Producing organism:

Streptomyces sp. MJ858-NF3


Farnesyltransferase inhibitor

Clinical use:


Class no:

3 Reference(s)

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Title Author Journal Year Volume Page
Synthesis and stereochemistry of valinoctin A, a novel farnesyltransferase inhibitor from Streptomyces sp. Y. Muraoka; R. Sekizawa; H. Nakamura; M. Tsuda; K. Umezawa; T. Takeuchi Peptide Chemistry1995Protein Research Foundation 1996 (Ed. N.Nishi) 1996 149-152
Isolation and synthesis of novel farnesyl protein transferase inhibitors, valinoctins A and B, from Streptomyces strain MJ858-NF3. R. Sekizawa; H. Iinuma; Y. Muraoka; H. Naganawa; N. Kinoshita; H. Nakamura; M. Hamada; T. Takeuchi; K. Umezawa J. Natural Product 1996 59 232-236
Stereospecific synthesis of a novel farnesyl protein transferase inhibitor, valinoctin A and its analogues. M. Tsuda; Y. Muraoka; T. Takeuchi J. Antibiotics 1996 49 1031-1035