Compounds
Siastatin
Producing organism:
Streptomyces verticillus var. quinntum
Activity:
-
Clinical use:
-
Class no:
16 Reference(s)
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| Title | Author | Journal | Year | Volume | Page |
|---|---|---|---|---|---|
| Purification and characterization of a sialidase inhibitor, siastatin, produced by Streptomyces. | H. Umezawa; T. Aoyagi; T. Komiyama; H. Morishima; M. Hamada; T. Takeuchi | J. Antibiotics | 1974 | 27 | 963-969 |
| Siastatin B, a potent neuraminidase inhibitor: The total synthesis and absolute configuration. | Y. Nishimura; Wen-mei Wang; S. Kondo; T. Aoyagi; H. Umezawa | J. Am. Chem. Soc. | 1988 | 110 | 7249-7250 |
| Total synthesis of siastatin B and its enantiomer using carbohydrate as a chiral educt. | Y. Nishimura; W.-M. Wang; T. Kudo; S. Kondo | Bull. Chem. Soc. Jpn. | 1992 | 65 | 978-986 |
| Totally synthetic analogues of siastatin B. I. Optically active 2-acetamidopiperidine derivatives. | T. Kudo; Y. Nishimura; S. Kondo; T. Takeuchi | J. Antibiotics | 1992 | 45 | 954-962 |
| Totally synthetic analogues of siastatin B. II. Optically active piperidine derivatives having trifluoroacetamide and hydroxyacetamide groups AT C-2. | Y. Nishimura; T. Kudo; S. Kondo; T. Takeuchi | J. Antibiotics | 1992 | 45 | 963-970 |
| Potent inhibition of neuraminidase by N-(1,2-dihydroxypropyl) derivatives of siastatin B and its analogs. | Y. Nishimura; T. Kudo; Y. Umezawa; S. Kondo; T. Takeuchi | Natural product Letters | 1992 | 1 | 33-38 |
| Design of potential neuraminidase inhibitors by dehydration, deoxygenation and epimerization of siastatin B. | Y. Nishimura; T. Kudo; Y. Umezawa; S. Kondo; T. Takeuchi | Natural Product Letters | 1992 | 1 | 39-44 |
| Syntheses and activities of N-substituted derivatives of siastatin B. | T. Kudo; Y. Nishimura; S. Kondo; T. Takeuchi | J. Antibiotics | 1992 | 45 | 1662-1668 |
| Syntheses of the potent inhibitors of neuraminidase, N-(1,2-dihydroxypropyl) derivatives of siastatin B and its 4-deoxy analogs. | T. Kudo; Y. Nishimura; S. Kondo; T. Takeuchi | J. Antibiotics | 1993 | 46 | 300-309 |
| Synthesis of 3-episiastatin B analogues having anti-influenza virus activity. | Y. Nishimura; Y. Umezawa; S. Kondo; T. Takeuchi; K. Mori; I. Kijima-Suda; K. Tomita; K. Sugawara; K. Nakamura | J. Antibiotics | 1993 | 46 | 1883-1889 |
| Totally synthetic analogues of siastatin B. III. Trifluoroacetamide analogues having inhibitory activity for tumor metastasis. | Y. Nishimura; T. Kudo; S. Kondo; T. Takeuchi; T. Tsuruoka; H. Fukuyasu; S. Shibahara | J. Antibiotics | 1994 | 47 | 101-107 |
| Effect on spontaneous metastasis of mouse Lewis lung carcinoma by a trifluoroacetamide analogue of siastatin B. | Y. Nishimura; T. Satoh; S. Kondo; T. Takeuchi; M. Azetaka; H. Fukuyasu; Y. Iizuka; S. Shibahara | J. Antibiotics | 1994 | 47 | 840-842 |
| Synthesis and activity of 1-N-iminosugar inhibitors, siastatin B analogue for α-N-acetylgalactosaminidase and β-N-acetylglucosaminidase. | Y. Nishimura; T. Satoh; T. Kudo; S. Kondo; T. Takeuchi | Bioorganic and Medicinal Chemistry | 1996 | 4 | 91-96 |
| Synthesis and antimetastatic activity of 6-trichloroacetamido and 6-guanidino analogues of siastatin B. | T. Satoh; Y. Nishimura; S. Kondo; T. Takeuchi; M. Azetaka; H. Fukuyasu; Y. Iizuka; S. Ohuchi; S. Shibahara | J. Antibiotics | 1996 | 49 | 321-325 |
| A practical synthesis from siastatin B of (3S,4S,5R,6R)-4,5-dihydroxy-6-(trifluoroacetamido)- piperidine-3-carboxylic acid having antimetastatic activity in mice. | T. Satoh; Y. Nishimura; S. Kondo; T. Takeuchi | Carbohydrate Research | 1996 | 286 | 173-178 |
| Synthesis of iminosugar glycosidase inhibitors modeled on siastatin B directed toward new agents for tumor metastasis and viral infection. (Japanese) | Y. Nishimura | Yuki Gosei Kagaku Kyoukaishi | 1997 | 55 | 142-151 |