Linked-BINOL

> Epoxide Opening Reaction(GaLi-linked-BINOL)
> Micheal Reactions (La-linked-BINOL)
> Direct Aldol Reaction (Et2Zn-linked-BINOL)
> Micheal Reaction (Et2Zn-linked-BINOL)
> Direct Mannich-Type Reaction (Et2Zn-linked-BINOL)
> Direct Mannich-Type Reaction (In-linked-BINOL)
> Direct Mannich-Type Reaction (Y-linked-BINOL)

Review:
Adv. Synth. Catal. 2002, 344, 3-15.
Chem. Soc. Rev. 2006, 47, 269-279.
J. Organomet. Chem. 2006, 691, 2089-2100.
Epoxide Opening Reaction (GaLi-linked-BINOL)



Matsunaga, S.; Das, J.; Roels, J.; Vogl, E. M.; Yamamoto, N.; Iida, T.; Yamaguchi, K.; Shibasaki, M.
J. Am. Chem. Soc. 2000, 122, 2252-2260.
Micheal Reactions (La-linked-BINOL)
Malonate



Kim, Y. S. ; Matsunaga, S.; Das, J.; Sekine, A.; Ohshima, T.; Shibasaki, M. J. Am. Chem. Soc. 2000, 122, 6506-6507.
Takita, R.; Ohshima, T.; Shibasaki, M. Tetrahedron Lett. 2002, 43, 4661-4665.

β-Ketoester

Majima, K.; Takita, R.; Okada, A.; Ohshima, T.; Shibasaki, M. J. Am. Chem. Soc. 2003, 125, 15837-15845.
Majima, K.; Tosaki, S.-y; Ohshima, T.; Shibasaki, M.Tetrahedron Lett. 2005, 46, 5377-5381.

Direct Aldol Reaction (Et2Zn-linked-BINOL)



Kumagai, N.; Matsunaga, S.; Yoshikawa, N.; Ohshima, T.; Shibasaki, M. Org. Lett. 2001, 3, 1539-1542.
Kumagai, N.; Matsunaga, S.; Kinoshita, T.; Harada, S.; Okada, S.; Sakamoto, S.; Yamaguchi, K.; Shibasaki, M.
J. Am. Chem. Soc. 2003, 125, 2169-2178.
Micheal Reaction (Et2Zn-linked-BINOL)



Kumagai, N.; Matsunaga, S.;Shibasaki, M. Org. Lett. 2001, 3, 4251-4254.
Harada, S.; Kumagai, N.; Kinoshita, T.; Matsunaga, S.; Shibasaki, M. J. Am. Chem. Soc. 2003, 125, 2582-2590.
Direct Mannich-Type Reaction (Et2Zn-linked-BINOL)



Matsunaga, S.; Kumagai, N.; Harada, S.; Shibasaki, M. J. Am. Chem. Soc. 2003, 125, 4712-4713.
Matsunaga, S.; Yoshida, T.; Morimoto, H.; Kumagai, N.; Shibasaki, M. J. Am. Chem. Soc. 2004, 126, 8777-8785.
Yamaguchi, A.; Matsunaga, S.; Shibasaki, M. Tetrahedron Lett. 2006, 47, 3985.
Direct Mannich-Type Reaction (In-linked-BINOL)



Harada, S.; Handa, S.; Matsunaga S.; Shibasaki, M. Angew. Chem. Int. Ed. 2005, 44, 4365-4368.
Direct Mannich-Type Reaction (Y-linked-BINOL)



Sugita, M.; Yamaguchi, A.; Yamagiwa, N.; Handa, S.; Matsunaga, S.; Shibasaki, M. Org. Lett. 2005, 7, 5339.

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