Biology DivisionLaboratory of Microbial Carcinogenesis

Research Outline

The research purpose of our laboratory is to elucidate the elementary processes of vital reactions by making full use of techniques based on molecular biology, biochemistry (enzymology), and cell biology. We promote original drug discovery research based on the results obtained in our studies. Furthermore, we provide technical support for the drug discovery research of IMC by developing experimental systems that can verify the mode of action of novel compounds. In particular, we are elucidating the elementary processes underlying the systems of viral and intractable diseases and have developed new agents against these diseases.

Members

  • PHOTOGRAPH

    Laboratory Head Masanori Hatakeyama »Biography

Number of Members 9

Themes

  1. H. pylori infection and gastric cancinogenesis
  2. Research involving the influenza virus
  3. Research on the chronic infection of Hepatitis B virus (HBV).
  4. New therapeutic strategy: Targeting neuromuscular junction (NMJ) to Neuromuscular diseases

Theme outlines

1. H. pylori infection and gastric cancinogenesis

Helicobacter pylori (H. pylori), a spinal-shaped bacterium that colonizes the human gastric mucosa, is estimated to inhabit at least half of the world’s human population. Since its first report in 1982 by Marshall and Warren, H. pylori has been recognized as the etiological agent of gastric diseases such as chronic atrophic gastritis and peptic ulcers. However, some of the H. pylori-infected individuals develop gastric diseases because many of those have no diseases. We have demonstrated that infection with cagA-positive Helicobacter pylori is causatively associated with the development of gastric carcinoma. Our laboratory is focusing on the oncogenic mechanism of CagA in terms of the mechanism of carcinogenesis initiated by H. pylori infection.

Perturbation of intracellular signaling by H. pylori CagA

2. Research involving the influenza virus

Elucidating molecular mechanism of each process
Screening of anti-influenza virus compounds from natural products

3. Research on the infection of Hepatitis B virus (HBV).

4. New therapeutic strategy: Targeting neuromuscular junction (NMJ) to Neuromuscular diseases

Screening of natural products for the discovery of drugs relating to Neuromuscular diseases.