News
Feb. 2, 2018当研究室の熊谷直哉主席研究員が2017MBLA賞を受賞しました。
Dec. 14, 2017当研究室の渡辺匠部長が日本薬学会 学術振興賞を受賞しました。
Dec. 11, 2017当研究室のdioxaazatriborinane (B3NO2)がMolecules of the year (C&EN)にノミネートされました。
Feb. 1, 2017C&EN(2017年1月30日)、毎日新聞（2017年1月31日）、日経産業新聞（2017年1月31日）に当研究室の新規アミド化触媒が紹介されました。
Jun. 1, 2015新棟に引っ越しました。
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Recent publication
"Direct Catalytic Asymmetric Conjugate Addition of Benzofuran-3(2H)-Ones to α,β-Unsaturated Thioamides: Stereodivergent Synthesis of Rocaglaol"
Samanta, S.; Noda, H.; Watanabe, T.; Cui, J.; Shibasaki, M.
Angew. Chem. Int. Ed. 2024, 64, e202415805.
"Copper-Catalyzed Direct Asymmetric Aldol Reaction of Glycine Schiff Bases to Access syn-β-Hydroxy-α-amino Esters"
Takeuchi, T.; Shibasaki, M.
Org. Lett. 2024, 26, 7981.
"Catalytic Asymmetric Mannich-Type Reaction of α-Haloacetonitriles"
Saito, A.; Shibasaki, M.
Org. Lett. 2024, 26, 7546.
"Synthesis of Heteroaromatic-Fused Cyclic β-Amino Acids by Rhodium-Catalyzed Electrophilic Amination"
Manoharan, R.; Asada, Y.; Noda, H.; Shibasaki, M.
Synthesis 2024, 56, 1563.
"Direct Catalytic Enantioselective Conjugate Addition of α-Substituted Benzyl Nitriles to Alkyl Acrylates"
Samanta, S.; Cui, J.; Otsuka, Y.; Watanabe, T.; Shibasaki, M.
Org. Lett. 2024, 26, 2255.
"anti-Selective Synthesis of Substituted β-Homoprolines by Rhodium Alkyl Nitrene C–H Insertion"
Tang, X.; Noda, H.; Shibasaki, M.
Synlett 2023, eFirst.
"Examining the effects of additives and precursors on the reactivity of rhodium alkyl nitrenes generated from substituted hydroxylamines"
Noda, H.; Asada, Y.; Shibasaki, M.
Front. Chem. 2023, 11, 1271896.
"Catalytic Asymmetric Vinylogous Conjugate Addition of Butenolide to 2-Ester-Substituted Chromones: Access to Chiral Chromanone Lactones via Trapping of a Copper(I) Enolate by Trimethyl Borate"
Cui, J.; Oriez, R.; Samanta, S.; Noda, H.; Watanabe, T.; Shibasaki, M.
Org. Lett. 2023, 25, 8367.
"Locking the Conformation of a Paddlewheel Rhodium Complex: Design, Synthesis, and Applications in Catalytic Nitrene Transfers"
Tang, X.; Noda, H.; Shibasaki, M.
Angew. Chem. Int. Ed. 2023, 63, e202311027.
"Brønsted Base-Catalyzed Direct 1,6-Conjugate Addition of Butenolide to p-Quinone Methides"
Cui, J.; Samanta, S.; Watanabe, T.; Shibasaki, M.
Asian J. Org. Chem. 2023, 12, e202300176.
"Less Is More: N(BOH)2 Configuration Exhibits Higher Reactivity than the B3NO2 Heterocycle in Catalytic Dehydrative Amide Formation"
Opie, C. R.; Noda, H.; Shibasaki, M.; Kumagai, N.
Org. Lett. 2023, 25, 694.
"Asymmetric Syn-Selective Vinylogous Addition of Butenolides to Chromones via Al-Li-BINOL Catalysis"
Samanta, S.; Cui, J.; Noda, H.; Watanabe, T.; Shibasaki, M.
J. Org. Chem. 2023, 88, 1177.
"A Missing Link in Multisubstituted Pyrrolidines: Remote Stereocontrol Forged by Rhodium-Alkyl Nitrene"
Tang, X.; Tak, R. K.; Noda, H.; Shibasaki, M.
Angew. Chem. Int. Ed. 2022, 61, e202212421.
"Targeting the ATG5-ATG16L1 Protein-Protein Interaction with a Hydrocarbon-Stapled Peptide Derived from ATG16L1 for Autophagy Inhibition"
Cui, J.; Ogasawara, Y.; Kurata, I.; Matoba, K.; Fujioka, Y.; Noda, N. N.; Shibasaki, M; Watanabe, T.
J. Am. Chem. Soc. 2022, 144, 17671.
"Diastereoselective Direct Catalytic Asymmetric Mannich-Type Reactions of Alkylnitriles with a Ni(II)-Carbene Complex"
Adachi, S.; Saito, A.; Shibasaki, M.
Org. Lett. 2022, 24, 3901.
"Concise and Stereodivergent Approach to Chromanone Lactones through Copper-Catalyzed Asymmetric Vinylogous Addition of Siloxyfurans to 2-Ester-Substituted Chromones"
Cui, J.; Oriez, R.; Noda, H.; Watanabe, T.; Shibasaki, M.
Angew. Chem. Int. Ed. 2022, 61, e202203128. Selected as a inside back cover.
"Imbuing an Old Heterocycle with the Power of Modern Catalysis: An Isoxazolidin-5-one Story"
Noda, H.
Chem. Pharm. Bull. 2021, 69, 1160.
"Ligand-Enabled, Copper-Catalyzed Electrophilic Amination for the Asymmetric Synthesis of β-Amino Acids"
Tak, R. K.; Noda, H.; Shibasaki, M.
Org. Lett. 2021, 23, 8617. Highlighted in Synfacts 2022, 18, 216.
"Catalyst-Controlled Chemoselective Nitrene Transfers"
Noda, H.; Tang, X.; Shibasaki, M.
Helv. Chim. Acta 2021, 104, e2100140.
"Highly Enantio- and Diastereoselective Synthesis of 1,2,3-Trisubstituted Cyclopropanes from α,β-Unsaturated Amides and Stabilized Sulfur Ylides Catalyzed by a Chiral Copper(I) Complex"
Pagire, S. K.; Kumagai, N.; Shibasaki, M.
ACS Catal. 2021, 11, 11597.
"Strategic Synthesis of Asymmetrically Substituted C4N4 Fluorophores"
Xu, W.; Kohei, M.; Shibasaki, M.; Kumagai, N.
Synthesis 2021, 53, 3355.
"Generation and application of Cu-bound alkyl nitrenes for the catalyst-controlled synthesis of cyclic β-amino acids"
Tak, R. K.; Amemiya, F.; Noda, H.; Shibasaki, M.
Chem. Sci. 2021, 12, 7809. Highlighted in Synfacts 2021, 17, 945.
"Direct Catalytic Asymmetric Addition of Alkylnitriles to Aldehydes with Designed Nickel-Carbene Complexes"
Saito, A.; Adachi, S.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2021, 60, 8739. Highlighted in Synfacts 2021, 17, 521.
"特異なB3NO2組成6員環を有する複核ホウ素ヘテロ環の設計，合成，およびアミド化触媒への展開"
野田 秀俊，柴崎 正勝，熊谷 直哉
有機合成化学協会誌 2020, 78, 971.
"Catalytic Asymmetric Total Synthesis of Leucinostatin A"
Watanabe, T.; Abe, H.; Shibasaki, M.
Chem. Rec. 2021, 21, 175.