生物系研究部第3生物活性研究部

研究業績

A novel E198K substitution in the PA gene of influenza A virus with reduced susceptibility to baloxavir acid.
N. Takizawa and F. Momose
Arch. Virol., 2022, 1565-1570 (doi: 10.1007/s00705-022-05456-0)

Synthesis and antiviral activity of formycin derivatives with anti-influenza virus activity.
H. Takada, N. Takizawa, S. Shibasaki, H. Asaba, M. Igarashi, M. Shibasaki and Y. Takahashi
Bioorganic & Medicinal Chemistry, 2022, 57, https://doi.org/10.1016/j.bmc.2022.116613

Anti-influenza virus activity of methylthio-formycin distinct from that of T-705.
N. Takizawa, H. Takada, M. Umekita, M. Igarashi and Y. Takahashi
Front Microbiol. 2022, 13, 802671. doi: 10.3389/fmicb. 2022.802671

Development of a Genetically Stable Live Attenuated Influenza Vaccine Strain using an Engineered High-Fidelity Viral Polymerase.
K. Mori, LR. Ohniwa, N. Takizawa, T. Naito and M. Saito
J. Virol., 2021, 95, e00493-21.

Acetophenone 4-nitrophenylhydrazone inhibits Hepatitis B virus replication by modulating capsid assembly.
M. Yamasaki, N. Matsuda, K. Matoba, S. Kondo, Y. Kanegae, I. Saito, and A. Nomoto
Virus Res., 306, 198565, 2021.

Interferon-induced transmembrane protein 1 (IFITM1) promotes distant metastasis of small cell lung cancer.
S. Sakamoto, H. Inoue, Y. Kohda, S. Ohba, T. Mizutani, and M. Kawada
Int. J. Mol. Sci., 2020, 21, 4934.

1α-25(OH)2D3 regulates agrin-induced acetylcholine receptor clustering through upregulation of rapsyn expression in C2C12 myotubes.
M. Arakawa and A. Wagatsuma.
Biochem. Biophys. Res. Commun., 2020, 525, 80-86.

Cobalt chloride, a chemical hypoxia-mimicking agent, suppresses myoblast differentiation by downregulating myogenin expression.
A.Wagatsuma, M. Arakawa, H. Matsumoto, R. Matsuda, T. Hoshino and K. Mabuchi
Mol. Cell. Biochem., 2020, 470, 199-214.

A C4N4 diaminopyrimidine fluorophore.
H. Noda, Y. Asada, T. Maruyama, N. Takizawa, NN. Noda, M. Shibasaki and N. Kumagai
Chem. Eur. J., 2019, 25, 4299-4304.

Flupyranochromene, a novel inhibitor of influenza virus cap-dependent endonuclease, from Penicillium sp. f28743
M. Yamasaki, M. Igarash, R. Sawa, C. Nosaka, M. Umekita, M. Hatano, T. Kimura, K. Iijima, N. Takizawa, T. Kato, K. Mizumoto, and A. Nomoto
J. Antibiot. 2019, 72, 125-133.

Local structural changes of the influenza A virus ribonucleoprotein complex by single mutations in the specific residues involved in efficient genome packaging.
N. Takizawa,Y. Ogura, Y. Fujita, T. Noda, H. Shigematsu, T. Hayashi and K. Kurokawa
Virology 2019, 531, 126-140.

Apical trafficking pathways of influenza A virus HA and NA via Rab17- and Rab23-positive compartments.
R. Sato, T. Okura, M. Kawahara, N. Takizawa, F. Momose and Y. Morikawa
Front. Microbiol., 2019, 10, 1857.

A new biomarker candidate for spinal muscular atrophy : Identification of a peripheral blood cell population capable of monitoring the level of survival motor neuron protein.
N. Otsuki, R. Arakawa, K. Kaneko, R. Aoki, M. Arakawa and K. Saito
PLoS One 2018, 13(8), e0201764.

