Compounds
Poststatin
Producing organism:
Streptomyces viridochrmogenes MH534-30F
Activity:
Inhibitor of prolyl endopeptidase
Clinical use:
-
Class no:
11 Reference(s)
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| Title | Author | Journal | Year | Volume | Page |
|---|---|---|---|---|---|
| Synthesis and endopeptidase inhibitory activity of poststatin and its analogues. | M. Tsuda; Y. Muraoka; M. Nagai; T. Aoyagi; T. Takeuchi | Peptide Chemistry 1990 (Ed. Y. Shimonishi)Protein Research Foundation, Osaka | 1991 | ||
| Poststatin, a new inhibitor of prolyl endopeptidase, produced by Streptomyces viridochromogenes MH534-30F3. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. | T. Aoyagi; M. Nagai; K. Ogawa; F. Kojima; M. Okada; T. Ikeda; M. Hamada; T. Takeuchi | J. Antibiotics | 1991 | 44 | 949-955 |
| Poststatin, a new inhibitor of prolyl endopeptidase, produced by Streptomyces viridochromogenes MH534-30F3. II. Structure determination and inhibitory activities. | M. Nagai; K. Ogawa; Y. Muraoka; H. Naganawa; T. Aoyagi; T. Takeuchi | J. Antibiotics | 1991 | 44 | 956-961 |
| Synthesis and endopeptidase inhibitory activity of the poststatin related peptides. | Y. Muraoka; M. Tsuda; M. Nagai; T. Aoyagi; T. Takeuchi; T. Someno; F. Yamada; H. Sugimura | Proceedings of the 4th Akabori Conference Japanese-German Symposium on Peptide Chemistry (October 7-10, 1991, Shizuoka, Japan)Protein Research Foundation | 1992 | 114-119 | |
| Poststatin, a novel inhibitor of bradykinin-degrading enzymes in rat urine. | M. Majima; C. Shima; M. Saito; Y. Kuribayashi; M. Katori; T. Aoyagi | European Journal of Pharmacology | 1993 | 232 | 181-190 |
| Poststatin, a new inhibitor of prolyl endopeptidase III. Optical resolution of 3-amino-2-hydroxyvaleric acid and absolute configuration of poststatin. | M. Tsuda; Y. Muraoka; M. Nagai; T. Aoyagi; T. Takeuchi | J. Antibiotics | 1996 | 49 | 281-286 |
| Poststatin, a new inhibitor of prolyl endopeptidase IV. The chemical synthesis of poststatin. | M. Tsuda; Y. Muraoka; M. Nagai; T. Takeuchi; T. Aoyagi | J. Antibiotics | 1996 | 49 | 287-291 |
| Poststatin, a new inhibitor of prolyl endopeptidase V. Endopeptidase inhibitory activity of poststatin analogues. | M. Tsuda; Y. Muraoka; M. Nagai; T. Aoyagi; T. Takeuchi | J. Antibiotics | 1996 | 49 | 890-899 |
| Poststatin, a new inhibitor of prolyl endopeptidase VI. Endopeptidase inhibitory activity of poststatin analouges containing pyrrolidine ring. | M. Tsuda; Y. Muraoka; T. Someno; M. Nagai; T. Aoyagi; T. Takeuchi | J. Antibiotics | 1996 | 49 | 900-908 |
| Poststatin, a new inhibitor of prolyl endopeptidase VII. N-cycloalkylamide analogues. | M. Tsuda; Y. Muraoka; M. Nagai; T. Aoyagi; T. Takeuchi | J. Antibiotics | 1996 | 49 | 909-920 |
| Poststatin, a new inhibitor of prolyl endopeptidase VIII. Endopeptidase inhibitory activity of non-peptidyl poststatin analogues. | M. Tsuda; Y. Muraoka; M. Nagai; T. Aoyagi; T. Takeuchi | J. Antibiotics | 1996 | 49 | 1022-1030 |