生物系研究部第3生物活性研究部

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研究業績

Catenulopyrizomicins, new anti-Hepatitis B virus compounds, from the rare actinomycete Catenuloplanes sp. MM782L-181F7.
Yamasaki, M., Sawa, R., Muramatsu, H., Yamamoto, Y., Umekita, M., Kubota, Y., Kanegae, Y., Igarashi, M.
J. Antibiot. 77(2):85-92 (2024) [Abstract-PubMed]

Impact of the Helicobacter pylori Oncoprotein CagA in Gastric Carcinogenesis.
Hatakeyama, M.
Curr. Top. Microbiol. Immunol. 444:239-257 (2023) [Abstract-PubMed]

Comprehensive in virio structure probing analysis of the influenza A virus identifies functional RNA structures involved in viral genome replication.
Takizawa, N., Kawaguchi, R. K.
Comput. Struct. Biotechnol. J. 21:5259-5272 (2023) [Abstract-PubMed]

Coevolution of the ileum with Brk/Ptk6 family kinases confers robustness to ileal homeostasis.
Kikuchi, I., Iwashita, Y., Takahashi-Kanemitsu, A., Koebis, M., Aiba, A., Hatakeyama, M.
Bichem. Biophys. Res. Commun. 8:676:190-197 (2023) [Abstract-PubMed]

The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells.
Takahashi-Kanemitsu, A., Lu, M., Knight, C.T., Yamamoto, T., Hayashi, T., Mii, Y., Ooki, T., Kikuchi, I., Kikuchi, A., Barker, N., Susaki, E.A., Taira, M., Hatakeyama, M.
Sci. Signal. 16(794):eabp9020 (2023) [Abstract-PubMed] [プレスリリース(日本語)] [プレスリリース(英語)] [EurekAlert!記事] 日経バイオテク記事(2023-07-20)
[Free-access electric reprint]
本論文は7月18日刊行のScience Signaling誌(Vol 16, Issue 794)の表紙を飾りました!

Non-Helicobacter pylori gastric microbiome modulates prooncogenic responses and is associated with gastric cancer risk.
Niikura, R., Hayakawa, Y., Nagata, N., Miyoshi-Akiayama, T., Miyabayashi, K., Tsuboi, M., Suzuki, N., Hata, M., Arai, J., Kurokawa, K., Abe, S., Uekura, C., Miyoshi, K., Ihara, S., Hirata, Y., Yamada, A., Fujiwara, H., Ushiku, T., Woods, S.L., Worthley, D.L, Hatakeyama, M., Han, Y.W., Wang, T.C., Kawai, T. and Fujishiro, M.
Gastro Hep Adv. 220(8):e20221773 (2023) [Journal link]

Exploring Allosteric Inhibitors of Protein Tyrosine Phosphatases Through High-Throughput Screening.
Hayashi T., Hatakeyama, M.
Methods Mol. Biol. 2691:235-245 (2023) [Abstract-PubMed]

Diet-mediated constitutive induction of novel IL-4+ ILC2 cells maintains intestinal homeostasis in mice.
Cui, W., Nagano, Y., Morita, S., Tanoue, T., Yamane, Ishikawa, K., Sato, T., H., Kubo, M., Hori, S., Taniguchi, T., Hatakeyama, M., Atarashi, K. and Honda, K.
J. Exp. Med. 2(5):684-700 (2023) [Abstract-PubMed]

Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer.
Usui, Y., Taniyama, Y., Endo, M., Koyanagi, Y.N., Kasugai, Y., Oze, I., Ito, H., Imoto, I., Tanaka, T., Tajika, M., Niwa, Y., Iwasaki, Y., Aoi, T., Hakozaki, N., Takata, S., Suzuki, K., Terao, C., Hatakeyama, M., Hirata, M., Sugano, K., Yoshida, T., Kamatani, Y., Nakagawa, H., Matsuda, K., Murakami, Y., Spurdle, AB., Matsuo, K., Momozawa, Y.
New Eng. J. Med. 388(13):1181-1190 (2023) [Abstract-PubMed]

Azo-tagged C4N4 fluorophores: unusual overcrowded structures and their application to fluorescent imaging.
Kohei, M., Takizawa, N., Tsutsumi, R., Xu, W., Kumagai, N.
21(14):2889-2893 (2023) [Abstract-PubMed]

RNA Structure Determination by High-Throughput Structural Analysis.
Takizawa, N.
Methods Mol. Biol. 2586:217-231 (2023) [Abstract-PubMed]

Kinase Activity of PAR1b, Which Mediates Nuclear Translocation of the BRCA1 Tumor Suppressor, Is Potentiated by Nucleic Acid-Mediated PAR1b Multimerization
Nishikawa, H., Christiany, P., Hayashi, T., Iizasa, H., Yoshiyama, H., Hatakeyama, M.
Int. J. Mol. Sci. 23(12):6634 (2022) [Abstract-PubMed]

Transgenically expressed Helicobacter pylori CagA in vascular endothelial cells accelerates arteriosclerosis in mice
Tahmina, K., Hikawa, N., Takahashi-Kanemitsu, A., Knight, C.T., Sato, K., Itoh, F., Hatakeyama, M.
Biochem. Biophys. Res. Commun. 618:79-85 (2022) [Abstract-PubMed]

Helicobacter pylori-induced DNA double-stranded break in the development of gastric cancer
Murata-Kamiya, N., Hatakeyama, M.
Cancer Sci. 113(6):1909-1918 (2022) [Abstract-PubMed]

