Compounds

Oudenone

Oudenone_1

Producing organism:

Oudemansiella

Activity:

Tyrosine hydroxylase inhibitor

Clinical use:

-

Class no:

6 Reference(s)

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Title Author Journal Year Volume Page
A new microbial product, oudenone, inhibiting tyrosine hydroxylase. H. Umezawa; T. Takeuchi; H. Iinuma; K. Suzuki; M. Ito; M. Matsuzaki J. Antibiotics 1970 23 514-518
Oudenone; a novel tyrosine hydroxylase inhibitor from microbial origin. M. Ohno; M. Okamoto; N. Kawabe; H. Umezawa; T. Takeuchi; H. Iinuma; S. Takahashi J. Am. Chem. Soc. 1971 93 1285-1286
Effect of oudenone on adrenal tyrosine hydroxylase activity in vivo and on tissue catecholamine concentrations. T. Nagatsu; I. Nagatsu; H. Umezawa Biochemical Pharmacology 1971 20 2505-2507
Inhibition of phenylalanine hydroxylase, a pterin-requiring monooxygenase, by oudenone and its derivatives. S. Koizumi; T. Nagatsu; H. Iinuma; M. Ohno; T. Takeuchi; H. Umezawa J. Antibiotics 1982 35 458-462
Studies on phenylalanine hydorxylase inhibitor, oudenone and its derivaives produced by microorganism. (Japanese) H. Umezawa; T. Nagatsu 1981 13-21
Kinetic analysis of the inhibition of tryptophan hydroxylase, a pteridine-requiring monooxygenase, by oudenone and its derivatives. M. Sawada; H. Iinuma; M. Ohno; T. Takeuchi; H. Umezawa; T. Nagatsu Biogenic Amines 1984 1 171-178