Compounds

Erbstatin

Erbstatin_1

Producing organism:

Streptomyces No. NH435-hF3

Activity:

-

Clinical use:

-

Class no:

7 Reference(s)

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Title Author Journal Year Volume Page
Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3. H. Umezawa; M. Imoto; T. Sawa; K. Isshiki; N. Matsuda; T. Uchida; H. Iinuma; M. Hamada; T. Takeuchi J. Antibiotics 1986 39 170-173
The structure of an epidermal growth factor-receptor kinase inhibitor, erbstatin. H. Nakamura; Y. Iitaka; M. Imoto; K. Isshiki; H. Naganawa; T. Takeuchi; H. Umezawa J. Antibiotics 1986 39 170-173
The structure of an epidermal growth factor-receptor kinase inhibitor, erbstatin. H. Nakamura; Y. Iitaka; M. Imoto; K. Isshiki; H. Naganawa; T. Takeuchi; H. Umezawa J. Antibiotics 1986 39 314-315
Antitumor activity of erbstatin, a tyrosine protein kinase inhibitor. M. Imoto; K. Umezawa; K. Komuro; T. Sawa; T. Takeuchi; H. Umezawa Jpn. J. Cancer Res. (Gann) 1987 78 329-332
Effective synthesis of erbstatin and its analogs. K. Isshiki; M. Imoto; T. Takeuchi; H. Umezawa; T. Tsuchida; T. Yoshioka; K. Tatsuta J. Antibiotics 1987 40 1207-1208
Inhibition of tyrosine protein kinase by synthetic erbstatin analogs. K. Isshiki; M. Imoto; T. Sawa; K. Umezawa; T. Takeuchi; H. Umezawa; T. Tsuchida; T. Yoshioka; K. Tatsuta J. Antibiotics 1987 40 1209-1210
Kinetic studies of tyrosine kinase inhibition by erbstatin. M. Imoto; K. Umezawa; K. Isshiki; S. Kunimoto; T. Sawa; T. Takeuchi; H. Umezawa J. Antibiotics 1987 40 1471-1473
In situ inhibition of tyrosine protein kinase by erbstatin. M. Imoto; K. Umezawa; T. Sawa; T. Takeuchi; H. Umezawa Biochemistry International 1987 15 989-995