Mouse Gastric Epithelial Cells Resist CagA Delivery by the Helicobacter pylori Type IV Secretion System.
Shrestha, R., Murata-Kamiya, N., Imai, S., Yamamoto, M., Tsukamoto, T., Nomura, S., Hatakeyama, M.
Int. J. Mol. Sci. 23(5):2492 (2022) [Abstract-PubMed]

The H. pylori CagA Oncoprotein Induces DNA Double Strand Breaks through Fanconi Anemia Pathway Downregulation and Replication Fork Collapse.
Kolinjivadi, A.M., Sankar, H., Choudhary, R., Tay, L.S., Tan, T.Z., Murata-Kamiya, N., Voon,D.C.-C., Kappei, D., Hatakeyama, M., Krishnan, V., Ito, Y.
Int. J. Mol. Sci. 23(3):1661 (2022) [Abstract-PubMed]

A novel E198K substitution in the PA gene of influenza A virus with reduced susceptibility to baloxavir acid.
N. Takizawa and F. Momose
Arch. Virol., 2022, 1565-1570 (doi: 10.1007/s00705-022-05456-0)

Synthesis and antiviral activity of formycin derivatives with anti-influenza virus activity.
H. Takada, N. Takizawa, S. Shibasaki, H. Asaba, M. Igarashi, M. Shibasaki and Y. Takahashi
Bioorganic & Medicinal Chemistry, 2022, 57, https://doi.org/10.1016/j.bmc.2022.116613

Anti-influenza virus activity of methylthio-formycin distinct from that of T-705.
N. Takizawa, H. Takada, M. Umekita, M. Igarashi and Y. Takahashi
Front Microbiol. 2022, 13, 802671. doi: 10.3389/fmicb. 2022.802671

Helicobacter pylori CagA Elicits BRCAness To Induce Genome Instability That May Underlie Bacterial Gastric Carcinogenesis.
Imai, S., Ooki, T., Murata-Kamiya, N., Komura, D., Tahmina, K., Wu, W., Takahashi-Kanemitsu, A., Knight, C.T., Kunita, A., Suzuki, N., Tsuboi, M., Hata, M., Hayakawa, Y., Ohnishi, N., Ueda, K., Fukayama, M., Ushiku, T., Ishikawa, S., Hatakeyama, M.
Cell Host Microbe 29(6):941-958 (2021) [Abstract-PubMed]

Protocol for visualizing conditional interaction between transmembrane and cytoplasmic proteins.
Ooki, T., Hatakeyama, M.
STAR Protocols 2: 100430 (2021) [Abstract-PubMed]

Development of a Genetically Stable Live Attenuated Influenza Vaccine Strain using an Engineered High-Fidelity Viral Polymerase.
K. Mori, LR. Ohniwa, N. Takizawa, T. Naito and M. Saito
J. Virol., 2021, 95, e00493-21.

Acetophenone 4-nitrophenylhydrazone inhibits Hepatitis B virus replication by modulating capsid assembly.
M. Yamasaki, N. Matsuda, K. Matoba, S. Kondo, Y. Kanegae, I. Saito, and A. Nomoto
Virus Res., 306, 198565, 2021.

Alternative splicing reverses the cell-intrinsic and cell-extrinsic prooncogenic potentials of YAP1.
Ben, C., Wu, X., Takahashi-Kanemitsu, A., Knight, C.T., Hayashi, T., Hatakeyama, M.
J. Biol. Chem. 295(41): 13965-13980 (2020) [Abstract-PubMed]

Hyaluronan Degradation Promotes Cancer via Hippo-YAP Signaling: An Intervention Point for Cancer Therapy.
Ooki, T., Hatakeyama, M.
Bioessays, 42(7): e2000005 (2020) [Abstract-PubMed]

Helicobacter pylori CagA oncoprotein interacts with SHIP2 to increase its delivery into gastric epithelial cells.
Fujii, Y., Murata-Kamiya, N., Hatakeyama, M.
Cancer Sci. 111(5): 1596-1606 (2020) [Abstract-PubMed]

Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpins gastric carcinogenesis.
Takahashi-Kanemitsu, A., Knight, C.T., Hatakeyama, M.
Cell. Mol. Immunol. 17(1): 50-63 (2020) [Abstract-PubMed]

Interferon-induced transmembrane protein 1 (IFITM1) promotes distant metastasis of small cell lung cancer.
S. Sakamoto, H. Inoue, Y. Kohda, S. Ohba, T. Mizutani, and M. Kawada
Int. J. Mol. Sci., 2020, 21, 4934.

1α-25(OH)2D3 regulates agrin-induced acetylcholine receptor clustering through upregulation of rapsyn expression in C2C12 myotubes.
M. Arakawa and A. Wagatsuma.
Biochem. Biophys. Res. Commun., 2020, 525, 80-86.

Cobalt chloride, a chemical hypoxia-mimicking agent, suppresses myoblast differentiation by downregulating myogenin expression.
A.Wagatsuma, M. Arakawa, H. Matsumoto, R. Matsuda, T. Hoshino and K. Mabuchi
Mol. Cell. Biochem., 2020, 470, 199-214.

