Compounds
Bestatin (Ubenimex)
Producing organism:
Streptomyces oliboreticuli MD976-C7
Activity:
Inhibitor of aminopeptidase Bleucine aminopeptidasealanine aminopeptidasetripeptidyl and tetrapeptidyl aminopeptidaseImmunomodulator,Antitumor Agent
Clinical use:
Immunomodulator,Antineoplastic
Class no:
48 Reference(s)
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| Title | Author | Journal | Year | Volume | Page |
|---|---|---|---|---|---|
| Bestatin, an inhibitor of aminopeptidase B, produced by Actinomycetes. | H. Umezawa; T. Aoyagi; H. Suda; M. Hamada; T. Takeuchi | J. Antibiotics | 1976 | 29 | 97-99 |
| The structure of bestatin. | H. Suda; T. Takita; T. Aoyagi; H. Umezawa | J. Antibiotics | 1976 | 29 | 100-101 |
| X-ray structure determination of (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid, a new amino acid component of bestatin. | H. Nakamura; H. Suda; T. Takita; T. Aoyagi; H. Umezawa | J. Antibiotics | 1976 | 29 | 102-103 |
| The chemical synthesis of bestatin. | H. Suda; T. Takita; T. Aoyagi; H. Umezawa | J. Antibiotics | 1976 | 29 | 600-601 |
| Enhancement of delayed-type hypersensitivity by bestatin, an inhibitor of aminopeptidase B and leucine aminopeptidase. | H. Umezawa; M. Ishizuka; T. Aoyagi; T. Takeuchi | J. Antibiotics | 1976 | 29 | 857-859 |
| Inhibition of aminopeptidase B and leucine aminopeptidase by bestatin and its stereoisomer. | H. Suda; T. Aoyagi; T. Takeuchi; H. Umezawa | Archiv. Biochem. Biophys. | 1976 | 177 | 196-200 |
| Synthesis and structure-activity relationships of bestatin analogs, inhibitors of aminopeptidase B. | R. Nishizawa; T. Saino; T. Takita; H. Suda; T. Aoyagi; H. Umezawa | J. Med. Chem. | 1977 | 20 | 510-515 |
| Bestatin, a new specific inhibitor of aminopeptidases, enhances activation of small lymphocytes by concanavalin A. | M. Saito; T. Aoyagi; H. Umezawa; Y. Nagai | Biochem. Biophys. Res. Commun. | 1977 | 76 | 526-533 |
| Stimulatory effect of bestatin, a new specific inhibitor of aminopeptidases, on the blastogenesis of guinea pig lymphocytes. | M. Saito; K. Takegoshi; T. Aoyagi; H. Umezawa; Y. Nagai | Cellular Immunology | 1978 | 40 | 247-264 |
| Activation of DNA metabolism in T-cells by bestatin. | W. E. G. Mueller; R. K. Zahn; J. Arendes; N. Munsch; H. Umezawa | Biochem. Pharmacol. | 1979 | 28 | 3131-3137 |
| Effect of bestatin on mouse immune system and experimental murine tumors. | M. Ishizuka; T. Masuda; N. Kanbayashi; S. Fukasawa; T. Takeuchi; T. Aoyagi; H. Umezawa | J. Antibiotics | 1980 | 33 | 642-652 |
| Mitogenic effect of bestatin on lymphocytes. | M. Ishizuka; J. Sato; Y. Sugiyama; T. Takeuchi; H. Umezawa | J. Antibiotics | 1980 | 33 | 653-662 |
| Synthesis of bestatin and its analogues and their bioactivity. (Japanese) | H. Umezawa; T. Takita | Yuki Gosei Kagaku Kyokaishi | 1980 | 38 | 1077-1083 |
| A review of clinical studies of bestatin. | S. Oka | Recent Results in Cancer Research | 1980 | 75 | 126-132 |
| Screening of small molecular microbial products modulating immune responses and bestatin. | H. Umezawa | Recent Results in Cancer Research | 1980 | 75 | 115-125 |
| Fundamental studies on bestatin: A small molecular microbial product enhancing immune responses. | H. Umezawa | Recent Results in Cancer Research | 1981 | 76 | 209-221 |
| A review of clinical studies on bestatin, 1976-1978. | S. Oka | Recent Results in Cancer Research | 1981 | 76 | 222-231 |