Translation of Hepatitis A virus IRES is upregulated by a hepatic cell-specific factor.
A. Sadahiro, A. Fukao, M. Kosaka, Y. Funakami, N. Takizawa, O. Takeuchi, K.E. Duncan and T. Fujiwara
Front. Geneti., 2018, 9, 307.

Current landscape and future prospects of antiviral drugs derived from microbial products.
N. Takizawa and M. Yamasaki
J. Antibiot. 2018, 71, 45-52.

Anti-influenza virus activity of a salcomine derivative mediated by inhibition of viral RNA synthesis.
N. Takizawa, T. Kimura, T. Watanabe and M. Shibasaki
Arch. Virol. 2018, 163, 1607-1614.

Efficient genome replication of hepatitis B virus using adenovirus vector: a compact pregenomic RNA-expression unit.
M. Suzuki, S. Kondo, M. Yamasaki, N. Matsuda, A. Nomoto, T. Suzuki, I. Saito and Y. Kanegae
Sci. Rep. 2017, 7:41851, doi: 10.1038/srep41851.

Generation of a Genetically Stable High-Fidelity Influenza Vaccine Strain.
T. Naito, K. Mori, H. Ushirogawa, N. Takizawa, E. Nobusawa, T. Odagiri, M. Tashiro, R. L. Ohniwa, K. Nagata, and M. Saito
J. Virol. 2017, 91, e01073-16.

Imaging flow cytometry analysis to identify differences of survival motor neuron protein expression in patients with spinal muscular atrophy.
R. Arakawa, M. Arakawa, K. Kaneko, N. Otsuki, R. Aoki and K. Saito.
Pediatr. Neurol. 2016, 61, 70-75.

Influenza a virus hemagglutinin is required for the assembly of viral components including bundled vRNPs at the lipid raft.
N. Takizawa, F. Momose, Y. Morikawa and A. Nomoto.
Viruses 2016, 8, 249

Short intracellular HIV-1 transcripts as biomarkers of residual immune activation in patients on antiretroviral therapy.
A. Ishizaka, H. Sato, H. Nakamura, M. Koga, T. Kikuchi, N. Hosoya, T.Koibuchi, A. Nomoto, A. Kawana-Tachikawa and T. Mizutani
J. Virol. 2016, 90, 5665-5676.

Transferrin Receptor 1 Facilitates Poliovirus Permeation of Mouse
Brain Capillary Endothelial Cells.
T. Mizutani, A. Ishizaka and C. Nihei.
J. Biol. Chem. 2016, 291, 2829-2836.

The werner protein acts as a coactivator of NF-κB on HIV-1 and IL-8 promoters.
T. Mizutani, A. Ishizaka and Y. Furuichi
J. Biol. Chem. 2015, 290, 18391-18399

A novel evaluation method of survival motor neuron protein as a biomarker of spinal muscular atrophy by imaging flow cytometry.
M. Arakawa, R. Arakawa, S. Tatsumi, R. Aoki, K. Saito and A. Nomoto.
Biochem. Biophys. Res. Commun. 2014, 453, 368-374.

All-atom molecular dynamics calculation study of entire pollovirus empty capsids in solution.
Y. Andoh, N. Yoshii, A. Yamada, K. Fujimoto, H. Kojima, K. Mizutani, A. Nakagawa,
A. Nomoto and S. Okazaki.
J. Chem. Phys. 2014, 141, 165101.

Suppression of hepatitis C virus replication by cyclin-dependent Kinase inhibitors.
T. Munakata, M. Inada, Y. Tokunaga, T. Wakita, M. Kohara and A. Nomoto.
Antivir. Res. 2014, 108, 79-87.

7SK small nuclear ribonucleoprotein complex is recruited to the HIV-1 promoter via short viral transcripts.
T. Mizutani, A. Ishizaka, Y. Suzuki and H. Iba.
FEBS Lett. 2014, 588, 1630-1636.

Structural insights into the recruitment of SMRT by the corepressor SHARP under phosphorylative regulation.
S. Mikami, T. Kanaba, N. Takizawa, A. Kobayashi, R. Maesaki, T. Fujiwara, Y. Ito and M. Mishima.
Structure 2013, 22, 1-12.