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori-Infected CAPZA1-Overexpressing Cells
Tsugawa, H., Kato, C., Mori, H., Matsuzaki, J., Kameyama, K., Saya, H., Hatakeyama, M., Suematsu, M., Suzuki, H.
Cell. Mol. Gastroenterol. Hepatol. 8(3): 319-334 (2019) [Abstract-PubMed]

Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer.
Yachida, S., Mizutani, S., Shiroma, H., Shiba, S., Nakajima, T., Sakamoto, T., Watanabe, H., Masuda, K., Nishimoto, Y., Kubo, M., Hosoda, F., Rokutan, H., Matsumoto, M., Takamaru, H., Yamada, M., Matsuda, T., Iwasaki, M., Yamaji, T., Yachida, T., Soga, T., Kurokawa, K., Toyoda, A., Ogura, Y., Hayashi, T., Hatakeyama, M., Nakagama, H., Saito, Y., Fukuda, S., Shibata, T., Yamada, T.
Nat. Med. 25(6): 968-76 (2019) [Abstract-PubMed]

Classification of Helicobacter pylori Virulence Factors: Is CagA a Toxin or Not?.
Knorr, J., Ricci, V., Hatakeyama, M., Backert, S.
Trends in Microbiol. 27(9): 731-8 (2019) [Abstract-PubMed]

High-molecular-weight hyaluronan is a Hippo pathway ligand that directs cell density-dependent growth inhibition via PAR1b.
Ooki, T., Murata-Kamiya, N., Takahashi-Kanemitsu, A., Wu, W. and Hatakeyama, M.
Dev. Cell 49(4): 590-604 (2019) [Abstract-PubMed]

Malignant Helicobacter pylori-Associated Diseases: Gastric Cancer and MALT Lymphoma.
Hatakeyama, M.
Adv. Exp. Med. Biol. 1-15 (2019) [Abstract-PubMed]

A C4N4 diaminopyrimidine fluorophore.
H. Noda, Y. Asada, T. Maruyama, N. Takizawa, NN. Noda, M. Shibasaki and N. Kumagai
Chem. Eur. J., 2019, 25, 4299-4304.

Flupyranochromene, a novel inhibitor of influenza virus cap-dependent endonuclease, from Penicillium sp. f28743
M. Yamasaki, M. Igarash, R. Sawa, C. Nosaka, M. Umekita, M. Hatano, T. Kimura, K. Iijima, N. Takizawa, T. Kato, K. Mizumoto, and A. Nomoto
J. Antibiot. 2019, 72, 125-133.

Local structural changes of the influenza A virus ribonucleoprotein complex by single mutations in the specific residues involved in efficient genome packaging.
N. Takizawa,Y. Ogura, Y. Fujita, T. Noda, H. Shigematsu, T. Hayashi and K. Kurokawa
Virology 2019, 531, 126-140.

Apical trafficking pathways of influenza A virus HA and NA via Rab17- and Rab23-positive compartments.
R. Sato, T. Okura, M. Kawahara, N. Takizawa, F. Momose and Y. Morikawa
Front. Microbiol., 2019, 10, 1857.

Evaluating the origin and virulence of a Helicobacter pylori cagA-positive strain isolated from a non-human primate.
Hashi, K., Imai, C., Yahara, K., Tahmina, K., Hayashi, T., Azuma, T., Miyabe-Nishiwaki, T., Sato, H., Matsuoka, M., Niimi, S., Okamoto, M., Hatakeyama, M.
Sci. Rep. 8(1), Article number: 15981 (2018) [Abstract-PubMed]

Transcriptional Co-activator Functions of YAP and TAZ Are Inversely Regulated by Tyrosine Phosphorylation Status of Parafibromin.
Tang, C., Takahashi-Kanemitsu, A., Kikuchi, I., Ben, C., Hatakeyama, M.
iScience 1: 1-15 (2018) [Abstract-PubMed]

A new biomarker candidate for spinal muscular atrophy : Identification of a peripheral blood cell population capable of monitoring the level of survival motor neuron protein.
N. Otsuki, R. Arakawa, K. Kaneko, R. Aoki, M. Arakawa and K. Saito
PLoS One 2018, 13(8), e0201764.

Translation of Hepatitis A virus IRES is upregulated by a hepatic cell-specific factor.
A. Sadahiro, A. Fukao, M. Kosaka, Y. Funakami, N. Takizawa, O. Takeuchi, K.E. Duncan and T. Fujiwara
Front. Geneti., 2018, 9, 307.

Current landscape and future prospects of antiviral drugs derived from microbial products.
N. Takizawa and M. Yamasaki
J. Antibiot. 2018, 71, 45-52.

Anti-influenza virus activity of a salcomine derivative mediated by inhibition of viral RNA synthesis.
N. Takizawa, T. Kimura, T. Watanabe and M. Shibasaki
Arch. Virol. 2018, 163, 1607-1614.

Differential mechanisms for SHP2 binding and activation are exploited by geographically distinct Helicobacter pylori CagA oncoproteins.
Hayashi, T., Senda, M., Suzuki, N., Nishikawa, H., Ben, C., Tang, C., Nagase, L., Inoue, K., Senda, T., Hatakeyama, M.
Cell Reports 20(12): 2876-90 (2017) [Abstract-PubMed]

Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer.
Hatakeyama, M.
Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 93(4): 196-219 (2017) [Abstract-PubMed]

Sequence Polymorphism and Intrinsic Structural Disorder as Related to Pathobiological Performance of the Helicobacter pylori CagA Oncoprotein.
Nishikawa, H., Hatakeyama, M.
Toxins 9(4), pii: E136 (2017) [Abstract-PubMed]

