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Title Authors Journal Year Vol Pages
Structural view on autophagosome formation. N. N. Noda FEBS Letters 2024 598 84-106, doi:10.1002/1873-3468.14742
The UFM1 system: working principles cellular functions, and pathophysiology. M. Komatsu, T. Inada, and N. N. Noda Molecular Cell 2024 84 https://doi.org/10.1016/j.molcel.2023.11.034
In2Q2: a new entry of 16-membered tetraazamacrocycle concatenating indole and quinoline units. K. Kihara, T. Kobayashi, W. Xu, and N. Kumagai Chem. Eur. J 2024 30 doi.org/10.1002/chem.202304176
Protein phosphatase 2A inhibitor modulates natural killer cell homeostasis in peripheral tissues. Y. Shinzawa, S. Sasaki, S. Iwabuchi, S. Hashimoto, M. Kawada, and Y. Hayakawa Biochemical and Biophysical Research Communications 2024 741 151020, https://doi.org/10.1016/j.bbrc.2024.151020
A cancer-specific anti-podoplanin monoclonal antibody, PMab-117-mG2a exerts antitumor activities in human tumor xenograft models. T. Tanaka, H. Suzuki, T. Ohishi, M. K. Kaneko, and Y. Kato Cells 2024 13 1833, https://doi.org/10.3390/cells13221833
PP2A negatively regulates NK cell T-bet expression and anti-tumor effector function. Y. Shinzawa, D. Hara, Y. Shinguryo, S. Yokoyama, M. Kawada, and Y. Hayakawa Int Immunol. 2024 doi: 10.1093/intimm/dxae057. 
Thiazoplanomicin, a new thiazolyl peptide antibiotic from the leaf-litter actinomycete Actinoplanes sp. MM794L-181F6. Y. Takehana, H. Muramatsu, M. Hatano, Y. Ishizaki, M. Umekita, Y.Shibuya, C. Hayashi, T. Kimura, T. Takeuchi, K. Shimuta, R. Sawa, and M. Igarashi J. Antibiot. 2024 doi: 10.1038/s41429-024-00783-7.
Spencermartinsiella japonica f.a., sp. nov., a novel yeast species isolated from biofilm in a reverse osmosis system. H. Doi, A. Mishima, and R. Ikeda Mycoscience 2024 65 224-227, doi: 10.47371/mycosci.2024.05.004
Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock. J. Sun, Y. Zhang, J. Adams, C. Higgins, S. Kelly, H. Zhang, K. Cho, U. Johnson, B. Swarts, S. Wada, G. Patti, L. Shriver, B. Finck, E. Herzog, and B. DeBosch Cell Reports 2024 43 https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01216-6
Pyricularia oryzae enhances Streptomyces griseus growth via non-volatile alkaline metabolites. R. Sugita, T. Arazoe, T. Motoyama, H. Osada, T. Kamakura, K. Kuramochi, and Y. Furuyama Environmental Microbiology Reports 2024 16 e70012. https://doi.org/10.1111/1758-2229.70012
Direct catalytic asymmetric conjugate addition of benzofuran-3(2H)-ones to α,β-unsaturated thioamides: stereodivergent synthesis of rocaglaol. S. Samanta, H. Noda, T. Watanabe, J. Cui, and M. Shibasaki Angewandte Chemie International Edition 2024 e202415805. doi: 10.1002/anie.202415805.
Enhanced anticancer activity of 7MeERT over Ertredin: a comparative study on cancer cell proliferation and NDUFA12 binding. S. Atsumi, C. Nosaka, T. Onodera, H. Adachi, T. Watanabe, M. Kawada, M. Shibuya, S. I. Park, and H. J. Kwon Biomolecules 2024 14 1197. https://doi.org/10.3390/biom14091197
Antitumor activities of anti‑CD44 monoclonal antibodies in mouse xenograft models of esophageal cancer. K. Ishikawa, H. Suzuki, T. Ohishi, T. Nakamura, M. Yanaka, G. Li, T. Tanaka, A. Ohkoshi, M. Kawada, M. K. Kaneko, Y. Katori, and Y. Kato Oncol Rep. 2024 52 147. doi: 10.3892/or.2024.8806.
Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside. J. Tomono, K. Asano, T. Chiashi, M. Suzuki, M. Igarashi, Y. Takahashi, Y. Tanaka, and T. Yokoyama J. Biochem. 2024 175 587-598. doi: 10.1093/jb/mvae002.
Antiproliferative activities through accelerating autophagic flux by basidalin and its analogs in human cancer cells. T. Matagawa, Y. Sasazawa, K. Agui, M. Fujimaki, S. Kawano, A. Ogura, KI. Takao, M. Igarashi, and S. Simizu Bioorg Med Chem Lett. 2024 104 129713. doi: 10.1016/j.bmcl.2024.129713.
Synthesis and biochemical characterization of naphthoquinone derivatives targeting bacterial histidine kinases. T. Ishikawa, Y. Eguchi, M. Igarashi, T. Okajima, K. Mita, Y. Yamasaki, K. Sumikura, T. Okumura, Y. Tabuchi, C. Hayashi, M. Pasqua, M. Coluccia, G. Prosseda, B. Colonna, C. Kohayakawa, A. Tani, JI. Haruta, and R. Utsumi
J. Antibiot. 2024 77 522–532, https://doi.org/10.1038/s41429-024-00726-2
Impaired glycosylation of gastric mucins drives gastric tumorigenesis and serves as a novel therapeutic target. J. Arai, Y. Hayakawa, H. Tateno, K. Murakami, T. Hayashi, M. Hata, Y. Matsushita, H. Kinoshita, S. Abe, K. Kurokawa, Y. Oya, M. Tsuboi, S. Ihara, R. Niikura, N. Suzuki, Y. Iwata, T. Shiokawa, C. Shiomi, C. Uekura, K. Yamamoto, H. Fujiwara, S. Kawamura, H. Nakagawa, S. Mizuno, T. Kudo, S. Takahashi, T. Ushiku, Y. Hirata, C. Fujii, J. Nakayama, S. Shibata, S. Woods, D. L. Worthley, M. Hatakeyama, T. C. Wang, and M. Fujishiro Gastroenterology 2024 167 505-521, doi: 10.1053/j.gastro.2024.03.037.
Quality evaluation of gentamicin sulfate reference standards in Japanese Pharmacopoeia using hydrophilic Interaction chromatography combined with tandem mass spectrometry. K. Maekawa, R. Sawa, M. Matsui, T. Konda, Y. Kubota, A. Matsuo, A. Maeda, C. Takahashi, T. Tanimoto, Y. Nakagawa, S. Yoneda, Y. Mori, and S. Suzuki J AOAC Int. 2024 107 234-241. doi: 10.1093/jaoacint/qsad135.
