. | H. Umezawa; K. Nishikawa; C. Shibasaki; K. Takahashi; T. Nakamura; T. Takeuchi | Cancer Research | 1987 | 47 | 3062-3065 |
| Suppression of experimental allergic encephalomyelitis in guinea pigs by spergualin and 15-deoxyspergualin. | K. Nemoto; F. Abe; T. Takita; T. Nakamura; T. Takeuchi; H. Umezawa | J. Antibiotics | 1987 | 40 | 1193-1194 |
| Effects of spergualin and 15-deoxyspergualin on the development of graft-versus-host disease in mice. | K. Nemoto; J. Ito; M. Hayashi; F. Abe; Y. Ohtaka; T. Nakamura; T. Takeuchi; H. Umezawa | Transplantation Proceedings | 1987 | 19 | 3520-3521 |
| Effect of spergualin in autoimmune disease mice. | K. Nemoto; M. Hayashi; J. Ito; F. Abe; T. Takita; T. Nakamura; T. Takeuchi; H. Umezawa | J. Antibiotics | 1987 | 40 | 1448-1451 |
| Immunosuppressive activities of deoxyspergualin. II. The effect on the antibody responses. | M. Makino; M. Fujiwara; H. Watanabe; T. Aoyagi; H. Umezawa | Immunopharmacology | 1987 | 14 | 115-122 |
| Effect of 15-deoxyspergualin on graft-v-host disease in mice. | K. Nemoto; M. Hayashi; H. Fujii; J. Ito; T. Nakamura; T. Takeuchi; H. Umezawa | Transplantation Proceedings, No. 5 (October) | 1987 | 19 | 3985-3986 |
| Spergualin: A new antitumour antibiotic. | K. Umezawa; T. Takeuchi | Biomedicine & Pharmacotherapy | 1987 | 41 | 227-232 |
| Assessment of the anti-diabetic activity of deoxyspergualin in low-dose streptozotocin-induced diabetic mice. | K. Nemoto; Y. Sugawara; T. Takita; T. Nakamura; T. Takeuchi | J. Antibiotics | 1988 | 41 | 145-147 |
| Immunosuppressive activity of 15-deoxyspergualin and its effect on skin allografts in rats. | T. Masuda; S. Mizutani; M. Iijima; H. Odai; H. Suda; M. Ishizuka; T. Takeuchi; H. Umezawa | J. Antibiotics | 1987 | 40 | 1612-1618 |
| Suppression of humoral immunity in mice by spergualin. | K. Nemoto; M. Hayashi; F. Abe; T. Nakamura; M. Ishizuka; T. Takeuchi; H. Umezawa | Transplantation Proceedings | 1987 | 19 | 4638-4640 |
| The antiproliferative action of deoxyspergualin is different from that induced by amine oxidase. | H. Kuramochi; M. Hiratsuka; S. Nagamine; K. Takahashi; T. Nakamura; T. Takeuchi; H. Umezawa | J. Antibiotics | 1988 | 41 | 234-238 |
| Immunosuppressive activities of deoxyspergualin. I. Effect of the long-term administration of the drug on the development of murine lupus. | M. Makino; M. Fujiwara; T. Aoyagi; H. Umezawa | Immunopharmacology | 1987 | 14 | 107-114 |
| Immunosuppressive effect of (-)-15-deoxyspergualin on thyroid allograft in mice. (Japanese) | Y. Mazaki; K. Inoue; N. Sato; M. Kamata; M. Ookubo; H. Uchida; K. Sasaki; T. Aoyagi | Ishoku | 1988 | 23 | 35-42 |
| Biological activities of deoxyspergualin in autoimmune disease mice. | K. Nemoto; M. Hayashi; U. Sugawara; J. Ito; F. Abe; T. Takita; T. Nakamura; T. Takeuchi | J. Antibiotics | 1988 | 41 | 1253-1259 |
| Reversal of acute rejection episodes by deoxyspergualin (NKT-01) in dogs receiving renal allografts. | J. Itoh; T. Takeuchi; S. Suzuki; H. Amemiya | J. Antibiotics | 1988 | 41 | 1503-1505 |
| Synthesis and antitumor activity of spergualin analogues. II. Chemical modification of the spermidine moiety. | Y. Umeda; M. Moriguchi; H. Kuroda; T. Nakamura; A. Fujii; H. Iinuma; T. Takeuchi; H. Umezawa | J. Antibiotics | 1987 | 40 | 1303-1315 |
| Synthesis and antitumor activity of spergualin analogues. III. Novel method for synthesis of optically active 15-deoxyspergualin and 15-deoxy-11-O-methylspergualin. | Y. Umeda; M. Moriguchi; K. Ikai; H. Kuroda; T. Nakamura; A. Fujii; T. Takeuchi; H. Umezawa | J. Antibiotics | 1987 | 40 | 1316-1324 |