The enhanced expression of PKM2 is involved in the gastric cancer development via regulating cancer specific metabolism.
Shiroki, T., Yokoyama, M., Tanuma, N., Maejima, R., Tamai, K., Yamaguchi, K., Oikawa, T., Noguchi, T., Miura, K., Fujiya, T., Shima, H., Sato, I., Murata-Kamiya, N., Hatakeyama, M., Iijima, K., Shimosegawa, T., Satoh, K.
Cancer Sci. 108(5): 931-40 (2017) [Abstract-PubMed]

Efficient genome replication of hepatitis B virus using adenovirus vector: a compact pregenomic RNA-expression unit.
M. Suzuki, S. Kondo, M. Yamasaki, N. Matsuda, A. Nomoto, T. Suzuki, I. Saito and Y. Kanegae
Sci. Rep. 2017, 7:41851, doi: 10.1038/srep41851.

Generation of a Genetically Stable High-Fidelity Influenza Vaccine Strain.
T. Naito, K. Mori, H. Ushirogawa, N. Takizawa, E. Nobusawa, T. Odagiri, M. Tashiro, R. L. Ohniwa, K. Nagata, and M. Saito
J. Virol. 2017, 91, e01073-16.

Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagAphosphorylation in human duodenum carcinoma cell line AZ-521.
Nakano, M., Yahiro, K., Yamasaki, E., Kurazono, H., Akada, J., Yamaoka, Y., Niidome, T., Hatakeyama, M., Suzuki, H., Yamamoto, T., Moss, J., Isomoto, H., Hirayama, T.
Dis. Model. Mech. 9(12): 1473-81 (2016) [Abstract-PubMed]

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways.
Kikuchi, I., Takahashi-Kanemitsu, A., Sakiyama, N., Tang, C., Tang, P.J., Noda, S., Nakao, K., Kasai, H., Sato, T., Aiba, A., Hatakeyama, M.
Nat. Commun. 7, Article Number: 12887 (2016) [Abstract-PubMed]

Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b.
Nishikawa, H., Hayashi, T., Arisaka, F., Senda, T., Hatakeyama, M.
Sci. Rep. 6, Article Number: 30031 (2016) [Abstract-PubMed]

CEACAM6 is upregulated by Helicobacter pylori CagA and is a biomarker for early gastric cancer.
Roy, R.K., Hoppe, M.M., Srivastava, S., Samanta, A., Sharma, N., Tan, K.T., Yang, H., Voon, D.C., Pang, B., Teh, M., Murata-Kamiya, N., Hatakeyama, M., Chang, Y.T., Young, W.P., Ito, Y., Ho, K.Y., Tan, P., Soong, R., Koeffler, P.H., Yeoh, K.G., Jeyasekharan, A.D.
Oncotarget 7(34): 55290-301 (2016) [Abstract-PubMed]

Csk-mediated EPIYA phosphorylation of Pragmin creates a feed-forward Csk activation loop that promotes cell motility.
Senda, Y., Murata-Kamiya, N., Hatakeyama, M.
Cancer Sci. 107(7): 972-80 (2016) [Abstract-PubMed]

Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by Epstein-Barr virus.
Saju, P., Murata-Kamiya, N., Hayashi, T., Senda, Y., Nagase, L., Noda, S., Matsusaka, K., Funata, S., Kunita, A., Urabe, M., Seto, Y., Fukayama, M., Kaneda, A., Hatakeyama, M.
Nat. Microbiol. Article number: 16026 (2016) [Abstract-PubMed] [Nature Microbiology, News & Views]

The Helicobacter pylori cytotoxin CagA is essential for suppressing host heat shock protein expression.
Lang, B.J., Gorrell, R.J., Tafreshi, M., Hatakeyama, M., Kwok, T., Price, J.T.
Cell Stress Chaperones 21(3): 523-33 (2016) [Abstract-PubMed]

Helicobacter pylori induces IL-1β protein through the inflammasome activation in differentiated macrophagic cells.
Kameoka, S., Kameyama, T., Hayashi, T., Seto, S., Ohnishi, N., Hayashi, T., Murata-Kamiya, N., Higashi, H., Hatakeyama, M., Takaoka, A.
Biomed. Res. 37(1): 21-27 (2016) [Abstract-PubMed]

Use of multiple cryoprotectants to improve diffraction quality from protein crystals.
Senda, M., Hayashi, T., Hatakeyama, M., Takeuchi, K., Sasaki, A.T., Senda, T.
Cryst. Growth Des. 16(3): 1565-71 (2016) [ACS Publications]

Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA.
Shimoda, A., Ueda, K., Murata-Kamiya, N., Mukai, S., Sawada, S., Azuma, T., *Hatakeyama, M., *Akiyoshi, K.
Sci. Rep. 6: 18346 (2016) [Abstract-PubMed] (*Corresponding authors)

Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling.
Noda, S., Takahashi, A., Hayashi, T., Tanuma, S. and Hatakeyama, M.
Biochem. Biophys. Res. Commun. 469(4): 1133-9 (2016) [Abstract-PubMed]

Imaging flow cytometry analysis to identify differences of survival motor neuron protein expression in patients with spinal muscular atrophy.
R. Arakawa, M. Arakawa, K. Kaneko, N. Otsuki, R. Aoki and K. Saito.
Pediatr. Neurol. 2016, 61, 70-75.