Copper-catalyzed direct asymmetric aldol reaction of glycine Schiff bases to access syn-β-hydroxy-α-amino esters. T. Takeuchi and M. Shibasaki Org. Lett. 2024 26 7981-7986. https://doi.org/10.1021/acs.orglett.4c03085
Catalytic asymmetric Mannich-type reaction of α‑haloacetonitriles. A. Saito and M. Shibasaki Org. Lett. 2024 26 7546-7550. https://doi.org/10.1021/acs.orglett.4c02505
An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice. S. Tanaka, M. Kawakita, H. Yasui, K. Sudo, F. Itoh, M. Sasaki, N. Shibata, H. Hara, Y. Iwakura, T. Hashidate-Yoshida, H. Shindou, T. Shimizu, T. Oyama, H. Matsunaga, and K. Takahara Communications Biology 2024 7 782, https://doi.org/10.1038/s42003-024-06498-7
The role of lysophosphatidylcholine acyltransferase 2 in osteoblastic differentiation of C2C12 cells. S. Tabe, H. Hikiji, T. Hashidate-Yoshida, H. Shindou, T. Shimizu, and K. Tominaga FEBS Open Bio 2024 14 1490-1502, doi:10.1002/2211-5463.13845
Hepatocyte MMP14 mediates liver and inter-organ inflammatory responses to diet-induced liver injury. S. Kelly, C. Higgins, J. Sun, J. Adams, Y. Zhang, S. Ballentine, Y. Miao, X. Cui, M. Milewska, I. Wandzik, J. Yoshino, B. Swarts, S. Wada, and B. DeBosch PNAS Nexus 2024 3 357, https://doi.org/10.1093/pnasnexus/pgae357
Anti-CD44 variant 10 monoclonal antibody exerts antitumor activity in mouse xenograft models of oral squamous cell carcinomas. K. Ishikawa, H. Suzuki, T. Ohishi, G. Li, T. Tanaka, M. Kawada, A. Ohkoshi, M. K. Kaneko, and Y. Kato Int. J. Mol. Sci. 2024 25 9190, https://doi.org/10.3390/ijms25179190
Anti-HER2 cancer-specific mAb, H2Mab-250-hG1, possesses higher complement-dependent cytotoxicity than trastuzumab. H. Suzuki, T. Ohishi, T. Tanaka, M. K. Kaneko, and Y. Kato Int. J. Mol. Sci. 2024 25 8386, https://doi.org/10.3390/ijms25158386
Visualization of phospholipid synthesis on tissue sections using functional mass spectrometry imaging. T. Iwama, K. Kano, H. Kawana, H. Shindou, T. Shimizu, N. Kono, and J. Aoki Anal. Chem. 2024 96 11771-11779, https://doi.org/10.1021/acs.analchem.4c01219
A lipid index for risk of hyperlipidemia caused by anti-retroviral drugs. M. Shimura, N. H. Kuwata, A. Fujiwara, M. Taniguchi, T. Ichinose, F. Hamano, M. Uematsu, T. Inoue, S. Matsuyama, T. Suzuki, A. K. Ghosh, H. Shindou, T. Shimizu, and H. Mitsuya Antiviral Research 2024 223 105819, https://doi.org/10.1016/j.antiviral.2024.105819
NDUFA12 as a functional target of the anticancer compound Ertredin in human hepatoma cells as revealed by label-free chemical proteomics. S. I. Park, S. M. Cho, S. Atsumi, M. Kawada, M. Shibuya, J. Y. Lee, J. Y. Kim, and H. J. Kwon J. Proteome Res. 2024 23 130-141, doi: org/10.1021/acs.jproteome.3c00471
Reclassification of a reveromycin-producer and the proposals of Actinacidiphila reveromycinica sp. nov. and Actinacidiphila acidipaludis comb. nov. H. Komaki, H. Takagi, S. Takahashi, and H. Osada Biosci Biotechnol Biochem 2024 88 689-695, https://doi.org/10.1093/bbb/zbae032
Identification of a family of species-selective complex I inhibitors as potential anthelmintics. T. Davie, X. Serrat, L. Imhof, J. Snider, I. Sagljar, J. Keiser, H. Hirano, N. Watanabe, H. Osada, and A. G. Fraser Nat Commun. 2024 15 3367. https://doi.org/10.1038/s41467-024-47331-3
Macrophage/microglia-producing transient increase of platelet-activating factor is involved in neuropathic pain. S. Yamamoto, T. Hashidate-Yoshida, Y. Yoshinari, T. Shimizu, and H. Shindou iScience 2024 27 https://doi.org/10.1016/j.isci.2024.109466
Inhibition of kynurenine production by N, O-substituted hydroxylamine derivatives. M. Iijima, Y. Otsuka, S. Ohba, and I. Momose Bioorg. Med. Chem. Lett. 2024 106 129731, doi: 10.1016/j.bmcl.2024.129731.
