Compounds

Hydroxybenanomicin

Hydroxybenanomicin_1 Hydroxybenanomicin_2 Hydroxybenanomicin_3 Hydroxybenanomicin_4

Producing organism:

Actinomadura spadix MH193-16F4

Activity:

Antifungal

Clinical use:

-

Class no:

22 Reference(s)

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Title Author Journal Year Volume Page
New antifungal antibiotics, benanomicins A and B from an Actinomycete. T. Takeuchi; T. Hara; H. Naganawa; M. Okada; M. Hamada; H. Umezawa; S. Gomi; M. Sezaki; S. Kondo J. Antibiotics 1988 41 807-811
The structures of new antifungal antibiotics, benanomicins A and B. S. Gomi; M. Sezaki; S. Kondo; T. Hara; H. Naganawa; T. Takeuchi J. Antibiotics 1988 41 1019-1028
New antifungal antibiotics, benanomicins A and B inhibit infection of T-cell with human immunodeficiency virus (HIV) and syncytium formation by HIV. H. Hoshino; J. Seki; T. Takeuchi J. Antibiotics 1989 42 344-346
Biosynthesis of benanomicins. S. Gomi; M. Sezaki; M. Hamada; S. Kondo; T. Takeuchi J. Antibiotics 1989 42 1145-1150
Isolation of new minor benanomicins. S. Kondo; S. Gomi; K. Uotani; S. Inouye; T. Takeuchi J. Antibiotics 1991 44 123-129
Antifungal and antiviral activities of benanomicins and their analogues. S. Kondo; S. Gomi; D. Ikeda; M. Hamada; T. Takeuchi; H. Iwai; J. Seki; H. Hoshino J. Antibiotics 1991 44 1228-1236
A novel antifungal antibiotic, benanomicin A. H. Yamaguchi; S. Inouye; Y. Orikasa; H. Tohyama; K. Komuro; S. Gomi; S. Ohuchi; T. Matsumoto; M. Yamaguchi; T. Hiratani; K. Uchida; Y. Ohsumi; S. Kondo; T. Takeuchi Recent Progress in Antifungal Chemotherapy (Eds. H. Yamaguchi; G. S. Kobayashi; H. Takahashi)Marcel Dekker, Inc., New York/Basel/Hong Kong 1991 393-402
Amino acid analogs of benanomicin A through desalaninebenanomicin A. D. Ikeda; T. Nishizuka; S-P. Huang; S. Kondo; T. Takeuchi J. Antibiotics 1992 45 1645-1652
New hydroxybenanomicins produced by actinomadura. S. Kondo; S. Gomi; K. Uotani; S. Miyakawa; S. Inouye; D. Ikeda; T. Takeuchi Drugs Exptl. Clin. Res. 1992 18 217-224
Identification of strain MH193-16F4, a benanomicin-producing actinomycete, to Actinomadura spadix. N. Kinoshita; M. Okada; M. Hamada Actinomycetologica 1994 8 73-78
Successful treatment of Pneumocystis carinii pneumonia in mice with benanomicin A (ME1451). A. Yasuoka; S. Oka; K. Komuro; H. Shimizu; K. Kitada; Y. Nakamura; S. Shibahara; T. Takeuchi; S. Kondo; K. Shimada; S. Kimura Antimicorbial Agents and Chemotherapy 1995 39 720-724
Binding of benanomicin A to fungal cells in reference to its fungicidal action. M. Watanabe; S. Gomi; H. Tohyama; K. Ohtsuka; S. Shibahara; S. Inouye; H. Kobayashi; S. Suzuki; S. Kondo; T. Takeuchi; H. Yamaguchi J. Antibiotics 1996 49 366-373
Antifungal antibiotic benanomicin A increases susceptibility of Candida albicans to phagocytosis by murine macrophages. H. Watabe; T. Mikuniya; S. Inouye; S. Abe; H. Yamaguchi; S. Kondo; T. Takeuchi; T. W. Klein; H. Friedman; Y. Yamamoto J. Antibiotics 1996 49 1221-1225
The in-vitro activity of an antifungal antibiotic benanomicin A in comparison with amphotericin B. M. Watanabe; T. Hiratani; K. Uchida; K. Ohtsuka; H. Watabe; S. Inouye; S. Kondo; T. Takeuchi; H. Yamaguchi J. Antimicrobial Chemother. 1996 38 1073-1077
A synthetic approach to benanomicin A: Synthesis of the substituted 5,6-dihydrobenzo[a]naphthacenequinone. S. Hirosawa; T. Nishizuka; S. Kondo; D. Ikeda Chemistry Letters 1997 305-306
Synthesis of optically active α-tetralone: A key intermediate to natural benanomicinone. T. Nishizuka; S. Hirosawa; M. Tsushima; S. Kondo; D. Ikeda Chemistry Letters 1997 543-544
A synthetic approach to benanomicin A 1. Synthesis of 5,6-dihydrobenzo[a]naphthacenequinone. S. Hirosawa; T. Nishizuka; S. Kondo; D. Ikeda; T. Takeuchi J. Antibiotics 1997 50 685-689
A synthetic approach to benanomicin A. 2. Synthesis of the substituted 5,6-dihydrobenzo[a]naphthacenequinone. T. Nishizuka; S. Hirosawa; S. Kondo; D. Ikeda; T. Takeuchi J. Antibiotics 1997 50 755-764
Selective deoxygenation and O-methylation of benanomicin A: Synthesis of 9-deoxy-, 9-O-methyl- and 14-O-methylbenanomicin A. T. Nishizuka; S. Hirosawa; M. Hamada; S. Kondo; D. Ikeda; T. Takeuchi J. Antibiotics 1997 50 765-769
The in-vivo activity of an antifungal antibiotic, benanomicin A, in comparison with amphotericin B and fluconazole. K. Ohtsuka; M. Watanabe; Y. Orikasa; S. Inouye; K. Uchida; H. Yamaguchi; S. Kondo; T. Takeuchi J. Antimicrobial Chemotherapy 1997 39 71-77
Mode of antifungal action of benanomicin A in Saccharomyces cerevisiae. M. Watanabe; H. Tohyama; T. Hiratani; H. Watabe; S. Inouye; S. Kondo; T. Takeuchi; H. Yamaguchi J. Antibiotics 1997 50 1042-1051
Morphological alterations of Saccharomyces cerevisiae induced by benanomicin A, an antifungal antibiotic with mannan affinity. M. Watanabe; Y. Nishiyama; S. Inouye; H. Yamaguchi; S. Kondo; T. Takeuchi Microbiol. Immunol. 1998 42 365-370