Influenza a virus hemagglutinin is required for the assembly of viral components including bundled vRNPs at the lipid raft.
N. Takizawa, F. Momose, Y. Morikawa and A. Nomoto.
Viruses 2016, 8, 249

Short intracellular HIV-1 transcripts as biomarkers of residual immune activation in patients on antiretroviral therapy.
A. Ishizaka, H. Sato, H. Nakamura, M. Koga, T. Kikuchi, N. Hosoya, T.Koibuchi, A. Nomoto, A. Kawana-Tachikawa and T. Mizutani
J. Virol. 2016, 90, 5665-5676.

Transferrin Receptor 1 Facilitates Poliovirus Permeation of Mouse
Brain Capillary Endothelial Cells.
T. Mizutani, A. Ishizaka and C. Nihei.
J. Biol. Chem. 2016, 291, 2829-2836.

Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis.
Nagase, L., Hayashi, T., Senda, T. and Hatakeyama, M.
Sci. Rep. 5: 15749 (2015) [Abstract-PubMed]

Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein.
Suzuki, N., Murata-Kamiya, N., Yanagiya, K., Suda, W., Hattori, M., Kaneda, H., Bingo, A., Fujii, Y., Maeda, S., Koike, K. and Hatakeyama, M.
Sci. Rep. 5: 10024 (2015) [Abstract-PubMed]

The werner protein acts as a coactivator of NF-κB on HIV-1 and IL-8 promoters.
T. Mizutani, A. Ishizaka and Y. Furuichi
J. Biol. Chem. 2015, 290, 18391-18399

Helicobacter pylori CagA and Gastric Cancer: A Paradigm for Hit-and-Run Carcinogenesis.
Hatakeyama, M.
Cell Host Microbe 15(3): 306-16 (2014) [Abstract-PubMed]

Helicobacter pylori generates cells with cancer stem cell properties via epithelial-mesenchymal transition-like changes.
Bessède, E., Staedel, C., Acuña Amador, L.A., Nguyen, P.H., Chambonnier, L., Hatakeyama, M., Belleannée, G., Mégraud, F., Varon, C.
Oncogene 33: 4123-31 (2014) [Abstract-PubMed]

A natural variant of the Helicobacter pylori CagA oncoprotiein that lost the ability to interact with PAR1.
Hashi, K., Murata-Kamiya, N., Varon, C., Megraud, F., Domiguez-Bello, M.G., Hatakeyama, M.
Cancer Sci. 105(3): 245-51 (2014) [Abstract-PubMed]

A novel evaluation method of survival motor neuron protein as a biomarker of spinal muscular atrophy by imaging flow cytometry.
M. Arakawa, R. Arakawa, S. Tatsumi, R. Aoki, K. Saito and A. Nomoto.
Biochem. Biophys. Res. Commun. 2014, 453, 368-374.

All-atom molecular dynamics calculation study of entire pollovirus empty capsids in solution.
Y. Andoh, N. Yoshii, A. Yamada, K. Fujimoto, H. Kojima, K. Mizutani, A. Nakagawa,
A. Nomoto and S. Okazaki.
J. Chem. Phys. 2014, 141, 165101.

Suppression of hepatitis C virus replication by cyclin-dependent Kinase inhibitors.
T. Munakata, M. Inada, Y. Tokunaga, T. Wakita, M. Kohara and A. Nomoto.
Antivir. Res. 2014, 108, 79-87.

7SK small nuclear ribonucleoprotein complex is recruited to the HIV-1 promoter via short viral transcripts.
T. Mizutani, A. Ishizaka, Y. Suzuki and H. Iba.
FEBS Lett. 2014, 588, 1630-1636.

YAP and TAZ, Hippo signaling targets, act as a rheostat for nuclear SHP2 function.
Tsutsumi, R., Masoudi, M., Takahashi, A., Fujii, Y., Hayashi, T., Kikuchi, I., Satou, Y., Taira, M., and Hatakeyama, M.
Dev. Cell 26(6): 658-65 (2013) [Abstract-PubMed][ライフサイエンス新着論文レビュー]

Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase.
Miura, K., Wakayama, Y., Tanino, M., Orba, Y., Sawa, H., Hatakeyama, M., Tanaka, S., Sabe, H., and Mochizuki, N.
Oncogene 32(45): 5292-301 (2013) [Abstract-PubMed]

Bacterial EPIYA effectors - Where do they come from? What are they? Where are they going?
Hayashi, T., Morohashi, H., and Hatakeyama, M.
Cell. Microbiol. 15(3): 377-85 (2013) [Abstract-PubMed]

PAR1b takes the stage in the morphogenetic and motogenetic activity of Helicobacter pylori CagA oncoprotein.
Yamahashi, Y. and Hatakeyama, M.
Cell Adh. Migr.7(1): 11-17 (2013) [Abstract-PubMed]

Structural insights into the recruitment of SMRT by the corepressor SHARP under phosphorylative regulation.
S. Mikami, T. Kanaba, N. Takizawa, A. Kobayashi, R. Maesaki, T. Fujiwara, Y. Ito and M. Mishima.
Structure 2013, 22, 1-12.

The essential role for the RNA triphosphatase Cet1p in nuclear import of the mRNA capping enzyme Cet1p-Ceg1p complex of Saccharomyces cerevisiae.
N. Takizawa, T. Fujiwara, M. Yamasaki, A. Saito, A. Fukao, A. Nomoto and K. Mizumoto.
PLOS ONE 2013, 8, e 78000.