| Lupus nephropathy in New Zealand F1 hybrid mice treated by (-)-15-deoxyspergualin. | M. Okubo; K. Inoue; N. Umetani; N. Sato; K. Kamata; Y. Masaki; T.Uchiyama; X-J. Yan; T. Aoyagi; T. Shirai | Kidney International | 1988 | 34 | 467-473 |
| Synthesis and biological activity of spergualin analogues. I. | R. Nishizawa; Y. Takei; M. Yoshida; T. Tomiyoshi; T. Saino; K. Nishikawa; K. Nemoto; K. Takahashi; A. Fujii; T. Nakamura; T. Takita; T. Takeuchi | J. Antibiotics | 1988 | 41 | 1629-2643 |
| In vivo effects of deoxyspergualin (NKT-01) on lymphocyte activation in response to alloantigens. | Y. Yoshikawa; H. Uchida; H. Kuroda; T. Nakamura; A. Obayashi; A. Fujii; T. Takeuchi | J. Antibiotics | 1988 | 41 | 1675-1680 |
| Serum effect on cellular uptake of spermidine, spergualin, 15-deoxyspergualin, and their metabolites by L5178Y cells. | S. Kunimoto; C. Nosaka; C.-X. Xu; T. Takeuchi | J. Antibiotics | 1989 | 42 | 116-122 |
| Effects of deoxyspergualin on hematopoiesis: Studies of murine hematopoietic progenitor cell and peripheral blood cell levels. | K. Nemoto; M. Hayashi; Y. Sugawara; F. Abe; T. Takita; T. Takeuchi | J. Antibiotics | 1989 | 42 | 312-316 |
| Inhibition by deoxyspergualin of allo-reactive cytotoxic activity in mouse graft-versus-host disease. | K. Nemoto; M. Hayashi; F. Abe; T. Takita; T. Takeuchi | Transplantation Proceedings | 1989 | 21 | 3028-3030 |
| In vitro immunosuppressive properties of spergualins to murine T cell response. | H. Fujii; T. Takada; K. nemoto; F. Abe; A. Fujii; T. Takeuchi | J. Antibiotics | 1989 | 42 | 788-794 |
| Stability and immunosuppressive activity of deoxyspergualin in comparison with deoxymethylspergualin. | H. Fujii; T. Takada; K. Nemoto; F. Abe; T. Takeuchi | Transplantation Proceedings | 1989 | 21 | 3471-3473 |
| Suppression of the activities of T-lymphocyte-related enzymes in spleen by administration of an immunosuppressant, 15-deoxyspergualin. | T. Aoyagi; T. Wada; H. Iinuma; K. Ogawa; F. Kojima; T. Takeuchi; H. Kuroda; A. Ohbayashi | Biochemistry International | 1989 | 19 | 821-826 |
| Basic studies on spergualins. | S. Kunimoto; M. Ishizuka; H. Iinuma; T. Takeuchi | Gann Monograph on Cancer ResearchJapan Scientific Societies Press, Tokyo/Taylor & Francis Ltd., London | 1989 | 36 | 179-191 |
| Deoxyspergualin directly suppresses antibody formation in vivo and in vitro. | H. Fujii; T. Takada; K. Nemoto; T. Yamashita; F. Abe; A. Fujii; T. Takeuchi | J. Antibiotics | 1990 | 43 | 213-219 |
| Deoxyspergualin therapy in autoimmune MRL/1pr mice suffering advanced lupus-like disease. | K. Nemoto; T. Mae; Y. Sugawara; M. Hayashi; F. Abe; T. Takeuchi | J. Antibiotics | 1990 | 43 | 1590-1596 |
| Therapeutic effect of 15-deoxyspergualin on the progression of lupus nephritis in MRL mice. I. Immunopathological analyses. | S. Ito; M. Ueno; M. Arakawa; T. Saito; T. Aoyagi; M. Fujiwara | Clin. Exp. Immunol. | 1991 | 81 | 446-453 |
| Immunological unresponsiveness by deoxyspergualin therapy in mice undergoing lethal graft-vs-host disease, and successful adoptive transfer of unresponsiveness. | K. Nemoto; Y. Sugawara; T. Mae; M.Hayashi; F. Abe; A. Fujii; T. Takeuchi | Transplantation Proceedings | 1991 | 23 | 862-863 |
| Deoxyspergualin in lethal murine graft-versus-host disease. | K. Nemoto; M. Hayashi; J. Ito; Y. Sugawara; T. Mae; H. Fujii; F. Abe; A. Fujii; T. Takeuchi | Transplantation | 1991 | 51 | 712-715 |
| 15-Deoxyspergualin, an antiproliferative agent for human and mouse leukemia cells shows inhibitory effects on the synthetic pathway of polyamines. | H. Hibasami; T. Tsukada; R. Suzuki; K. Takano; S. Takaji; T. Takeuchi; S. Shirakawa; T. Murata; K. Nakashima | Anticancer Research | 1991 | 11 | 325-330 |