| Properties and specificity of binding sites for the immunomodulator bestatin on the surface of mammalian cells. | W. E. G. Mueller; D. Schuster; R. K. Zahn; A. Maidhof; G. Leyhausen; D. Falke; R. Koren; H. Umezawa | Int. J. Immunopharmacol. | 1982 | 4 | 393-400 |
| Restoration of impaired immune functions of aged animals by chronic bestatin treatment. | M. Bruley-Rosset; I. Florentin; N. Kiger; J. Schulz; G. Mathe | Immunology | 1979 | 38 | 75-83 |
| Identification and properties of the cell membrane bound leucine aminopeptidase interacting with the potential immunostimulant and chemotherapeutic agent bestatin. | G. Leyhausen; D. K. Schuster; P. Vaith; R. K. Zahn; H. Umezawa; D. Falke; W. E. G. Mueller | Biochemical Pharmacology | 1983 | 32 | 1051-1057 |
| Immunochemical identification of the cell surface bound leucine aminopeptidase, the target enzyme for the immunostimulant bestatin. | G. Leyhausen; M. Gramzow; R. K. Zahn; R. Steffen; H. Umezawa; W. E. G. Mueller | J. Antibiotics | 1983 | 36 | 728-734 |
| Studies of the potential usefulness of bestatin in cancer treatment. | H. Umezawa | Cancer Treatment Symposia | 1983 | 1 | 15-18 |
| Effect of bestatin on syngeneic tumors in mice. | F. Abe; K. Shibuya; M. Uchida; K. Takahashi; H. Horinishi; A. Matsuda; M. Ishizuka; T. Takeuchi; H. Umezawa | Gann | 1984 | 75 | 89-94 |
| Antitumor effect of bestatin combined with bleomycin against hepatoma AH66 subcutaneously transplanted in rats. (Japanese) | F. Abe; T. Yamashita; K. Takahashi; A. Matsuda; T. Ichikawa; H. Umezawa | Jap. J. Antibiotics | 1984 | 37 | 589-592 |
| Biological effect of bestatin against rat ascites hepatomas and enhancement of interferon production. (Japanese) | H. Sato | Jap. J. Antibiotics | 1984 | 9 | 405-987 |
| Studies on low moelcular weight immunomodifiers, bestatin, etc. Discovery and actions. | H. Umezawa | Drugs Exptl. Clin. Res. | 1984 | 10 | 519-531 |
| Oscillation of enzyme networks in spleen triggered by an immunopotentiator, bestatin. | T. Aoyagi; T. Wada; S. Ohuchi; F. Kojima; M. Nagai; F. Kawahara; H. Umezawa | Biochemistry International | 1984 | 9 | 405-411 |
| Different enzymatic oscillations in vivo caused by the stereoisomers of an aminopeptidase inhibitor, bestatin. | T. Aoyagi; T. Wada; K. Yamamoto; F. Kojima; M. Nagai; S. Harada; H. Umezawa | J. Appl. Biochem. | 1984 | 6 | 212-221 |
| In vivo actions of bestatin-related compounds in relation to their actions in vitro. | T. Aoyagi; T. Wada; S. Ohuchi; K. Kawamura; S. Fukatsu; H. Umezawa | Biochemistry International | 1985 | 9 | 643-650 |
| Enhancement of antitumor effect of cytotoxic agents by bestatin. | F. Abe; K. Shibuya; J. Ashizawa; K. Takahashi; H. Horinishi; A. Matsuda; M. Ishizuka; T. Takeuchi; H. Umezawa | J. Antibiotics | 1985 | 38 | 411-414 |
| Mitogenic potentials of bestatin, amastatin, arphamenines A and B, FK-156 and FK-565 on spleen lymphocytes. | N. Weissmann; G. Leyhausen; A. Maidhof; W. Tanaka; H. Umezawa; W. E. G. Mueller | J. Antibiotics | 1985 | 38 | 772-778 |
| Potentiation of the bleomycin, arabinofuranosylcytosine and adriamycin-caused inhibition of DNA synthesis in lymphocytes by bestatin in vitro. | G. Leyhausen; H. C. Schroeder; D. K. Schuster; A. Maidhof; H. Umezawa; W. E. G. Mueller | Eur. J. Cancer Clin. Oncol. | 1985 | 21 | 1325-1330 |
