Compounds

Hydroxypepstatin

Hydroxypepstatin_1

Producing organism:

Streptomyces testaceusStreptomyces parvisporogen strain MD494-A1

Activity:

Pepsin (aspartic proteinase) inhibitor

Clinical use:

-

Class no:

19 Reference(s)

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Title Author Journal Year Volume Page
The structure of pepstatin. H. Morishima; T. Takita; T. Aoyagi; T. Takeuchi; H. Umezawa J. Antibiotics 1970 23 263-265
Pepstatin, a new pepsin inhibitor produced by Actinomycetes. H. Umezawa; T. Aoyagi; H. Morishima; M. Matsuzaki; M. Hamada; T. Takeuchi J. Antibiotics 1970 23 259-262
Effect of pepstatin on acid proteases. T. Aoyagi; S. Kunimoto; H. Morishima; T. Takeuchi; H. Umezawa J. Antibiotics 1971 24 687-694
Mechansim of inhibition of pepsin by pepstatin. S. Kunimoto; T. Aoyagi; H. Morishima; T. Takeuchi; H. Umezawa J. Antibiotics 1972 25 251-255
New pepstatins, pepstatins B and C and pepstanone A, produced by Streptomyces. T. Miyano; M. Tomiyasu; H. Iizuka; S. Tomisaka; T. Takita; T. Aoyagi; H. Umezawa J. Antibiotics 1972 25 489-491
The chemical synthesis of pepstatin A. H. Morishima; T. Takita; H. Umezawa J. Antibiotics 1972 25 551-552
Biological activity of pepstatins, pepstanone A and partial peptides on pepsin, cathepsin D and renin. T. Aoyagi; H. Morishima; R. Nishizawa; S. Kunimoto; T. Takeuchi; H. Umezawa; H. Ikezawa J. Antibiotics 1972 25 689-694
X-ray structure determination of 4-amino-3-hydroxy-6-methylheptanoic acid, an amine component of pepstatin. H. Nakamura; H.Morishima; T. Takita; H. Umezawa; Y. Iitaka J. Antibiotics 1973 26 255-256
Synthesis of 4-amino-3-hydroxy-6-methylheptanoic acid, an amine component of pepstatin. H. Morishima; T. Takita; H. Umezawa J. Antibiotics 1973 26 115-116
Inhibitory activity of pepstatin against acid protease and an estimation method of acid protease in gastric juice. (Japanese) T. Aoyagi; S. Kunimoto; T. Takeuchi; H. Umezawa Jap. J. Antibiotics 1973 26 109-114
New pepstatins, pepstatins BU, PR and AC produced by Streptomyces. T. Aoyagi; Y. Yagisawa; M. Kumagai; M. Hamada; H. Morishima; T. Takeuchi; H. Umezawa J. Antibiotics 1973 26 539-541
Hydroxypepstatin, a new pepstatin produced by Streptomyces. H. Umezawa; T. Miyano; T. Murakami; T. Takita; T. Aoyagi; T. Takeuchi; H. Naganawa; H. Morishima J. Antibiotics 1973 26 615-617
Fundamental studies on Pepstatin (Nos.1-4). Matsuzaki et al. Yakubutu Ryoho
Biosynthetic studies on pepstatin. Biosynthesis of (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid moiety. H. Morishima; T. Sawa; T. Takita; T. Aoyagi; T. Takeuchi; H. Umezawa J. Antibiotics 1974 27 267-273
Mechanism of inhibition of pepsin by pepstatin. II. S. Kunimoto; T. Aoyagi; R. Nishizawa; T. Komai; T. Takeuchi; H. Umezawa J. Antibiotics 1974 27 413-418
Enzymatic degradation of pepstatin A to a new tetrapeptide. H. Tone; N. Shibamoto; Y. Matsushita; T. Inui; A. Takamatsu; T. aoyagi; T. Takeuchi; H. Umezawa J. Antibiotics 1975 28 1009-1011
Purification and properties of pepstatin hydrolase from Bacillus sphaericus. H. Tone; Y. Matsushita; Y. Yagi; A. Takamatsu; T. Aoyagi; T. Takeuchi; H. Umezawa J. Antibiotics 1975 28 1012-1015
N-Acylated derivatives of a peptide obtianed by enzymatic degradation of pepstatins. Y. Matsushita; H. Tone; S. Hori; Y. Yagi; A. Takamatsu; H. Morishima; T. Aoyagi; T. Takeuchi; H.Umezawa J. Antibiotics 1975 28 1016-1018
The effects of lactoyl-pepstatin and the pspsin inhibitor peptide on pig cathepsin D. J. Kay; E.-G. Afting; T. Aoyagi; B-M. Dunn Biochemical Journal 1982 203 795-797