Structure of the second RRM domain of Nrd1, a fission yeast MAPK target RNA binding protein, and implication for its RNA recognition and regulation.
A. Kobayashi, T. Kanaba, R. Satoh, T. Fujiwara, Y. Ito, R. Sugiura and M. Mishima.
Biochem. Biophys. Res. Commun. 2013, 437, 12-17.

Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells.
Tsugawa, H., Suzuki, H. Seya, H., Hatakeyama, M., Hirayama, T., Hirata, K., Nagano, O., Matsuzaki, J., and Hibi, T.
Cell Host Microbe 12(6): 764-77 (2012) [Abstract-PubMed]

CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemnes-associated reprogramming factors SALL4 and KLF5.
Fujii, Y., Yoshihashi, K., Suzuki, H., Tsutsumi, S., Mutoh, H., Maeda, S., Yamagata, Y., Seto, Y., Aburatani, H., and Hatakeyama, M.
Proc. Natl. Acad. Sci. U. S. A. 109: 20584-9 (2012)[Abstract-PubMed]

Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of Helicobacter pylori oncogenic effector CagA.
Hayashi, T., Senda, M., Morohashi, H., Higashi, H., Horio, M., Kashiba, Y., Nagase, L., Sasaya, D., Shimizu, T., Venugopalan, N., Kumeta, H., Noda, N.N., Inagaki, F., Senda, T., and Hatakeyama, M.
Cell Host Microbe 12(1): 20-33 (2012) [Abstract-PubMed] [Preview by Backert and Tegtmeyer][ライフサイエンス新着論文レビュー]

Helicobacter pylori CagA Triggers Expression of the Bactericidal Lectin REG3γ via Gastric STAT3 Activation.
Lee, K. S., Kalantzis, A., Jackson, C. B., O'Connor. L., Murata-Kamiya, N., Hatakeyama, M., Judd, L. M., Giraud, A. S., Menheniott, T. R.
PLoS One 7(2): e30786 (2012) [Abstract-PubMed]

Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling.
Kikuchi, K., Murata-Kamiya, N., Kondo, S., Hatakeyama, M.
Microbes Infect. 14(5): 470-6 (2012) [Abstract-PubMed]

Amycolamicin: a novel broad-spectrum antibiotic inhibiting bacterial topoisomerase.
R. Sawa, Y. Takahashi, H. Hashizume, K. Sasaki, Y. Ishizaki, M.Umekita, M. Hatano, H. Abe, T. Watanabe, N. Kinoshita, Y. Homma, C. Hayashi, K. Inoue, S. Ohba, T. Masuda, M. Arakawa, Y. Kobayashi, M. Hamada, M. Igarashi, H. Adachi, Y. Nishimura and Y. Akamatsu.
Chem. Eur. J. 2012, 18, 15772-15781.

HSC90 is required for nascent hepatitis C virus core protein stability in yeast cells.
N. Kubota, Y. Inayoshi, N. Satoh, T. Fukuda, K. Iwai, H. Tomoda, M. Kohara, K. Kataoka, A. Shimamoto, Y. Furuichi, A. Nomoto, A. Naganuma and S. Kuge.
FEBS Lett. 2012, 586, 2318-2325.

Poliovirus trafficking toward central nervous system via human poliovirus receptor-dependent and -independent pathway.
S. Ohka, C. Nihei, M. Yamazaki and A. Nomoto.
Frontiers in Microbiology 2012, 3, 1-5.

RNA 結合タンパク質による翻訳制御
藤原俊伸
細胞工学「神経形の翻訳制御メカニズム」 2012, 31, 646-654.

The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation.
I. Tanida, M. Yamasaki, M. Komatsu and T. Ueno.
Autophagy 2012, 8, 88-97.

Human first-trimester chorionic villi have a myogenic potential.
R. Arakawa, R. Aoki, M. Arakawa and K. Saito.
Cell Tissue Res. 2012, 348, 189-197.

Functional and direct interaction between the RNA binding protein HuD and active Akt1.
T. Fujiwara, A. Fukao, Y. Sasano, H. Matsuzaki, U. Kikkawa, H. Imataka, K. Inoue, S. Endo, N. Sonenberg, C. Thoma and H. Sakamoto.
Nucleic Acids Res. 2012, 40, 1944-1953.

Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF-kappaB RelA/p50 heterodimer.
A. Ishizaka, T. Mizutani, K. Kobayashi, T. Tando, K. Sakurai, T. Fujiwara and H. Iba.
J. Biol. Chem. 2012, 287, 11924-11933.

Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish.
Y. Mishima, A. Fukao, T. Kishimoto, H. Sakamoto, T. Fujiwara and K. Inoue.
Proc. Natl. Acad. Sci. USA 2012, 109, 1104-1109.

Polarity-regulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1) to regulate RhoA-dependent actin cytoskeletal reorganization.
Yamahashi, Y., Saito, Y., Murata-Kamiya, N., Hatakeyama, M.
J. Biol. Chem. 286(52): 44576-84 (2011) [Abstract-PubMed]

Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors.
Safari, F., Murata-Kamiya, N., Saito, Y., Hatakeyama, M.
Proc. Natl. Acad. Sci. U. S. A. 108(36): 14938-43 (2011) [Abstract-PubMed]

Evolution of cagA Oncogene of Helicobacter pylori through Recombination.
Furuta, Y., Yahara, K., Hatakeyama, M., Kobayashi I.
PLoS One 6(8): e23499 (2011) [Abstract-PubMed]

