Compounds
Leupeptin
Producing organism:
Streptomyces roseus MA839-A1, MB262-M1
Activity:
Proteinase inhibitor, Anti influenza virus
Clinical use:
-
Class no:
24 Reference(s)
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| Title | Author | Journal | Year | Volume | Page |
|---|---|---|---|---|---|
| Leupeptins, new protease inhibitors from Actinomycetes. | T. Aoyagi; T. Takeuchi; A. Matsuzaki; K. Kawamura; S. Kondo; M. Hamada; K. Maeda; H. Umezawa | J. Antibiotics | 1969 | 22 | 283-286 |
| Isolation and characterization of leupeptins produced by Actinomycetes. | S. Kondo; K. Kawamura; J. Iwanaga; M. Hamada; T. Aoyagi; K. Maeda; T. Takeuchi; H. Umezawa | Chem. Pharm. Bull. | 1969 | 17 | 1896-1901 |
| Structures and syntheses of leupeptins Pr-LL and Ac-LL. | K. Kawamura; S. Kondo; K. Maeda; H. Umezawa | Chem. Pharm. Bull. | 1969 | 17 | 1902-1909 |
| Biological activities of leupeptins. | T. Aoyagi; S. Miyata; M. Nanbo; F. Kojima; M. Matsuzaki; M. Ishizuka; T. Takeuchi; H. Umezawa | J. Antibiotics | 1969 | 22 | 558-568 |
| The structure and activity of leupeptins and related analogs. | K. Maeda; K. Kawamura; S. Kondo; T. Aoyagi; T. Takeuchi; H. Umezawa | J. Antibiotics | 1971 | 24 | 402-404 |
| Inhibition of tumorigenesis in mouse skin by leupeptin, a protease inhibitor from Actinomycetes. | M. Hozumi; M. Ogawa; T. Sugimura; T. Takeuchi; H. Umezawa | Cancer Research | 1972 | 32 | 1725-1728 |
| Leupeptin, a protease inhibitor, inhibits the PHA-stimulated DNA synthesis in guinea pig blood lymphocytes. | M. Saito; T. Hagiwara; T. Aoyagi; Y. Nagai | Jap. J. Experimental Medicine | 1972 | 42 | 509-511 |
| Synthetic studies on leupeptins and their analogs. | B. Shimizu; A. Saito; a. Ito; K. Tokawa; K. Maeda; H. Umezawa | J. Antibiotics | 1972 | 25 | 515-523 |
| An alternate synthesis of leupeptins and their analogs. | H. Saeki; Y. Shimada; N. Kawakita; B. Shimuzu; E. Ohki; K. Maeda; H. Umezawa | Chem. Pharm. Bull. | 1973 | 21 | 163-170 |
| プロテアーゼ阻害剤（ロイペプチン）による発癌過程の抑制ー発癌過程抑制可能のもつ生物学的意義 (Japanese) | M. Hozumi; M. Ogawa; E. Mizunoe; S. Miyake; K. Shimazaki; I. Ishikawa; T. Sugimura; S. Fujimura; T. Takeuchi; H. Umezawa | Igaku no Ayumi | 1973 | 87 | 22-27 |
| アゾキシメタンによる大腸癌発生のロイペプチンによる抑制 (Japanese) | T. Matsushima; R.S. Yamamoto; K. Hara; T. Sugimura; T. Takeuchi; H. Umezawa | Igaku no Ayumi | 1974 | 88 | 710-714 |
| Effect of leupeptin on induction of lymphoblastic leukemia in mice by N-nitrosobutylurea.=587 | T. Kakizoe; T. Sano; T. Kawachi; T. Sugimura; T. Takeuchi; H. Umezawa | Gann | 1977 | 68 | 281-285 |
| Effect of leupeptin on induction of lymphoblastic leukemia in mice by N-nitrosobutylurea. =560 | T. Kakizoe; T. Sano; T. Kawachi; T. Sugimura; T. Takeuchi; H. Umezawa | Gann | 1977 | 68 | 281-285 |
| Further studies on the effect of leupeptin, a protease inhibitor on induction of bladder tumors in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine. | T. Kakizoe; H. Esumi; T. Kawachi, T. Sugimura; T. Takeuchi; H. Umezawa | J. Nat. Cancer Inst. | 1977 | 59 | 1503-1508 |
| Biosynthesis of leupeptin. | M. Hori; M. Hemmi; K. Suzukake; H. Hayashi; Y. Uehara; T. Takeuchi; H. Umezawa | J. Antibiotics | 1978 | 31 | 95-98 |
| Biosynthesis of leupeptin. II. Purification and properties of leupeptin acid synthetase. | K. Suzukake; T. Fujiyama; H. Hayashi; M. Hori; H. Umezawa | J. Antibiotics | 1979 | 32 | 523-530 |
| Biosynthesis of leupeptin. III. Isolation and properties of an enzyme synthesizing acetyl-L-leucine. | K. Suzukake; H. Hayashi; M. Hori; H. Umezawa | J. Antibiotics | 1980 | 33 | 857-862 |
| Biosynthesis of leupeptin. IV. Is protein turnover in leupeptin producer cells affected by leupeptin? | K. Suzukake; M. Takada; M. Hori; H. Umezawa | J. Antibiotics | 1980 | 33 | 1172-1176 |
| Purification and properties of an enzyme reducing leupeptin acid to leupeptin. | K. Suzukake; M. Hori; O. Tamemasa; H. Umezawa | Biochim. Biophys. Acta | 1981 | 661 | 175-181 |
| Biosynthesis of leupeptin. | K. Suzukake; M. Hori; H. Hayashi; H. Umezawa | Peptpde Antibiotics - Biosynthesis and Functions (Eds. H. Kleinkauf & H. v. Doehren) | 1982 | 325-336 | |
| Assay of plasma leupeptin using the reversible binding of leupeptin to bovine pancreatic trypsin. | K. Yamashita; K. Watanabe; H. Takayama; S. Mizuguchi; M. Ishibashi; H. Miyazaki; W. Tanaka; H. Umezawa | Analytical Biochemistry | 1986 | 156 | 503-507 |
| Protease-inhibitory activities of leupeptin analogues. | T. Saino; T. Someno; S.Ishii; T. Aoyagi; H. Umezawa | J. Antibiotics | 1988 | 41 | 220-225 |