| Toxicological and immunological evaluation of the immunosuppressant 15-deoxyspergualin in BALB/c mice: an in vivo and in vitro study. | M. Okubo; K. Amemiya; K. Kamata; N. Sato; E. Horata; Y. Masaki; T. Uchiyama; T. Aoyagi | Immunopharmacology | 1991 | 21 | 99-108 |
| Reversal of established nephropathy in New Zealand B/W F1 mice by 15-deoxyspergualin. | M. Okubo; N. Umetani; K. Inoue; K. Kamata; Y. Shimoda; T. Uchiyama; T. Aoyagi | Nephron | 1991 | 57 | 99-105 |
| Treatment schedule dependency of antitumor effect of deoxyspergualin. | K. Nishikawa; C. Shibasaki; K. Takahashi; T. Takeuchi | Jap. J. Antibiotics | 1991 | 44 | 917-925 |
| Antitumor spectrum of deoxyspergualin and its lack of cross-resistance to other antitumor agents. | K. Nishikawa; C. Shibasaki; M. Hiratsuka; M. Arakawa; K. Takahashi; T. Takeuchi | J. Antibiotics | 1991 | 44 | 1101-1109 |
| The anture of in vivo cell-killing of deoxyspergualin and its implication in combination with other antitumor agents. | K. Nishikawa; C. Shibasaki; T. Uchida; K. Takahashi; T. Takeuchi | J. Antibiotics | 1991 | 44 | 1237-1246 |
| Effects of deoxyspergualin on dipeptidyl peptidase-II and -IV in the spleen of BXSB mice and MRL/1pr mice during the development of the lupus erythematosus-like syndrome. | M. Hagihara; K. Sekiguchi; M. Fujiwara; T. Aoyagi; T. Takeuchi; T. Nagatsu | Biochemical Pharmacology | 1992 | 43 | 1380-1383 |
| Deoxyspergualin, a novel immunosuppressant, markedly inhibits human mixed lymphocyte reaction and cytotoxic T-lymphocyte activity in vitro. | H. Fujii; T. Takada; K. Nemoto; F. Abe; A. Fujii; J. E. Talmadge; T. Takeuchi | Int. J. Immunopharmacology | 1992 | 14 | 731-737 |
| Therapeutic activity of deoxyspergualin in comparison with cytclosporin A, and its combined use with cyclosporin A and prednisolone in highly allogeneic skin transplantation in the rat. | K. Nemoto; Y. Sugawara; T. Mae; M. Hayashi; F. Abe; A. Fujii; T. Takeuchi | Agents Actions | 1992 | 36 | 306-311 |
| Suppression of experimental autoimmune myasthenia gravis with new immunosuppressants: 15-Deoxyspergualin and actinobolin. | Y. Ishigaki; T. Sato; D-L. Song; K. Hayashi; T. Aoyagi | J. Neurological Sciences | 1992 | 112 | 209-215 |
| Anti-angiogenic effect of 15-deoxyspergualin in angiogenensis model system involving human microvascular endothelial cells. | A. Kiue; T. Abe; A. Morimoto; K. Okamura; M. Ono; K. Kohno; T. Oikawa; T. Iwaguchi; M. Ishizuka; T. Takeuchi; M. Kuwano | The Cancer Journal | 1992 | 5 | 267-271 |
| Synthesis and background chemistry of 15-deoxyspergualin. | K. Maeda; Y. Umeda; T. Saino | Immunomodulating Drugs, The Annals of the New York Academy of Sciences, The New York Academy of Sciences | 1993 | 685 | 123-135 |
| Successful treatment with a novel immunosuppressive agent, deoxyspergualin, in type II collagen-induced arthritis in mice. | K. Nemoto; T. Mae; F. Abe; T. Takeuchi | Immunomodulating Drugs, The Annals of the New York Academy of Sciences, The New York Academy of Sciences | 1993 | 685 | 148-154 |
| Therapeutic studies of the combination of deoxyspergulain and prednisolone in MRL/1pr mice with advanced lupus-like disease. | T. Mae; K. Nemoto; Y. Sugawara; F. Abe; T. Takeuchi | J. Antibiotics | 1994 | 47 | 90-94 |
| Improvement of mitomycin C- and cyclophosphamide-induced thrombocytopenia and leucocytopenia by prior treatment with deoxyspergualin in dogs. | K. Nemoto; M. Ogino; Y. Sugawara; F. Abe; J. Ito; T. Takeuchi | British Journal of Haematology | 1994 | 87 | 572-575 |
| Kinetic studies of the interaction between spergualin or 15-deoxyspergualin and amine oxidase from bovine plasma. | S. Kunimoto; T. Takeuchi | J. Antibiotics | 1994 | 47 | 1130-1135 |