Compounds

Thiazinotrienomycin

Thiazinotrienomycin_1

Producing organism:

Streptomyces sp. MJ672-m3

Activity:

Antitumor

Clinical use:

-

Class no:

2 Reference(s)

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Title Author Journal Year Volume Page
Thiazinotrienomycins, new ansamycin group antibiotics. N. Hosokawa; H. Naganawa; H. Iinuma; M. Hamada; T. Takeuchi; T. Kanbe, and M. Hori J. Antibiot. 1995 48 471-478
(+)-Thiazinotrienomycin E: relative and absolute stereochemistry. A. B. Smith, III; J. Barbosa; N. Hosokawa; H. Naganawa, and T. Takeuchi Tetrahedron Letters 1998 39 2891-2894
Effect of thiazinotrienomycin B, an ansamycin antibiotics, on the function of EGFR in human stomach tumor cells. N. Hosokawa, S. Yamamoto, Y. Uehara, M. Hori, and K. S. Tsuchiya J. Antibiot. 1999 52 485-490
Anticancer and some biological activities of thiazinotrienomycin B. N. Hosokawa, H. iinuma, T. Takeuchi, S. Sato, and T. Yamori J. Antibiot. 2000 53 306-308
New triene-ansamycins, thiazinotrienomycins F and G and a diene-ansamycin, Benzoxazomycin. N. Hosokawa, H. Naganawa, M. Hamada, H. Iinuma, T. Takeuchi, K. S. Tsuchiya, and M. Hori J. Antibiot. 2000 53 886-894
Total synthesis of (+)-thiazinotrienomycin E. A. B. Smith III, and W. Zehong Organic Letters 1999 1 1491-1494
Total synthesis of ansamycin antibiotic (+)-thiazinotrienomycin E. A. B. Smith III, and W. Zehong J. O. C. (The compound and its producing bacterial strain covered this Journal.) 2000 65 3738-3753
New ansamycin derivatives generated by simultaneous mutasynthesis (Benzoxazomycin) Y. N. Song, R. H. Jiao, W. J. Zhang, G. Y. Zhao, H. Dou, R. Jiang, A. H. Zhang, Y. Y. Hou, S. F. Bi, H. M. Ge, and R. X. Tan Organic Letters 2015 17 556-559
Narural occurrence, bioactivity, and biosynthesis of triene-ansamycins X. Yang, W. Wu, H. Li, M. Zhang, Z, Chu, X. Wang, and P. Sun European Journal of Medicinal Chemistry 2022 https:/doi.org/10.1016/j.emech.2022.114815