Compounds

Pronqodine A

Pronqodine A_1

Producing organism:

Streptomyces sp. MK832-95F2

Activity:

Prostaglandin Release Inhibitor, antitumor

Clinical use:

-

Class no:

1 Reference

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Title Author Journal Year Volume Page
NAD(P)H quinone oxidoreductase 1 (NQO1)-bioactivated pronqodine A
regulates prostaglandin release from human synovial sarcoma cells.		 K. Nakae, H. Adachi, R. Sawa, N. Hosokawa, M. Hatano, M. Igarashi, Y. Nishimura, Y. Akamatsu and A. Nomoto. J. Natural Products 2013 76 510-515
Discovery of proqodine A derivatives with antitumor activity targeting NAD(P)H: quinone oxidoreductase 1 and nicotinamide phosphoribosyltransferase SONG Jiangzhou1, ZOU Guiqing, ZHAO Zhou, ZHU Ya, XUE Jiayu, AO Lanjia, SUN Huiyong, HAO Haiping*, ZHANG Bo*, XU Xiaowei Chinese Journal of Natural Medicines 2024 22 75-88 doi: 10.1016/S1875-5364(24)60564-9