Compounds

Coformycin

Coformycin_1

Producing organism:

Nocardia interforma

Activity:

Inhibitor of adenosine deaminase

Clinical use:

-

Class no:

8 Reference(s)

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Title	Author	Journal	Year	Volume	Page
Mode of inhibition of coformycin on adenosine deaminase.	T. Sawa; Y. Fukagawa; I. Homma; T. Takeuchi; H. Umezawa	J. Antibiotics	1967	20	227-231
Synthesis of coformycin.	M. Ohno; N. Yagisawa; S. Shibahara; S. Kondo; K. Maeda; H. Umezawa	J. Am. Chem. Soc.	1974	96	4326
Structure of coformycin, an unusual nucleoside of microbial origin.	M. Ohno; N. Yagisawa; S. Kondo; K. Maeda; H. Umezawa; H. Nakamura	J. Am. Chem. Soc.	1974	96	4327-4328
The crystal and molecular structure of coformycin.	H. Nakamura; G. Koyama; H. Umezawa; Y. Iitaka	Acta Crystallographica	1976	B32	1206
Synthesis of isocoformycin, an adenosine deaminase inhibitor of synthetic origin.	M. Shimazaki; S. Kondo; K. Maeda; M. Ohno; H. Umezawa	J. Antibiotics	1979	32	537-538
Studies on inhibition of adenosine deaminase by isocoformycin in vitro and in vivo.	M. Shimazaki; Y.Kumada; T. Takeuchi; H. Umezawa; K. Watanabe	J. Antibiotics	1979	32	654-658
Effects of a new adenosine deaminase inhibitor, isocoformycin, on toxicity, antitumor activity and tissue distribution of formycin A and 9-β-D-arabinofuranosyladenine.	T. Hidaka; K. katayama; K. Yamashita; T. Yamashita; K. Watanabe; M. Shimazaki; M. Ohno; T. Takeuchi; H. Umezawa	J. Antibiotics	1980	33	303-309