化学系研究部創薬化学研究部

研究業績

Synthesis and antiviral activity of formycin derivatives with anti-influenza virus activity.
H. Takada, N. Takizawa, S. Shibasaki, H. Asaba, M. Igarashi, M. Shibasaki and Y. Takahashi
Bioorganic & Medicinal Chemistry, 2022, 57, https://doi.org/10.1016/j.bmc.2022.116613

Anti-influenza virus activity of methylthio-formycin distinct from that of T-705.
N. Takizawa, H. Takada, M. Umekita, M. Igarashi and Y. Takahashi
Front Microbiol. 2022, 13, 802671. doi: 10.3389/fmicb. 2022.802671

Micromonosporamide a with glutamine-dependent cytotoxicity from micromonospora sp. MM609M-173N6: isolation, stereochemical determination, and synthesis.
T. Takeuchi, M. Hatano, H. Muramatsu, Y. Kubota, R. Sawa and M. Igarashi
Org. Lett., 2021, 23, 7981-7985

Pd-catalyzed methylene γ-C(sp3)-H alkenylation of N picolinoylcycloalkylamines with alkenyl iodides promoted by 2-tert-butyl-1,4 benzoquinone.
A. Seki and Y. Takahashi
Tetrahedron Lett., 2021, 74.

Synthesis and biological activity of analogs of CPZEN-45, a novel antituberculosis drug.
Y. Ishizaki, Y. Takahashi, T. Kimura, M. Inoue, C. Hayashi and M. Igarashi.
J. Antibiot., 2019, 72, 970-980.

天然物からの次世代新規抗生物質の探索
五十嵐雅之、高橋良昭
日本化学療法学会雑誌　2019, 67(3), 308-323

Systematic and stereoselective total synthesis of mannosylerythritol lipids and evaluation of their antibacterial activity.
J. Nashida, N. Nishi, Y. Takahashi, C. Hayashi, M. Igarashi, D. Takahashi and K. Toshima
J. Org. Chem. 2018, 83, 7281-7289

Trans-selective γ-arylation of macrocyclic N-picolinoylcycloalkylamines through palladium-catalyzed methylene sp3 carbon-hydrogen bond activation.
A. Seki
Tetrahedron Lett. 2017, 58, 4232-4235

Synthesis and antibacterial activity of 4” or 6”-alkanoylamino derivatives of aebekacin.
K. Sasaki, Y. Kobayashi, T. Kurihara, Y. Yamashita, Y. Takahashi, T. Miyake and Y. Akamatsu
J. Antibiot. 2015, 68, 741-747

Synthesis and antibacterial activity of tripropeptin C derivatives containing the pyrimidine ring system.
S. Hirosawa, Y. Takahashi, A. Murotani, H. Hashizume, T. Miyake and Y. Akamatsu
Heterocycles 2015, 91, 2143-2151

Synthesis and antibacterial activity of 1-N-[(S)-ω-amino-2-hydroxyalkyl] derivatives of dibekacin,
5-deoxydibekacin, 3’-deoxykanamycin A and gentamicin B.
E. Umemura, Y. Sakamoto, Y. Takahashi and T. Miyake
J. Antibiot. 2015, 68, 421-423

Synthesis of 17-membered azalides from a 16-membered macrolide utilizing amide-selective silane reduction.
A. Seki, T. Mori, K. Sasaki, Y. Takahashi, T. Miyake and Y. Akamatsu
Med. Chem. Commun. 2015, 6, 581-585

Synthesis and antibacterial activity of tripropeptin C derivatives modified at the carboxyl groups.
S. Hirosawa, Y. Takahashi, H. Hashizume, T. Miyake and Y. Akamatsu
J. Antibiot. 2014, 67, 265-268

Synthesis of cis-3-arylated cycloalkylamines through palladium-catalyzed methylene sp³ carbon-hydrogen bond activation.
A. Seki, Y. Takahashi, and T. Miyake
Tetrahedron Lett. 2014, 55, 2838-2841

Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazaymicin derivative CPZEN-45.
Y. Ishizaki, C. Hayashi, K. Inoue, M. Igarashi, Y. Takahashi, V. Pujari, D. C. Crick, P. J. Brennan and A. Nomoto
J. Biol. Chem. 2013, 288, 30309-30319

Novel semisynthetic antibiotics from caprazamycins A-G: caprazene derivatives
and their antibacterial activity.
Y. Takahashi, M. Igarashi, T. Miyake, H. Soutome, K. Ishikawa, Y. Komatsuki,
Y. Koyama, N. Nakagawa, S. Hattori, K. Inoue, N. Doi and Y. Akamatsu
J. Antibiot. 2013, 66, 171-178

Amycolamicin: a novel broad-spectrum antibiotic inhibiting bacterial topoisomerase.
R. Sawa, Y. Takahashi, H. Hashizume, K. Sasaki, Y. Ishizaki, M. Umekita, M. Hatano,
H. Abe, T. Watanabe, N. Kinoshita, Y. Homma, C. Hayashi, K. Inoue, S. Ohba,
T. Masuda, M. Arakawa, Y. Kobayashi, M. Hamada, M. Igarashi, H. Adachi,
Y. Nishimura and Y. Akamatsu
Chem. Eur. J. 2012, 18, 15772-15781

新しい抗結核薬の開発状況
五十嵐雅之、高橋良昭
日本臨牀：結核とその類縁疾患 2011, 69, 1482-1488