Potentiation of Helicobacter pylori CagA virulence through homodimerization.
Nagase, L., Murata-Kamiya, N., Hatakeyama, M.
J. Biol. Chem., 286(38): 33622-31 (2011) [Abstract-PubMed]

Pathophysiological functions of the CagA oncoprotein during infection by Helicobacter pylori.
Murata-Kamiya, N.
Microbes Infect. 13(10): 799-807 (2011) [Abstract-PubMed]

SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver.
Takahashi, A., Tsutsumi, R., Kikuchi, I., Obuse, C., Saito, Y., Seidi, A., Karisch, R., Fernandez, M., Cho, T., Ohnishi, N., Rozenblatt-Rosen, O., Meyerson, M., Neel, B.G., Hatakeyama, M.
Mol. Cell 43(1): 45-56 (2011) [Abstract-PubMed] [ライフサイエンス新着論文レビュー][CANCER DISCOVERY@AACR]

Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoprotein.
Hatakeyama, M.
Cancer Sci. 102(1): 36-43 (2011) [Abstract-PubMed]

ポリオ感染の分子機構から根絶まで
野本明男
感染・炎症・免疫 2011, 41, 42-53.

Small subunit processome、核小体タンパク質フィブリラリン
牛田千里、藤原俊伸
生体の科学「細胞核 - 構造と機能」 2011, 62, 418-421.

発生・分化と翻訳制御-RNA結合蛋白質がつかさどる高次生命現象
深尾亜喜良、藤原俊伸
医学のあゆみ「RNA医学・医療」 2011, 238, 418-425.

Development of recombinant hepatitis C virus with NS5A from strains of genotypes 1 and 2.
Y. Okamoto, T. Masaki, A. Murayama, T. Munakata, A. Nomoto, S. Nakamoto, O. Yokosuka, H. Watanabe, T. Wakita, and T. Kato.
Biochem. Biophys. Res. Commun. 2011, 410, 04-409.

Mechanisms of translational regulation by a human eIF5-mimic protein.
C. R. Singh, R. Watanabe, D. Zhou, M. D. Jennings, A. Fukao, B. Lee, Y. Ikeda, J. A. Chiorini, S. G. Campbell, M. P. Ashe, T. Fujiwara, R. C. Wek, G. D. Pavitt and K. Asano.
Nucleic Acids Res. 2011, 39, 8314-8328.

Dynamic profiling of mRNA turnover reveals gene-specific and system-wide regulation of mRNA decay.
S. E. Munchel, R. K. Shultzaberger, N. Takizawa and K. Weis.
Mol. Biol. Cell 2011, 22, 2787-2795.

Crucial role of the influenza virus NS2 (NEP) C-terminal domain in M1 binding and nuclear export of vRNP.
T. Shimizu, N. Takizawa, K. Watanabe, K. Nagata and N. Kobayashi.
FEBS Lett. 2011, 585, 41-46.

Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21.
Saito, Y., Murata-Kamiya, N., Hirayama, T., Ohba, Y., Hatakeyama, M.
J. Exp. Med. 207(10): 2157-2174 (2010) [Abstract-PubMed]

Helicobacter pylori Exploits Host Membrane Phosphatidylserine for Delivery, Localization, and Pathophysiological Action of the CagA Oncoprotein.
Murata-Kamiya, N., Kikuchi, K., Hayashi, T., Higashi, H., Hatakeyama, M.
Cell Host Microbe 7(5): 399-411 (2010) [Abstract-PubMed]

Helicobacter pylori infection, oncogenic pathways and epigenetic mechanisms in gastric carcinogenesis.
Ding, S.Z., Goldberg, J.B., Hatakeyama, M.
Future Oncol. 6(5): 851-62 (2010) [Abstract-PubMed]

Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis.
Ding, S.Z., Fischer, W., Kaparakis-Liaskos, M., Liechti, G., Merrell, D.S., Grant, P.A., Ferrero, R.L., Crowe, S.E., Haas, R., Hatakeyama, M., Goldberg, J.B.
PLoS One 1;5(4): e9875 (2010) [Abstract-PubMed]

The CagA protein of Helicobacter pylori suppresses the functions of dendritic cell in mice.
Tanaka, H., Yoshida, M., Nishiumi, S., Ohnishi, N., Kobayashi, K., Yamamoto, K., Fujita, T., Hatakeyama, M., Azuma, T.
Arch. Biochem. Biophys. 498(1): 35-42 (2010) [Abstract-PubMed]

Sorting of influenza A virus RNA genome segments after nuclear export.
N. Takizawa, M. Kumakura, K. Takeuchi, N. Kobayashi and K. Nagata.
Virology 2010, 401, 248-256.

Poliomyelitis.
S. Koike and A. Nomoto.
The Picornaviruses 2010, 339-351.

2A protease is not a prerequisite for poliovirus replication.
H. Igarashi, Y. Yoshino, M. Miyazawa, H. Horie, S. Ohka and A. Nomoto.
J. Virol. 2010, 84, 5947-5957.

Involvement of vesicular trafficking system in membrane targeting of the progeny influenza virus genome.
S. Jo, A. Kawaguchi, N. Takizawa, Y. Morikawa, F. Momose and K. Nagata.
Microbes Infect. 2010, 12, 1079-1084.

Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination.
Lamb, A., Yang, X.D., Tsang, Y.H., Li, J.D., Higashi, H., Hatakeyama, M., Peek, R.M., Blanke, S.R., Chen, L.F.
EMBO Rep. 10(11):1242-9 (2009) [Abstract-PubMed]

Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice.
Miura, M., Ohnishi, N., Tanaka, S., Yanagiya, K. and Hatakeyama, M.
Int. J. Cancer 125(11): 2497-504 (2009) [Abstract-PubMed]

Stability of Helicobacter pylori CagA oncoprotein in human gastric epithelial cells.
Ishikawa, S., Ohta, T. and Hatakeyama, M.
FEBS Letters 583(14): 2414-8 (2009) [Abstract-PubMed]

Role of PAR1/MARK kinases in the morphogenetic activity of Helicobacter pylori CagA.
Lu, H., Murata-Kamiya, N., Saito, Y. and Hatakeyama, M.
J. Biol Chem. 284(34): 23024-36 (2009) [Abstract-PubMed]

Helicobacter pylori CagA causes mitotic impairment and induces chromosomal instability.
Umeda, M., Murata-Kamiya, N., Saito Y., Ohba, Y., Takahashi, M. and Hatakeyama, M.
J. Biol. Chem. 284(33): 22166-72 (2009) [Abstract-PubMed]

Helicobacter pylori and gastric carcinogenesis.
Hatakeyama M.
J. Gastroenterol 44(4): 239-48 (2009) [Abstract-PubMed]

Distribution of Kakugo virus and its effects on the gene expression profile in the brain of the worker honeybee Apis mellifera L.
T. Fujiyuki, E. Matsuzaka, T. Nakaoka, H. Takeuchi, A. Wakamoto, S. Ohka, K. Sekimizu, A. Nomoto and T. Kubo.
J. Virol. 2009, 83, 11560-11568.

Receptor-dependent and -independent axonal retrograde transport of poliovirus in motor neurons.
S. Ohka, M. Sakai, S. Bohnert, H. Igarashi, K. Deinhardt, G. Schiavo and A. Nomoto.
J. Virol. 2009, 83, 4995-5004.

Induction of immune responses to a human immunodeficiency virus type 1 epitope by novel chimeric influenza viruses.
N. Takizawa, M. Morita, K. Adachi, K. Watanabe and N. Kobayashi.
Drug Discov. Ther. 2009, 3, 252-259.

Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA.
Hatakeyama M.
Oncogene 27(55): 7047-54 (2008) [Abstract-PubMed]

Structural and functional diversity in the PAR1b/MARK2-binding region of Helicobacter pylori CagA.
Lu HS, Saito Y, Umeda M, Murata-Kamiya N, Zhang HM, Higashi H, Hatakeyama M.
Cancer Sci. 99(10): 2004-11 (2008) [Abstract-PubMed]

Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway.
Nakayama, M., Hisatsune, J., Yamasaki, E., Isomoto, H., Kurazono, H., Hatakeyama, M., Azuma, T., Yamaoka, Y., Yahiro, K., Moss, J., Hirayama, T.
J. Biol. Chem. 284(3): 1612-9 (2008) [Abstract-PubMed]

Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation.
Nakajima, J., Ishikawa, S., Hamada, JI., Yanagihara, M., Koike, T., Hatakeyama, M.
Biochem. Biophys. Res. Commun. 370(1): 189-94 (2008) [Abstract-PubMed]

SagA of CagA in Helicobacter pylori pathogenesis.
Hatakeyama, M.
Curr. Opin. Microbiol. 11(1): 30-7 (2008) [Abstract-PubMed]

Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors.
Miyamoto, D., Miyamoto, M., Takahashi, A., Yomogita, Y., Higashi, H., Kondo, S., Hatakeyama, M.
Oncogene 27(25): 3508-15 (2008) [Abstract-PubMed]

Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse.
Ohnishi, N., Yuasa, H., Tanaka, S., Sawa, H., Miura, M., Matsui, A., Higashi, H., Musashi, M., Iwabuchi, K., Suzuki, M., Yamada, G., Azuma, T., Hatakeyama, M.
Proc. Natl. Acad. Sci. U. S. A. 105(3): 1003-8 (2008) [Abstract-PubMed]

Deregulation of beta-catenin signal by Helicobacter pylori CagA requires the CagA-multimerization sequence.
Kurashima, Y., Murata-Kamiya, N., Kikuchi, K., Higashi, H., Azuma, T., Kondo, S., Hatakeyama, M.
Int J Cancer 122(4): 823-31 (2008) [Abstract-PubMed]

Comparative aspects on the role of polypyrimidine tract-binding protein in internal initiation of hepatitis C virus and picornavirus RNAs.
T. Nishimura, M. Saito, T. Takano, A. Nomoto, M. Kohara and K. Tsukiyama-Kohara.
Comp. Immunol. Microbiol. Infect. Dis. 2008, 31, 435-448.

Efficient propagation of betanodavirus in a murine astrocytoma cell line.
N. Takizawa, K. Adachi, T. Ichinose and N. Kobayashi.
Virus Res. 2008, 136, 206-210.

Establishment of reverse genetics system of betanodavirus for the efficient recovery of infectious particles.
N. Takizawa, K. Adachi and N. Kobayashi.
J. Virol. Methods 2008, 151, 271-276.

Hsc70 regulates the nuclear export but not the import of influenza viral RNP: A possible target for the development of anti-influenza virus drugs.
K. Watanabe, N. Takizawa, S. Noda, F. Tsukahara, Y. Maru and N. Kobayashi.
Drug Discov. Ther. 2008, 2, 77-84.

※前所属での業績も含む、2008年以降
*The papers published in previous lab are included.

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