The essential role for the RNA triphosphatase Cet1p in nuclear import of the mRNA capping enzyme Cet1p-Ceg1p complex of Saccharomyces cerevisiae.
N. Takizawa, T. Fujiwara, M. Yamasaki, A. Saito, A. Fukao, A. Nomoto and K. Mizumoto.
PLOS ONE 2013, 8, e 78000.

Structure of the second RRM domain of Nrd1, a fission yeast MAPK target RNA binding protein, and implication for its RNA recognition and regulation.
A. Kobayashi, T. Kanaba, R. Satoh, T. Fujiwara, Y. Ito, R. Sugiura and M. Mishima.
Biochem. Biophys. Res. Commun. 2013, 437, 12-17.

Amycolamicin: a novel broad-spectrum antibiotic inhibiting bacterial topoisomerase.
R. Sawa, Y. Takahashi, H. Hashizume, K. Sasaki, Y. Ishizaki, M.Umekita, M. Hatano, H. Abe, T. Watanabe, N. Kinoshita, Y. Homma, C. Hayashi, K. Inoue, S. Ohba, T. Masuda, M. Arakawa, Y. Kobayashi, M. Hamada, M. Igarashi, H. Adachi, Y. Nishimura and Y. Akamatsu.
Chem. Eur. J. 2012, 18, 15772-15781.

HSC90 is required for nascent hepatitis C virus core protein stability in yeast cells.
N. Kubota, Y. Inayoshi, N. Satoh, T. Fukuda, K. Iwai, H. Tomoda, M. Kohara, K. Kataoka, A. Shimamoto, Y. Furuichi, A. Nomoto, A. Naganuma and S. Kuge.
FEBS Lett. 2012, 586, 2318-2325.

Poliovirus trafficking toward central nervous system via human poliovirus receptor-dependent and -independent pathway.
S. Ohka, C. Nihei, M. Yamazaki and A. Nomoto.
Frontiers in Microbiology 2012, 3, 1-5.

RNA 結合タンパク質による翻訳制御
藤原俊伸
細胞工学「神経形の翻訳制御メカニズム」 2012, 31, 646-654.

The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation.
I. Tanida, M. Yamasaki, M. Komatsu and T. Ueno.
Autophagy 2012, 8, 88-97.

Human first-trimester chorionic villi have a myogenic potential.
R. Arakawa, R. Aoki, M. Arakawa and K. Saito.
Cell Tissue Res. 2012, 348, 189-197.

Functional and direct interaction between the RNA binding protein HuD and active Akt1.
T. Fujiwara, A. Fukao, Y. Sasano, H. Matsuzaki, U. Kikkawa, H. Imataka, K. Inoue, S. Endo, N. Sonenberg, C. Thoma and H. Sakamoto.
Nucleic Acids Res. 2012, 40, 1944-1953.

Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF-kappaB RelA/p50 heterodimer.
A. Ishizaka, T. Mizutani, K. Kobayashi, T. Tando, K. Sakurai, T. Fujiwara and H. Iba.
J. Biol. Chem. 2012, 287, 11924-11933.

Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish.
Y. Mishima, A. Fukao, T. Kishimoto, H. Sakamoto, T. Fujiwara and K. Inoue.
Proc. Natl. Acad. Sci. USA 2012, 109, 1104-1109.

ポリオ感染の分子機構から根絶まで
野本明男
感染・炎症・免疫 2011, 41, 42-53.

Small subunit processome、核小体タンパク質フィブリラリン
牛田千里、藤原俊伸
生体の科学「細胞核 - 構造と機能」 2011, 62, 418-421.

発生・分化と翻訳制御－RNA結合蛋白質がつかさどる高次生命現象
深尾亜喜良、藤原俊伸
医学のあゆみ「RNA医学・医療」 2011, 238, 418-425.

