創薬化学研究部

研究業績

Trans-selective γ-arylation of macrocyclic N-picolinoylcycloalkylamines through palladium-catalyzed methylene sp3 carbon-hydrogen bond activation.
A. Seki
Tetrahedron Lett. 2017 in press doi: 10.1016/j.tetlet.2017.09.055
Synthesis and antibacterial activity of 4” or 6”-alkanoylamino derivatives of aebekacin.
K. Sasaki, Y. Kobayashi, T. Kurihara, Y. Yamashita, Y. Takahashi, T. Miyake and Y. Akamatsu.
J Antibiot. 2015, 68, 741-747
Synthesis and antibacterial activity of tripropeptin C derivatives containing the pyrimidine ring system.
S. Hirosawa, Y. Takahashi, A. Murotani, H. Hashizume, T. Miyake and Y. Akamatsu.
Heterocycles. 2015, 91, 2143-2151.
Synthesis and antibacterial activity of 1-N-[(S)-ω-amino-2-hydroxyalkyl] derivatives of dibekacin,
5-deoxydibekacin, 3’-deoxykanamycin A and gentamicin B.
E. Umemura, Y. Sakamoto, Y. Takahashi and T. Miyake.
J Antibiot.2015, 68, 421-423
Synthesis of 17-membered azalides from a 16-membered macrolide utilizing amide-selective silane reduction.
A. Seki, T. Mori, K. Sasaki, Y. Takahashi, T. Miyake and Y. Akamatsu.
Med. Chem. Commun. Med. Chem. Commun.  2015, 6, 581-585
Synthesis and antibacterial activity of tripropeptin C derivatives modified at the carboxyl groups.
S. Hirosawa, Y. Takahashi, H. Hashizume, T. Miyake and Y. Akamatsu.
J. Antibiot.  2014,  67,  265-268
Synthesis of cis-3-arylated cycloalkylamines through palladium-catalyzed methylene sp³ carbon-hydrogen bond activation.
A. Seki, Y. Takahashi, and T. Miyake.
Tetrahedron Letters.  2014,  55,  2838-2841
Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazaymicin derivative CPZEN-45.
Y. Ishizaki, C. Hayashi, K. Inoue, M. Igarashi, Y. Takahashi, V. Pujari, D. C. Crick, P. J. Brennan and A. Nomoto.
J. Biol. Chem.  2013,  288,  30309-30319.
Novel semisynthetic antibiotics from caprazamycins A-G: caprazene derivatives
and their antibacterial activity.
Y. Takahashi, M. Igarashi, T. Miyake, H. Soutome, K. Ishikawa, Y. Komatsuki,
Y. Koyama, N. Nakagawa, S. Hattori,K. Inoue, N. Doi and Y. Akamatsu.
J. Antibiot.  2013,  66,  171-178.
Amycolamicin: a novel broad-spectrum antibiotic inhibiting bacterial topoisomerase.
R. Sawa, Y. Takahashi, H. Hashizume, K. Sasaki, Y. Ishizaki, M.Umekita, M. Hatano,
H. Abe, T. Watanabe, N. Kinoshita, Y. Homma, C. Hayashi, K. Inoue, S. Ohba,
T. Masuda,  M. Arakawa, Y. Kobayashi, M. Hamada, M. Igarashi, H. Adachi,
Y. Nishimura and Y. Akamatsu.
Chem. Eur. J.  2012,  18,  15772-15781.
新しい抗結核薬の開発状況
五十嵐雅之、高橋良昭
日本臨牀:結核とその類縁疾患 2011, 69, 1482-1488.