Synthesis of heteroaromatic-fused cyclic β-amino acids by rhodium-catalyzed electrophilic amination. R. Manoharan, Y. Asada, H. Noda, and M. Shibasaki Synthesis 2024 56 1563-1575, DOI: 10.1055/a-2282-7450
Locally misfolded HER2 expressed on cancer cells is a promising target for development of cancer-specific antibodies. T. Arimori , E. Mihara, H. Suzuki, T. Ohishi, T. Tanaka, M. K. Kaneko, J.Takagi, and Y. Kato Structure 2024 32 536-549, https://doi.org/10.1016/j.str.2024.02.007
Direct catalytic enantioselective conjugate addition of α‑substituted benzyl nitriles to alkyl acrylates. S. Samanta, J. Cui, Y. Otsuka, T. Watanabe, and M. Shibasaki Org. Lett. 2024 26 2255-2259, https://doi.org/10.1021/acs.orglett.4c00427
Impact of perinatal maternal docosahexaenoic acid-containing phospholipid synthesis on offspring growth and neurological symptoms. A. Kanatani, D. Hishikawa, K. Nagata, F. Hamano. K. Nakano, T. Okamura, T. Shimizu, H. Shindou, T. Nagamatsu, and K. Yanagida bioRxiv 2024 https://doi.org/10.1101/2024.01.06.574487
Lysophospholipid acyltransferase 9 promotes emphysema formation via platelet-activating factor. H. Murano, S. Inoue, T. H. Yoshida, H. Shindou, T. Shimizu, Y. Otaki, Y. Minegishi, T. Kitaoka, M. Futakuchi, A. Igarashi, M. Nishiwaki, T. Nemoto, M. Sato, M. Kobayashi, K. Sato, T. Hanawa, O. Miyazaki, and M. Watanabe Am. J. Respir. Cell Mol. Biol. 2024 70 https://doi.org/10.1165/rcmb.2023-0253OC
Precursor-directed biosynthesis and biological activity of tripropeptin Cpip, a new tripropeptin C analog containing pipecolic acid. H. Hashizume, R. Sawa, Y. Kubota, S. Adachi, S. Harada, and M. Igarashi J. Antibiot. 2024 77 238-244, https://doi.org/10.1038/s41429-024-00703-9
Analysis of the valgamicin biosynthetic pathway reveals a general mechanism for cyclopropanol formation across diverse natural product scaffolds. R. F. Little, F. Trottmann, H. Hashizume, M. Preissler, S. Unger, R. Sawa, H. Kries, S. Pidot, M. Igarashi, and C. Hertweck ACS Chem. Biol. 2024 19 660-668, https://doi.org/10.1021/acschembio.3c00648
A cancer-specific monoclonal antibody against HER2 exerts antitumor activities in human breast cancer xenograft models. M. K. Kaneko., H. Suzuki, T. Ohishi, T. Nakamura, T. Tanaka, and Y. Kato Int. J. Mol. Sci. 2024 25 1941. doi: 10.3390/ijms25031941.
Catenulopyrizomicins, new anti-Hepatitis B virus compounds, from the rare actinomycete Catenuloplanes sp. MM782L-181F7. M. Yamasaki, R. Sawa, H. Muramatsu, Y. Yamamoto, M. Umekita, Y. Kubota, Y. Kanegae, and M. Igarashi J. Antibiot. 2024 77 85-92. doi: 10.1038/s41429-023-00681-4.
A cancer-specific monoclonal antibody against podocalyxin exerted antitumor activities in pancreatic cancer xenografts. H. Suzuki, T. Ohishi, T. Tanaka, M. K. Kaneko, and Y. Kato Int J. Mol. Sci. 2024 25 161. https://doi.org/10.3390/ijms25010161