Compounds

Cytostatin

Cytostatin_1

Producing organism:

Streptomyces sp. MJ654-NF4

Activity:

Protein phosphatase 2A inhibitor, Cell adhesion inhibitor

Clinical use:

-

Class no:

4 Reference(s)

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Title	Author	Journal	Year	Volume	Page
Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produed by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities.	M. Amemiya; M. Ueno; M. Osono; T. Masuda; N. Kinoshita; C. Nishida; M. Hamada; M. Ishizuka; T. Takeuchi	J. Antibiotics	1994	47	536-540
Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. II. Physico-chemical properties and structure determination.	M. Amemiya; T. Someno; R. Sawa; H. Naganawa; M. Ishizuka; T. Takeuchi	J. Antibiotics	1994	47	541-544
Inhibitory effect of cytostatin on spontaneous lung metastasis of B16-BL6 melanoma cells.	T. Masuda; S. Watanabe; M. Amemiya; M. Ishizuka; T. Takeuchi	J. Antibiotics	1995	48	528-529
Screening for apoptosis inducers in microbial products and induction of apoptosis by cytostatin.	K. Yamazaki, M. Amemiya; M. Ishizuka; T. Takeuchi	J. Antibiotics	1995	48	1138-1140