REMB

> Nitro-Aldol Reaction
> Direct Aldol Reactions
> Asymmetric Protonation
> Nitro-Mannich Type Reaction
> Cyanation
> Sequencial Asymmetric Cyanation-Nitroaldol Reaction
> 1,4-Addition of Methoxylamine
> Direct Aldol-Tischenko reaction

Review :
Chem. Rev. 2002, 102, 2187-2210.
Nitro-Aldol Reaction



Sasai, H.; Suzuki, T.; Arai, S.; Arai, T.; Shibasaki, M. J. Am. Chem. Soc. 1992, 114, 4418.
Shibasaki, M.; Sasai, H.; Arai, T. Angew. Chem., Int. Ed. Engl. 1997, 36, 1236.
Tertiary Nitroaldol Resolution


Tosaki, S.-y.; Hara, K.; Gnanadesikan, V.; Morimoto, H.; Harada, S.; Sugita, M.; Yamagiwa, N.; Matsunaga, S.; Shibasaki, M. J. Am. Chem. Soc. 2006, 128, 11776.
Doubly Diastereoselective Nitroaldol Reactions


Sohtome, Y.; Kato, Y.; Handa, S.; Aoyama, N.; Nagawa, K.; Matsunaga, S.; Shibasaki, M. Org. Lett. 2008, 10, 2231.
Direct Aldol Reactions
UNDER CONSTRUCTION


Yamada,Y. M. A.; Yoshikawa, N.; Sasai, H.; Shibasaki, M. Angew. Chem. Int. Ed., Engl. 1997, 36, 1871-1873.
Yoshikawa, N.; Yamada, Y. M. A.; Das, J.; Sasai, H.; Shibasaki, M. J. Am. Chem. Soc. 1999, 121, 3089-3103.
α-hydroxy ketones



Yoshikawa, N.; Kumagai, N.; Matsunaga, S.; Moll, G.; Ohshima, T.; Suzuki, T.; Shibasaki, M. J. Am. Chem. Soc. 2001, 123, 2466-2467.
Glycinate Schiff bases



Yoshikawa, N.; Shibasaki, M. Tetrahedron 2002, 58, 8289-8298.
Asymemtric Protonation



Emori, E.; Arai, T.; Sasai, H.; Shibasaki, M. J. Am. Chem. Soc. 1998, 120, 4043-4044.
Nitro-Mannich Type Reaction



Yamada, K.-i.; Harwood, S. J.; Groeger, H.; Shibasaki, M. Angew. Chem., Int. Ed. 1999, 38, 3504-3506.
Yamada, K.-i.; Moll, G.; Shibasaki, M. Synlett 2001, 980-982.
Cyanation



Tian, J.; Yamagiwa, N.; Matsunaga, S.; Shibasaki, M. Angew. Chem., Int. Ed. 2002, 41, 3636-3638.
Tian, J.; Yamagiwa, N.; Matsunaga, S.; Shibasaki, M. Org. Lett. 2003, 5, 3021-3024.
Abiko, Y.; Yamagiwa, N.; Sugita, M.; Tian, J.; Matsunaga, S.; Shibasaki, M. Synlett 2004, 2434-2436.
Yamagiwa, N.; Tian,J.; Matsunaga, S.; Shibasaki, M. J. Am. Chem. Soc. 2005,127, 3413-3422.
Sequencial Asymmetric Cyanation-Nitroaldol Reaction

Presentation Figure (by Dr. Yamagiwa)

Tian, J.; Yamagiwa, N.; Matsunaga, S.; Shibasaki, M. Angew. Chem. Int. Ed. 2002, 41, 3636-3638.
1,4-Addition of Methoxylamine



Yamagiwa, N.; Matsunaga, S.; Shibasaki, M. J. Am. Chem. Soc. 2003, 125, 16178-16179.
Yamagiwa, N.; Matsunaga, S.; Shibasaki, M. Angew. Chem. Int. Ed. 2004, 43, 4493-4497.
Yamagiwa, N; Qin, H.; Matsunaga, S.; Shibasaki, M. J. Am. Chem. Soc. 2005, 127, 13419-13427.
Direct Aldol-Tishchenko Reaction




Gnanadesikan, V.; Horiuchi, Y.; Ohshima, T.; Shibasaki, M. J. Am. Chem. Soc. 2004, 126, 7782-7783.
Horiuchi, Y.; Gnanadesikan, V.; Ohshima, T.; Masu, H.; Katagiri, K.; Sei, Y.; Yamaguchi, K.; Shibasaki, M.
Chem. Eur. J. 2005, 11, 5195-5204.
Cyclopropanation of Enone




Kakei, H.; Sone, T.; Shotome, Y.; Matsunaga, S.; Shibasaki, M. J. Am. Chem. Soc. 2007, 129, 13410-13411.

(Editor: Y. Yanagida, Y. Saga and elders)

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