Compounds

Amastatin

Amastatin_1

Producing organism:

Streptomyces sp.

Activity:

Aminopeptidase A inhibitor

Clinical use:

-

Class no:

5 Reference(s)

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Title Author Journal Year Volume Page
Amastatin, an inhibitor of aminopeptidase A, produced by Actinomycetes. T. Aoyagi; H. Tobe; F. Kojima; M. Hamada; T. Takeuchi; H. Umezawa J. Antibiotics 1978 31 636-638
Structure and chemical synthesis of amastatin. H. Tobe; H. Morishima; H. Naganawa; T. Takita; T. Aoyagi; H. Umezawa Agric. Biol. Chem. 1979 43 591-596
Purification by affinity chromatography using amastatin and properties of aminopeptidase A from pig kidney. H. Tobe; F. Kojima; T. Aoyagi; H. Umezawa Biochim. Biophys. Acta 1980 613 459-468
Synthesis and structure-activity relationships of amastatin analogues, inhibitors of aminopeptidase A. H. Tobe; H. Morishima; T. Aoyagi; H. Umezawa; K. Isshiki; K. Nakamura; T. Yoshioka; Y. Shimauchi; T. Inui Agric. Biol. Chem. 1982 46 1865-1872
Mitogenic potentials of bestatin, amastatin, arphamenines A and B, FK-156 and FK-565 on spleen lymphocytes. N. Weissmann; G. Leyhausen; A. Maidhof; W. Tanaka; H. Umezawa; W. E. G. Mueller J. Antibiotics 1985 38 772-778