Garsubellin A

Inducer of choline acetyltransferase:
a promising agent for Alzheimer disease


Hyperforin

mild antidepressant element

Abstract
-Synthetic Studies-

Usuda, H.; Kanai, M.; Shibasaki, M. Org. Lett. 2002, 4, 859.
Usuda, H.; Kanai, M.; Shibasaki, M. Tetrahedron Lett. 2002, 43, 3621.

-Synthetic Approach: Catalytic Asymmetric Diels-Alder Reaction-



Usuda, H.; Kuramochi, A.; Kanai, M.; Shibasaki, M. Org. Lett. 2004, 6, 4387.

-Achieved Total Synthesis-



Kuramochi, A.; Usuda, H.; Yamatsugu, K.; Kanai, M.; Shibasaki, M. J. Am. Chem. Soc. 2005, 127, 14200 - 14201.

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