| Bestatin, a microbial aminopeptidase inhibitor, inhibits DNA synthesis induced by insulin or epidermal growth factor in primary cultured rat hepatocytes. | S. Takahashi; H. Kato; T. Seki; T. Noguchi; H. Naito; T. Aoyagi; H. Umezawa | J. Antibiotics | 1985 | 38 | 1767-1773 |
| Cell surface-bound leucine aminopeptidase: Target of the immunomodulator bestatin. | W. E. G. Mueller; D. K. Schuster; G. Leyhausen; C. Sobel; H. Umezawa | Cellular Biology of Ectoenzymes (Ed. G. W. Kreutzberg et al.)Springer-Verlag | 1986 | 36 | 285-293 |
| Bestatin suppresses the serum levels of several hydrolytic enzymes in a patient with progressive muscular dystrophy. | T. Aoyagi; T. Wada; F. Kojima; M. Nagai; S. Harada; M. Kinoshita; N. Yamada; H. Umezawa | J. Clin. Biochem. Nutr. | 1986 | 1 | 65-72 |
| Biosynthesis of an unusual amino acyl moiety contained in bestatin. | A. Okuyama; H. Naganawa; S. Harada; T. Aoyagi; H. Umezawa | Biochemistry International | 1986 | 12 | 627-631 |
| Bestatin: a low molecular immunomodifier. | H. Umezawa; M. Ishizuka | Natural Immunity, Cancer and Biological Response Modification (Eds. E. Lotzova; R. B. Herberman)Karger, Basel | 1986 | 272-279 | |
| Bestatin, a low moelcular weight immunomodifier produced by microorganisms. | H. Umezawa; M. Ishizuka; T. Takeuchi; F. Abe; K. Shibuya | Developments in Industrial Microbiology (J. Industrial Microbiology Suppl. No. 1) (Ed. G. Pierce)Society for Industrial Microbiology | 1987 | 27 | 31-36 |
| Enhancement of interleukin 1 and interleukin 2 releases by ubenimex. | K. Shibuya; E. Hayashi; F. Abe; K. Takahashi; H. Horinishi; M. Ishizuka; T. Takeuchi; H. Umezawa | J. Antibiotics | 1987 | 40 | 363-369 |
| Antitumor cells found in tumor-bearing mice given ubenimex. | M. Ishizuka; T. Masuda; S.Mizutani; T. Takeuchi; H. Umezawa | J. Antibiotics | 1987 | 40 | 697-701 |
| Enhancement of colony formation of mouse bone marrow cells by ubenimex. | K. Nemoto; F. Abe; K. Karakawa; H. Horinishi; H. Umezawa | J. Antibiotics | 1987 | 40 | 894-898 |
| Synthesis of p-hydroxyubenimex. | T. Saino; K. Seya; R. Nishizawa; T. Takita; T. Aoyagi; H. Umezawa | J. Antibiotics | 1987 | 40 | 1165-1169 |
| Action of ubenimex on aminopeptidase activities in spleen cells and peritoneal macrophages from mice. | H. Kuramochi; A. Motegi; M. Iwabuchi; K. Takahashi; H. Horinishi; H. Umezawa | J. Antibiotics | 1987 | 40 | 1605-1611 |
| Effect of ubenimex on the production of murine interferon. | A. Okura; M. Ishizuka; T. Takeuchi | J. Antibiotics | 1988 | 41 | 261-263 |
| The effect of bestatin, a microbial aminopeptidase inhibitor, on epidermal growth factor-induced DNA synthesis and cell division in primary cultured hepatocytes of rats. | S. Takahashi; Y. Ohishi; H. Kato; T. Noguchi; H. Naito; T. Aoyagi | Experimental Cell Research | 1989 | 183 | 399-412 |
| Enhancement of host resistance to opportunistic infections by ubenimex (bestatin). | M. Ishizuka; F. Abe; S. Abe; K. Uchida; T. Ikeda; N. Ito; K. Aoyagi; H. Yamaguchi; T. Takeuchi | Microbial Infections. H. Friedman, et al. Eds., Plenum Press, New York | 1992 | 319 | 193-200 |
| Enhancement by ubenimex (bestatin) of host resistance to Candida albicans infection. | K. Aoyagi; N. Itoh; F. Abe; S. Abe; K. Uchida; M. Ishizuka; T. Takeuchi; H. Yamaguchi | J. Antibiotics | 1992 | 45 | 1778-1784 |
| Purification and characterization of a ubenimex (bestatin)-sensitive aminopeptidase β-like enzyme from K562 human chronic myeloid leukemia cells. | M. Yamada; Y. Sukenaga; H. Fujii; F. Abe; T. Takeuchi | FEBS Letters | 1994 | 342 | 53-56 |