Development of recombinant hepatitis C virus with NS5A from strains of genotypes 1 and 2.
Y. Okamoto, T. Masaki, A. Murayama, T. Munakata, A. Nomoto, S. Nakamoto, O. Yokosuka, H. Watanabe, T. Wakita, and T. Kato.
Biochem. Biophys. Res. Commun. 2011, 410, 04-409.

Mechanisms of translational regulation by a human eIF5-mimic protein.
C. R. Singh, R. Watanabe, D. Zhou, M. D. Jennings, A. Fukao, B. Lee, Y. Ikeda, J. A. Chiorini, S. G. Campbell, M. P. Ashe, T. Fujiwara, R. C. Wek, G. D. Pavitt and K. Asano.
Nucleic Acids Res. 2011, 39, 8314-8328.

Dynamic profiling of mRNA turnover reveals gene-specific and system-wide regulation of mRNA decay.
S. E. Munchel, R. K. Shultzaberger, N. Takizawa and K. Weis.
Mol. Biol. Cell 2011, 22, 2787-2795.

Crucial role of the influenza virus NS2 (NEP) C-terminal domain in M1 binding and nuclear export of vRNP.
T. Shimizu, N. Takizawa, K. Watanabe, K. Nagata and N. Kobayashi.
FEBS Lett. 2011, 585, 41-46.

Sorting of influenza A virus RNA genome segments after nuclear export.
N. Takizawa, M. Kumakura, K. Takeuchi, N. Kobayashi and K. Nagata.
Virology 2010, 401, 248-256.

Poliomyelitis.
S. Koike and A. Nomoto.
The Picornaviruses 2010, 339-351.

2A protease is not a prerequisite for poliovirus replication.
H. Igarashi, Y. Yoshino, M. Miyazawa, H. Horie, S. Ohka and A. Nomoto.
J. Virol. 2010, 84, 5947-5957.

Involvement of vesicular trafficking system in membrane targeting of the progeny influenza virus genome.
S. Jo, A. Kawaguchi, N. Takizawa, Y. Morikawa, F. Momose and K. Nagata.
Microbes Infect. 2010, 12, 1079-1084.

Distribution of Kakugo virus and its effects on the gene expression profile in the brain of the worker honeybee Apis mellifera L.
T. Fujiyuki, E. Matsuzaka, T. Nakaoka, H. Takeuchi, A. Wakamoto, S. Ohka, K. Sekimizu, A. Nomoto and T. Kubo.
J. Virol. 2009, 83, 11560-11568.

Receptor-dependent and -independent axonal retrograde transport of poliovirus in motor neurons.
S. Ohka, M. Sakai, S. Bohnert, H. Igarashi, K. Deinhardt, G. Schiavo and A. Nomoto.
J. Virol. 2009, 83, 4995-5004.

Induction of immune responses to a human immunodeficiency virus type 1 epitope by novel chimeric influenza viruses.
N. Takizawa, M. Morita, K. Adachi, K. Watanabe and N. Kobayashi.
Drug Discov. Ther. 2009, 3, 252-259.

Comparative aspects on the role of polypyrimidine tract-binding protein in internal initiation of hepatitis C virus and picornavirus RNAs.
T. Nishimura, M. Saito, T. Takano, A. Nomoto, M. Kohara and K. Tsukiyama-Kohara.
Comp. Immunol. Microbiol. Infect. Dis. 2008, 31, 435-448.

Efficient propagation of betanodavirus in a murine astrocytoma cell line.
N. Takizawa, K. Adachi, T. Ichinose and N. Kobayashi.
Virus Res. 2008, 136, 206-210.

Establishment of reverse genetics system of betanodavirus for the efficient recovery of infectious particles.
N. Takizawa, K. Adachi and N. Kobayashi.
J. Virol. Methods 2008, 151, 271-276.

Hsc70 regulates the nuclear export but not the import of influenza viral RNP: A possible target for the development of anti-influenza virus drugs.
K. Watanabe, N. Takizawa, S. Noda, F. Tsukahara, Y. Maru and N. Kobayashi.
Drug Discov. Ther. 2008, 2, 77-84.

※前所属での業績も含む
*The papers published in previous lab are included.